Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET

Nambu, Atsushi; Kato, Satoshi; Sato, Yoko; Okuwaki, Hideto; Nishikawa, Keiichi; Saito, Akitoshi; Matsumoto, Keiko; Ichikawa, Tomoaki; Araki, Tsutomu

doi:10.1007/s12149-009-0237-5

Cited by 46 publications

(46 citation statements)

References 17 publications

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“…These results further suggested that SUVmax may in partly reflect the potential of metastasis in primary tumor in NSCLC and are in line with other studies (Li et al, 2009;Nambu et al, 2009). However, there was no upper threshold of SUVmax of NSCLC, above which lymph node and/or distant organ metastasis were always present.…”

Section: Discussionsupporting

confidence: 92%

“…Metastasis is the major cause of death due to several malignancies, including NSCLC and it occur primary by dissemination through the lymphatic and blood vessels. Nambu et al (2009) have reported that the likelihood of lymph node metastasis increases with increase of SUVmax of the primary tumor in patients with NSCLC. Our results are consistent with their observations.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

Zhu¹,

Zhang²,

Yu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

Zhu¹,

Zhang²,

Yu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Many previous studies concluded that the likelihood of lymph node metastasis increases with an increase in SUV max of the primary tumor (22,23). Our results are not consistent with those observations.…”

Section: Discussioncontrasting

confidence: 99%

Ce-CT versus integreted pet/ct in preoperative nodal staging of non–small cell lung cancer

Ceylan

Dogan²,

Kocacelebi³

et al. 2012

Diagn Interv Radiol

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435N on-small cell lung cancer (NSCLC) accounts for approximately 75% to 85% of all newly diagnosed lung cancers (1). The optimal treatment of NSCLC relies on accurate disease staging, which is based on tumor size, regional nodal involvement, and the presence of metastasis. Correct evaluation of the presence or absence of metastases in mediastinal and hilar lymph nodes is a critical factor that may determine operability and long-term survival in patients with NSCLC. Surgical treatment can be expected in 70% of patients with N0 stage and up to 24% of patients with N2 stage; however, surgery is generally not indicated in patients with N3 stage cancer (2).Although computed tomography (CT) is the most commonly used noninvasive imaging modality for the pre-operative evaluation of tumor size and the extent of invasion into adjacent structures, a number of reviews and meta-analyses have shown the limited reliability of CT in lymph node staging (3). The CT criteria for lymph node tumor involvement rely on the size or shape of the lymph nodes. Usually, 1 cm is used as the size criterion predicting tumor involvement in lymph nodes. However, normal sized lymph nodes may show metastases upon histological examination, and nodal enlargement may be due to reactive hyperplasia or other benign conditions (2). Rapid advances in multi-detector CT scanners allow a more detailed analysis of the lung parenchyma and mediastinal structures. As a consequence, nodal staging may be enhanced with CT.Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) has been reported to improve identification of nodal metastasis. FDG PET images may be more sensitive than CT because alterations in tissue metabolism generally precede anatomical changes (4). Integrated PET-CT provides information about anatomy and metabolism by combining morphological CT data and functional PET data (5). However, falsepositive PET-CT results in nodal staging have been shown in patients with co-existing inflammatory or infectious diseases, and PET-CT scanning may be unable to identify metastatic deposits in normal-sized lymph nodes because of its suboptimal spatial resolution (6, 7).Several retrospective and prospective studies have investigated the effectiveness of CT and PET-CT in pre-operative nodal staging of NSCLC (8-13). However, conflicting conclusions have been reported in these studies. Thus, the aim of our study was to retrospectively evaluate the effectiveness of integrated PET-CT in pre-operative staging of NSCLC in comparison with contrast enhanced CT (CE-CT) by using surgical and pathological findings as the reference standard. Materials and methods Patient populationFrom RESULTS Forty-eight of the 57 patients (84%) had no lymph node involvement (N0), five (9%) were found to have N1 disease, and four (7%) had N2 disease. There was a significant difference between CE-CT and PET-CT for nodal staging of N0 disease (P < 0.05). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of hilar and mediastina...

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“…La probabilité d'atteinte ganglionnaire ou de métastases à distance serait corrélée au SUVmax de la lésion primitive [33][34][35]. Celui-ci pourrait constituer un facteur pronostique au même titre que la classification TNM lors du bilan d'extension initial du CBNPC.…”

Section: Discussionunclassified

Caractérisation de populations tumorales dans les cancers bronchiques non à petites cellules en TEP au FDG en fonction de critères anatomopathologiques et génétiques

Yaagoubi¹,

Perraudeau

Barre

et al. 2015

Médecine Nucléaire

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Relationship between maximum standardized uptake value (SUVmax) of lung cancer and lymph node metastasis on FDG-PET

Abstract: The likelihood of lymph node metastasis increases with an increase of the SUV of a primary lung cancer.

Cited by 46 publications

References 17 publications

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

FDG PET-CT in Non-small Cell Lung Cancer: Relationship between Primary Tumor FDG Uptake and Extensional or Metastatic Potential

Ce-CT versus integreted pet/ct in preoperative nodal staging of non–small cell lung cancer

Caractérisation de populations tumorales dans les cancers bronchiques non à petites cellules en TEP au FDG en fonction de critères anatomopathologiques et génétiques

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