Relationship between low serum vitamin D status and urinary tract infection in children: a case–control study

Hashem, Mahmoudzadeh; Nikibakhsh, Ahmad Ali; Pashapour, Sarvin; Ghasemnejad‐Berenji, Morteza

doi:10.1080/20469047.2020.1771244

Cited by 6 publications

(14 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin D levels presented a descending trend with thriving in our study, but only in children diagnosed with UTI. This finding is inconsistent with other studies evolving around UTI in children so far, which have not found any significant correlation between age and vitamin D levels [15,34]. The children included in our study benefited from continuous vitamin D prophylaxis until the age of two.…”

Section: Discussioncontrasting

confidence: 99%

“…Literature data on this matter is still limited in children. Various studies have reported associations between low serum vitamin D and increased risk of UTI [14,15], with one particular study concluding that serum levels of vitamin D lower than 25 nmol/L can constitute an independent risk factor for UTIs in pediatric populations [16]. However, some authors have reached intriguing conclusions, claiming that vitamin D supplementation can increase the risk of UTIs in children and infants [17,18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

Muntean

Săsăran

2021

Children

View full text Add to dashboard Cite

Vitamin D has emerged as a key factor in innate immunity. Its involvement in the pathogenesis of urinary tract infections (UTIs) has gained a lot of attention recently. The objective of this study is to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and first-time or recurrent UTIs in children. A prospective, case-control study was conducted on 101 pediatric patients, who were divided into two groups: 59 patients with UTIs and 42 age-matched healthy controls. Serum 25(OH)D was determined in each child and expressed in ng/mL. Vitamin D presented significantly lower values in study group subjects than in healthy controls (p < 0.01). Moreover, a significantly higher prevalence of vitamin D insufficiency and deficiency was found in children with UTIs (p < 0.01). Patients with recurrent UTIs presented significantly lower levels of vitamin D than those with first-time UTIs (p = 0.04). Urinary tract abnormalities did not seem to exercise an additional effect upon vitamin D levels within the study group. In conclusion, first-time and recurrent UTIs are associated with lower vitamin D levels. Further studies are necessary to validate our findings, as well as future longitudinal research regarding efficacy of vitamin D supplementation in children with UTIs.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

Muntean

Săsăran

2021

Children

View full text Add to dashboard Cite

show abstract

“…Children with low serum vitamin D levels (< 20 nmol/l) were 3.5 times more likely to develop UTI than those with normal levels. The reported results were later verified in multiple studies ( 102 – 104 ). Yang et al ( 105 ) found, in addition to significantly lower serum vitamin D level in infants with UTI than in healthy infants, that vitamin D supplementation is associated with a decreased likelihood of UTI.…”

Section: Resultssupporting

confidence: 57%

A Systematic Review of the (Un)known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection

Hosman

Roić²,

Lamot³

2022

Front. Med.

View full text Add to dashboard Cite

Recurrent urinary tract infections (rUTI) represent a major healthcare and economic burden along with a significant impact on patient’s morbidity and quality of life, even in the absence of well-known risk factors, such as vesicoureteral reflux. Despite numerous attempts to find a suitable therapeutic option, there is no clear benefit of any currently available intervention for prevention of UTI recurrence and its long-term consequences such as hypertension, renal scarring and/or insufficiency. The common treatment practice in many centers around the globe involves the use of continuous low-dose antibiotic prophylaxis, irrespective of various studies indicating increased microbial resistance against the prophylactic drug, leading to prolonged duration and escalating the cost of UTI treatment. Moreover, the rapid appearance of multi-drug resistant uropathogens is threatening to transform UTI to untreatable disease, while impaired host-microbiota homeostasis induced by a long-term use of antibiotics predisposes patients for various autoimmune and infectious diseases. New biomarkers of the increased risk of UTI recurrence could therefore assist in avoiding such outcomes by revealing more specific patient population which could benefit from additional interventions. In this light, the recent findings suggesting a crucial role of urothelial innate immunity mechanisms in protection of urinary tract from invading uropathogens might offer new diagnostic, prognostic and even therapeutic opportunities. Uroepithelial cells detect uropathogens via pattern recognition receptors, resulting in activation of intracellular signaling cascade and transcription factors, which ultimately leads to an increased production and secretion of chemokines, cytokines and antimicrobial peptides into the urinary stream. Emerging evidence suggest that the disturbance of a single component of the urinary tract innate immunity system might increase susceptibility for rUTI. The aim of the current review is to update clinicians and researchers on potential biomarkers of host immune response alterations predisposing for rUTI and propose those well worth exploring further. For this purpose, over a hundred original papers were identified through an extensive PubMed and Scopus databases search. This comprehensive review might enrich the current clinical practice and fill the unmet clinical needs, but also encourage the development of therapeutic agents that would facilitate urinary bacterial clearance by enhancing the host immune response.

show abstract

“…However, in the same study a prevalence of infection was reported higher in girls than boys, which is a known risk factor, and agrees with our observations as more than half of our patients (59%) were female too. This is in accordance with some studies that found significantly lower 25 (OH)D levels in children with UTI compared to controls and supports that VitD deficiency is a risk factor for UTI and especially in girls (12,(197)(198)(199).…”

Section: Utisupporting

confidence: 92%

The effect of breastfeeding and vitamin D status on the susceptibility of infants to infections

Zisi¹,

Ζήση²

View full text Add to dashboard Cite

ΣΚΟΠΟΣ: Η διερεύνηση της σχέσης ή μη της βιταμίνης D σε νοσηλευόμενα παιδιά κάτω των 2 ετών με ενεργό λοίμωξη (ανώτερου και κατώτερου αναπνευστικού, γαστρεντερικού και ουροποιητικού συστήματος). Επίσης, η διερεύνηση επιδράσεων του αποκλειστικού μητρικού θηλασμού, της εποχής αλλά και της εξωγενούς χορήγησης βιταμίνης D στην εμφάνιση των υπό μελέτη λοιμώξεων. ΜΕΘΟΔΟΣ: Το δείγμα περιλάμβανε βρέφη και παιδιά ηλικίας κάτω των 2 ετών με κοινές παιδικές λοιμώξεις που νοσηλεύτηκαν, κατά τη διάρκεια 2 ετών. Ως ομάδα ελέγχου (μάρτυρες) χρησιμοποιήθηκαν μια ομάδα κλινικά υγιών παιδιών παρόμοιας ηλικίας και φύλου. Χρησιμοποιήθηκαν δομημένα ερωτηματολόγια για την καταγραφή κλινικών χαρακτηριστικών όπως ηλικία, γένος, ηλικία κύησης, βάρος γέννησης, είδος τοκετού και είδος διατροφής (αποκλειστικός μητρικός θηλασμός, βρεφικό γάλα, μικτή διατροφή), συμπλήρωμα ή όχι βιταμίνης D. Μέτρηση και σύγκριση των επιπέδων της 25(OH)D στον ορό μεταξύ ασθενών και μαρτύρων. Συγκεντρώσεις στον ορό 25(OH)D≥20ng/ml θεωρήθηκαν επαρκείς. Διαφορές με p≤0,05 θεωρήθηκαν στατιστικώς σημαντικές. ΑΠΟΤΕΛΑΣΜΑΤΑ-ΣΥΜΠΕΡΑΣΜΑΤΑ: Η ομάδα μελέτης αποτελούνταν από 316 ασθενείς (95 με λοίμωξη ανώτερου αναπνευστικού, 99 με λοίμωξη κατώτερου αναπνευστικού, 61 με γαστρεντερίτιδα, 61 με λοιμώξεις ουροποιητικού) και 133 υγιείς μάρτυρες. Η πλειοψηφία των βρεφών και των μικρών παιδιών που νοσηλεύτηκαν δεν έχουν ανεπάρκεια βιταμίνης D πιθανώς λόγω της εξωγενούς πρόσληψης βιταμίνης D (400IU/d) από τις πρώτες μέρες γέννησή τους, ειδικά για αυτά που θηλάζουν αποκλειστικά. Η βιταμίνη D δεν διέφερε στα παιδιά με τις λοιμώξεις που μελετήσαμε από ότι στα παιδιά μάρτυρες που δείχνει ότι η βιταμίνη D δεν φαίνεται να έχει επίδραση στη συχνότητα αυτών των λοιμώξεων. Δεν βρέθηκαν διαφορές στα επίπεδα βιταμίνης D στον ορό των βρεφών με λοιμώξεις και στους μάρτυρες μεταξύ των δύο περιόδων (εποχές), εκτός της γαστρεντερίτιδας, ενώ υπήρξε σημαντική διαφορά στη συχνότητα των λοιμώξεων και ειδικότερα του κατώτερου αναπνευστικού όπου ήταν πιο μεγάλη την περίοδο χειμώνα/άνοιξη. Στη γαστρεντερίτιδα παρά την υψηλότερη 25(OH)D το καλοκαίρι/φθινόπωρο υπήρξε και ψηλότερη συχνότητα νόσησης απ' ότι το χειμώνα/άνοιξη. Σχετικά με συγκρίσεις μεταξύ της συχνότητας των παιδιών με ανεπάρκεια βιταμίνης D ή μη, δε βρέθηκαν διαφορές μεταξύ των ομάδων ασθενών και μαρτύρων. Ο αποκλειστικός μητρικός θηλασμός δεν φαίνεται να επηρεάζει προς το καλύτερο τα ποσοστά των λοιμώξεων μεταξύ των ομάδων. Ωστόσο ο αριθμός των βρεφών υπό αποκλειστικό ΜΘ ήταν σχετικά μικρός για να μπορέσει να αξιολογηθεί επαρκώς και να αμφισβητήσει τα πλεονεκτήματα του ΜΘ επίσης, δείχνει ότι στην Ελλάδα το ποσοστό ΜΘ είναι πολύ χαμηλό. Επιπλέον, τα επίπεδα της 25(ΟΗ)D στον ορό δεν διέφεραν μεταξύ των ασθενών και μαρτύρων σε σχέση με το είδος της σίτισης πιθανότατα λόγω λήψης συμπληρώματος βιταμίνης D. Δεν βρέθηκε διαφορά στα ποσοστά λοίμωξης μεταξύ παιδιών που λάμβαναν και αυτών που δεν λάμβαναν συμπλήρωμα βιταμίνης D. Παρ 'όλα αυτά, τα επίπεδα 25(ΟΗ)D ήταν σημαντικά υψηλότερα στα παιδιά που λάμβαναν συμπλήρωμα.

show abstract

Relationship between low serum vitamin D status and urinary tract infection in children: a case–control study

Cited by 6 publications

References 34 publications

Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

Vitamin D Status and Its Role in First-Time and Recurrent Urinary Tract Infections in Children: A Case-Control Study

A Systematic Review of the (Un)known Host Immune Response Biomarkers for Predicting Recurrence of Urinary Tract Infection

The effect of breastfeeding and vitamin D status on the susceptibility of infants to infections

Contact Info

Product

Resources

About