Relationship between molecular markers and treatment response in a retrospective cohort of Indian patients with primary carcinoma of the larynx

Sahoo, Rashmita; Chittibabu, V.; Patil, Gururaj B.; Rao, Shyam; Thakur, S.; Dhondalay, Gopal Krishna; Kulkarni, Anant; Banerjee, Anirban; Ajaikumar, B.S.; Korlimarla, Aruna; Nargund, Ashwini; Niti, R. N.; Gopinath, K. S.; Prabhudesai, Shilpa; Raghavendra, R. M.

doi:10.1016/j.oraloncology.2009.07.013

Cited by 6 publications

(5 citation statements)

References 45 publications

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“…In our study, we also did not observe any correlation between p53 expression and response to radiotherapy. Studies done to assess the role of p53 status in predicting response to therapy in laryngeal cancers have demonstrated an association of p53 mutations with improved response to treatment and outcome . Previous studies done on pretreatment biopsies have either shown a correlation between p53 and treatment response or absence of any correlation .…”

Section: Discussionmentioning

confidence: 99%

Bcl‐xL protein: Predictor of complete tumor response in patients with oral cancer treated with curative radiotherapy

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Bcl‐xL protein: Predictor of complete tumor response in patients with oral cancer treated with curative radiotherapy

et al. 2012

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“…Similarly, other studies have shown that overexpression of mutated P53 is frequently detected in a significant proportion of LSCC tissues (20,21). Another study group investigated the potential role of P53 and B-cell lymphoma 2 (BCL2) (gene locus: 18q21.33), an anti-apoptotic factor suppressing and blocking apoptotic signal transduction, as potential reliable molecular markers for patients with LSCC (22). Based on assays of IHC, polymerase chain reaction, DNA ploidy and Sphase fractions, they concluded that aberrant P53 expression due to mutation should be used as a marker for predicting treatment response rates in patients with LSCC.…”

Section: Overexpression Of the Two Markers And Digital Image Analysis...mentioning

confidence: 96%

P53/MDM2 Co-Expression in Laryngeal Squamous Cell Carcinoma Based on Digital Image Analysis

et al. 2019

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Background: P53 is a key regulator of genomic stability and function, acting as a tumor suppressor protein. Our aim was to correlate P53 expression with murine double minute 2 (MDM2), a proto-oncogene that interacts with P53 and forms an auto-regulatory pathway, in laryngeal squamous cell carcinoma (LSCC). Materials and Methods: A total of 50 LSCC cases were included in the study. Immunohistochemistry was applied by using antibodies to P53 and MDM2 in the corresponding tissue sections. Protein expression levels for both molecules were measured by implementing a digital image analysis assay (immunostaining intensity levels, densitometric evaluation). Results: Overexpression of P53 protein was observed in 16/50 (32%) LSCC cases, while 22/50 (44%) cases strongly expressed MDM2 protein. Interestingly, in 13/50 (26%) cases, combined overexpression of P53/MDM2 was detected. Overall P53 was strongly positively correlated with MDM2 expression (p=0.001). Both P53 and MDM2 overexpression were significantly correlated with advanced stage of LSCC (p=0.032 and p=0.001, respectively). Additionally, MDM2 was found to be associated with poorer survival of patients (p=0.046). Conclusion: Aberrant co-expression of P53 and MDM2 is associated with advanced stage in LSCC. Furthermore, MDM2 overexpression is a frequent and critical genetic event in LSCC and seems to negatively affect survival.

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“…The tumor suppressor p53 and the anti-apoptotic protein B cell lymphoma-2 (Bcl-2) are hypothesized to play a key role in carcinogenesis, and upregulated expression of these proteins has been observed in other types of HNSCC ( 15 ). TP53 is a critical tumor suppressor that responds to various stress signals by regulating an anti-proliferative transcriptional program, including transient cell cycle arrest, cellular senescence and apoptosis ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Epstein‑Barr virus infection mediated TP53 and Bcl‑2 expression in nasopharyngeal carcinoma pathogenesis

et al. 2021

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Epstein Barr virus (EBV) stimulates neoplastic transformation of nasopharyngeal epithelial cells through various molecular mechanisms, predominantly affecting inactivation of tumor-suppressor genes and activation of oncogenes. EBV infection is a major risk factor for nasopharyngeal carcinoma (NPC), yet its role in the carcinogenesis is not clear. EBV infection alters the expression of antiapoptotic proteins and tumor suppressor proteins. Therefore, this study investigated the correlation between EBV infection status with B cell lymphoma-2 (Bcl-2) and TP53 protein expression amongst laryngeal and nasopharyngeal cancer cases. This study was performed using 22 nasopharyngeal and 11 laryngeal cancer cases. EBV infection status, TP53 and Bcl-2 protein expression was studied using immunohistochemistry. The majority of the laryngeal cancer cases exhibited a poor prognosis and presented low Bcl-2 expression. A total of 22.7% cases were infected with EBV in the NPC cases. Upregulated TP53 expression was associated with EBV infection in the NPC cohort, and EBV infection was correlated with TP53 upregulation in the patients with NPC, suggesting mutual regulation between TP53 and EBV.

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Relationship between molecular markers and treatment response in a retrospective cohort of Indian patients with primary carcinoma of the larynx

Cited by 6 publications

References 45 publications

Bcl‐xL protein: Predictor of complete tumor response in patients with oral cancer treated with curative radiotherapy

Bcl‐xL protein: Predictor of complete tumor response in patients with oral cancer treated with curative radiotherapy

P53/MDM2 Co-Expression in Laryngeal Squamous Cell Carcinoma Based on Digital Image Analysis

Epstein‑Barr virus infection mediated TP53 and Bcl‑2 expression in nasopharyngeal carcinoma pathogenesis

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