Relationship between metabolic syndrome and diagnoses of periodontal diseases among participants in a large Taiwanese cohort

Tu, Yu–Kang; D’Aiuto, Francesco; Lin, Hung‐Ju; Chen, Yi-Wen; Chien, Kuo–Liong

doi:10.1111/jcpe.12157

Cited by 43 publications

(51 citation statements)

References 22 publications

(24 reference statements)

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“…However, DM patients had high levels of TRG, above normal values (>150 mg/dL), and were positively correlated with two important periodontal parameters, GR and CAL. Our results are in agreement with Tu et al 24 who evaluated associations between lipid parameters and periodontitis and found a positive correlation for TRG and C-reactive protein (CRP). Controversially, Sora et al 25 evaluated the relationship of metabolic syndrome (five cardiovascular risk factors: abdominal obesity, hypertension, reduced HDL, elevated TRG and elevated…”

Section: Immunological Analysissupporting

confidence: 83%

Periodontopathogens, Candida spp. and immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis

Camargo¹,

Silva²,

Miranda³

et al. 2017

Braz. J. Oral Sci.

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This study aimed to evaluate clinical, microbiological and immunological parameters in type 2 diabetes mellitus (DM) in comparison with normoglycemic patients (NDM). Glycemic and lipid profiles and periodontal clinical status were determined for thirty-three patients (17 DM and 16 NDM). The presence of periodontopathogens and species of Candida in subgingival sites were determined by polymerase chain reaction and immunological parameters by ELISA assays. All glycemic and clinical parameters evaluated were higher in the DM group, with statistical difference for fasting glucose, glycated-hemoglobin, and periodontal parameters. Lipid profile (except triglycerides), levels of TNF-α and myeloperoxidase and the prevalence of the tested microorganisms were similar between the groups, except for Candida albicans and Candida glabrata, which was higher in the DM group. In conclusion, although microbiological and immunological parameters were similar in the DM and NDM groups, periodontitis and the levels of some species of Candida were more severe in DM patients.

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Section: Immunological Analysissupporting

confidence: 83%

Periodontopathogens, Candida spp. and immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis

Camargo¹,

Silva²,

Miranda³

et al. 2017

Braz. J. Oral Sci.

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“…31,32,44 Other variations include the number of teeth and sites on teeth examined. 25-32,39,44-47 A few studies used self-evaluation of the periodontal condition 48,49 or tooth mobility and a non-specified index of gingival inflammation 50 (Tables 1 and 2). …”

Section: Critical Factors Involved In Assessing the Association Bementioning

confidence: 99%

“…67 However, some of these studies identified the exposure (explanatory or independent) and outcome variables 25,30,32,34,36,44-46,48,51 with directionality (Tables 1 and 2). For other studies which did not identify the exposure and outcome variables, 31,33,35,37,38,40,41,44,47,50 we interpreted directionality based on the authors’ description. There are only a few case control studies 30,32,36 and longitudinal studies are available.…”

Section: Critical Factors Involved In Assessing the Association Bementioning

confidence: 99%

Periodontal disease and metabolic syndrome: A qualitative critical review of their association

Watanabe

Cho

2014

Archives of Oral Biology

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Background Metabolic syndrome (MetS) is a conglomerate of several physical conditions/diseases that, as a group, increases the risk of mortality resulting from development of T2DM and cardiovascular diseases (CVD). These conditions/diseases include glucose intolerance/insulin resistance, hypertension, obesity, and dyslipidemia. The results from epidemiological studies suggest that there is an association between metabolic syndrome (MetS) and periodontitis, it is therefore important to understand the current status of the association and a possible contribution of periodontitis to MetS. Objective This review will qualitatively analyze published papers on the association of MetS and periodontitis/periodontal disease to clarify the current status of the association and suggest future directions for studies which may unravel the causal relationship between them. Results Of 309 papers related to MetS and periodontitis, 26 are original research papers that investigated the relationship/association between periodontal disease and MetS. Criteria used to assess periodontitis and MetS as well as overall study designs and patient recruitment criteria varied greatly among these studies. Conclusion All these studies demonstrated a positive association between periodontal disease and MetS. However, due to the heterogeneity of criteria to assess periodontitis and MetS and also paucity of longitudinal studies, it is difficult to determine the relative contribution of periodontitis to MetS. Age and the number of positive components of MetS appear to strengthen the relationship, however, incidence of each disease entity increases with ageing. Thus, mechanistic studies are also necessary to unravel the inter-relationship between periodontitis and MetS. In this regard, a use of animal models will be helpful as they are more uniform in regards to genetic background and have minimum confounding factors. Finally, development of accurate, quantitative assessment of gingival inflammation are necessary in order to determine the influence of periodontal disease on the development of MetS and its components.

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“…Also, in patients with diabetes mellitus and periodontal disease, there may be an increase in some inflammatory factors such as IL6 and TNFα that results in dyslipidemia and hypertriglyceridemia (44,45). In one cohort study evaluating the relationship between metabolic syndrome and periodontal disease, Tu et al showed that patients with periodontal disease have higher levels of blood triglycerides (14). In a study conducted by Mointaghavi et al, no significant decrease was observed in serum TG in diabetic patients after periodontal treatment (34).…”

Section: Discussionmentioning

confidence: 99%

“…These inflammatory factors may adversely alter blood glucose and lipid metabolism (13). In a large cohort study in Taiwan (from 2003 to 2009), a significant association was observed between metabolic syndrome and diagnosis of periodontal disease (14). According to the findings of some studies, periodontal inflammation is associated with a significant increase in Hemoglobin A1c (HbA1c), Fasting Blood Sugar (FBS) and inflammatory factors in patients with diabetes mellitus (15,16).…”

mentioning

confidence: 99%

The Effect of Resveratrol Supplementation in Adjunct with Non-surgical Periodontal Treatment on Blood Glucose, Triglyceride, Periodontal Status and Some Inflammatory Markers in Type 2 Diabetic Patients with Periodontal Disease

et al. 2016

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Relationship between metabolic syndrome and diagnoses of periodontal diseases among participants in a large Taiwanese cohort

Abstract: A small but statistically significant association between MetS and the diagnosis of periodontal diseases was found in Taiwanese women and a weaker association in Taiwanese men.

Cited by 43 publications

References 22 publications

Periodontopathogens, Candida spp. and immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis

Periodontopathogens, Candida spp. and immunological aspects in type 2 diabetes mellitus patients with chronic periodontitis

Periodontal disease and metabolic syndrome: A qualitative critical review of their association

The Effect of Resveratrol Supplementation in Adjunct with Non-surgical Periodontal Treatment on Blood Glucose, Triglyceride, Periodontal Status and Some Inflammatory Markers in Type 2 Diabetic Patients with Periodontal Disease

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