Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations

Stawerska, Renata; Smyczyńska, Joanna; Hilczer, Maciej; Lewiński, Andrzej

doi:10.1155/2017/5713249

Cited by 13 publications

(23 citation statements)

References 48 publications

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“…Concerning the present results of BMI,they are similar to those of other studies [24,25] which reported non-significant differences in BMI between the GH deficient patients and the control group,while theyare indisagreement with other reports [29] . The reason might be that BMI depends on the weight and height and thatit is not clear whether there is a similar association between BMI and peak GH level in healthy children [24].…”

Section: Anthropometric Measurements Of Ghdeficient Patients and The supporting

confidence: 92%

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Aldabagh

Al-Lami

Al-Samarriae

2020

eijs

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The present study aims to evaluate levels of calcium regulating hormones and some biochemical parameters in a sample of growth hormone (GH) deficient patients. Seventy five GH deficient patients and twenty healthy subjects used as a control group have been involved in this study during their attendance at the National Diabetic Centerfor Treatment and Research /Al-Mustansiriya University. The studied subjects were in an age range of 3-15 years. Blood samples were collected from the studied subjects to determine levels of basal GH,GH 2. and GH 3 after 60 mins. and 90mins. of provocation with clonidine. The study also included the measurement of the levels of insulin like growth factor (IGF-1); calcium regulating hormones [parathyroid hormone (PTH) and vitamin D],and some biochemical parameters [calcium (Ca), phosphorus (P), urea, and creatinine].Distribution of the studied groups according to gender revealed that most of the GH deficientpatients (60 %) were males while 40 % were females,with the difference being statistically significant (P<0.05), while the control included two equal subgroups (50 % males and 50 % females). Distribution of the studied groups according to BMI values showed that the percentage of underweight was significantly (P<0.01) higher in the patients (48%) compared to the control (10%), while the percentage of normal weight was significantly (P<0.01) higher in the control (85%) as compared to the patients (40%).The results showed highly significant decreases (P<0.01) in the levels of basal GH, GH 2 and GH 3 in the patients as compared to the control group. Also, IGF-1 levels showed a high significant (P<0.01) decrease in the patients as compared to the control group.The findings of calcium regulating hormones revealed non-significant differences in the levels of PTH and vitamin D between the patients and the control group. Also, the results of the biochemical parameters (Ca, P, urea, and creatinine) showed non-significant differences in their values between the patients and the control group.It can be concluded from the present study that GH deficiency (GHD) seems to be dominating in the males under weighted patients. The diagnosis of GHD cannot be achieved at the basal GH level.IGF-1 is a reliable marker of GH functions. Finally, levels of calcium regulating hormones are not affected by GHD.

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Section: Anthropometric Measurements Of Ghdeficient Patients and The supporting

confidence: 92%

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Aldabagh

Al-Lami

Al-Samarriae

2020

eijs

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“…Its endocrine function could be partially modulated by the GH/ IGF-1 axis and adipokines derived from adipose tissue possibly mediate some metabolic actions of GH, such as the influence on energy balance and glucose and lipid metabolism (Kershaw et al, 2004;Trayhurn et al, 2006;Berryman et al, 2011;Meazza et al, 2014;Ciresi et al, 2016;Rothermel et al, 2016;Berryman et al, 2017). Several studies indicate that in patients with GHD, both children and adults, the adipokine profile could be impaired, and GH replacement therapy could be beneficial, but the reported results are discordant (Ciresi et al, 2007;Nozue et al, 2007;Andersson et al, 2009;Ciresi et al, 2016;Oświęcimska et al, 2017;Stawerska et al, 2017). Concentrations of adiponectin seem to be unaffected in children with untreated GHD (Ciresi et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Resistin concentrations in untreated GH-deficient children are usually higher than in healthy controls, but the effects of GH treatment on resistin concentrations are divergent (Nozue et al, 2007;Meazza et al, 2014;Ciresi et al, 2016;Stawerska et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…The discrepancy in the results of different studies evaluating the adipokine profile in untreated patients with GHD could be a result of varied metabolic panel reported in those children by several authors, who indicate that not all children with GHD have an impaired metabolic profile (Gleeson et al, 2007;López-Siguero et al, 2011;Meazza et al, 2014;Ciresi et al, 2016;Stawerska et al, 2017). Data concerning chang-es in the lipid profile, glucose homeostasis and thyroid function were also divergent (van der Sluis et al, 2002;Andersson et al, 2009;Smyczyńska et al, 2010;López-Siguero et al, 2011;Ciresi et al, 2016;Giavoli et al, 2017;Oświęcimska et al, 2017;Stawerska et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have confirmed the link between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and adipose tissue (Nilsson et al, 2005;Ciresi et al, 2007;Willemsen et al, 2007;Andersson et al, 2009;Vijayakumar et al, 2010;López-Siguero et al, 2011;Meazza et al, 2014;Orrù et al, 2017;Stawerska et al, 2017). The influence of GH on adipose tissue includes changes in its endocrine function, as well as alterations in body composition (Kuromaru et al, 1999;Sas et al, 2000;van der Sluis et al, 2002;Ciresi et al, 2016;Matusik et al, 2016;Rothermel et al, 2016).…”

Section: Introductionmentioning

confidence: 94%

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The associations between the growth hormone/insulin-like growth factor-1 axis, adiponectin, resistin and metabolic profile in children with growth hormone deficiency before and during growth hormone treatment

et al. 2018

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This study investigated associations between the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis, adiponectin, resistin and metabolic profile in 47 GH-deficient children before and during 12 months of GH treatment. 23 short age-matched children without growth hormone deficiency (GHD) or any genetic or chronic disorders were recruited as controls at baseline. Metabolic evaluation included measurements of adiponectin, resistin, IGF-1, total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), glucose, insulin, glycated haemoglobin (HbA1c), thyroid stimulating hormone (TSH) and free thyroxine (free T4) concentrations. The GH-deficient children had significantly higher adiponectin (p<0.05) and total cholesterol (p<0.05) levels, and a significantly lower level of resistin (p<0.05) than the controls. Resistin at 6 months of GH treatment significantly correlated with changes in height SDS in that period (r=0.35) and with the level of fasting insulin (r=0.50), the HOMA-IR (r=0.56) and the QUICKI (r=-0.53) at 12 months of therapy. Adiponectin level at 12 months of GH treatment was significantly associated with changes in HDL-C within the first 6 (r=0.73) and within 12 (r=0.56) months of therapy, while resistin significantly correlated with an increment in IGF-1 within 12 months of treatment (r=0.49) and with total-C at 12 months (r=0.56). Untreated GH-deficient children had higher adiponectin and lower resistin levels than healthy short children without GHD. Adiponectin and resistin levels did not change significantly during the first 12 months of GH therapy. Good responders to GH treatment had a tendency for higher resistin level during GH therapy, which positively correlates with the insulin resistance parameters.

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Lipotoxicity suppresses the synthesis of growth hormone in pituitary somatotrophs via endoplasmic reticulum stress

Gong

Yang

Wei

et al. 2021

J Cellular Molecular Medi

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Relationship between IGF-I Concentration and Metabolic Profile in Children with Growth Hormone Deficiency: The Influence of Children’s Nutritional State as well as the Ghrelin, Leptin, Adiponectin, and Resistin Serum Concentrations

Cited by 13 publications

References 48 publications

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

The associations between the growth hormone/insulin-like growth factor-1 axis, adiponectin, resistin and metabolic profile in children with growth hormone deficiency before and during growth hormone treatment

Lipotoxicity suppresses the synthesis of growth hormone in pituitary somatotrophs via endoplasmic reticulum stress

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