Relationship between hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men

Chang, Chung‐Hsin; Chen, Yiming; Chuang, Ya‐Wen; Liao, Szu-Chia; Lin, Chu-Sheng; Tang, Yih-Jing; Sheu, Wayne H‐H; Chen, Der‐Yuan

doi:10.1016/s0167-4943(09)70013-5

Cited by 18 publications

(12 citation statements)

References 14 publications

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“…Indeed, a growing body of evidence implicates sugar intake as a risk factor for gout (75). Moreover, elevated serum uric acid levels and gout are associated with other cardiometabolic risk factors in diverse populations (76)(77)(78). A substantial body of work suggests that increased uric acid levels may independently regulate important aspects of metabolism and contribute to cardiometabolic risk (79)(80)(81)(82)(83).…”

Section: Genetic Lessons About Fructose Metabolismmentioning

confidence: 99%

Fructose metabolism and metabolic disease

Hannou

Haslam

McKeown

et al. 2018

Journal of Clinical Investigation

403

356

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Section: Genetic Lessons About Fructose Metabolismmentioning

confidence: 99%

Fructose metabolism and metabolic disease

Hannou

Haslam

McKeown

et al. 2018

Journal of Clinical Investigation

403

356

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“…Insulin resistance is considered to be the key mechanism of MetS [1, 42–44], but it is difficult to be quantified. In order to increase predictive power, some experts suggest that more related biomarkers may be needed, such as high-sensitivity C-reactive protein, uric acid, and other inflammation marker [36, 45–48]. …”

Section: Reliable Markers Of the Renal Injurymentioning

confidence: 99%

Metabolic Syndrome and Renal Injury

Sheen

Sheu²

2011

Cardiology Research and Practice

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Both metabolic syndrome (MetS) and chronic kidney disease (CKD) are major global health issues. Current clinical markers used to reflect renal injury include albuminuria and estimated glomerular filtration rate (eGFR). Given the same eGFR level, urine albumin might be a better risk marker to predict progression of CKD and future development of cardiovascular diseases (CVDs). Serum Cystatin C is emerging as a new biomarker for early detection of renal injury associated with MetS and cardiovascular risk. In addition to each component, MetS per se influences the incidence and prognosis of renal injury and the odds ratios increased with the increase in the number of metabolic abnormalities. Hyperinsulinemia, activation of rennin-angiotensin-aldosterone system, increase of oxidative stress, and inflammatory cytokines are proposed to be the plausible biological link between MetS and CKD. Weight control, stick control of blood pressure, glucose, and lipids disorders may lead to lessening renal injury and even the subsequent CVD.

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“…SUA was positively associated with IL-6, TNF- α and CRP in 957 elderly people in Italy [17] and SUA predicted CRP increase during follow-up [18]. By contrast, SUA was not associated with IL-6, TNF- α and CRP in 333 elderly men in Taiwan [19].…”

Section: Introductionmentioning

confidence: 98%

Elevated Serum Uric Acid Is Associated with High Circulating Inflammatory Cytokines in the Population-Based Colaus Study

et al. 2011

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BackgroundThe relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have been inconsistent. We analyzed the association between SUA and circulating levels of interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor- α (TNF-α) and C-reactive protein (CRP).Methods and FindingsThis cross-sectional population-based study conducted in Lausanne, Switzerland, included 6085 participants aged 35 to 75 years. SUA was measured using uricase-PAP method. Plasma TNF-α, IL-1β and IL-6 were measured by a multiplexed particle-based flow cytometric assay and hs-CRP by an immunometric assay. The median levels of SUA, IL-6, TNF-α, CRP and IL-1β were 355 µmol/L, 1.46 pg/mL, 3.04 pg/mL, 1.2 mg/L and 0.34 pg/mL in men and 262 µmol/L, 1.21 pg/mL, 2.74 pg/mL, 1.3 mg/L and 0.45 pg/mL in women, respectively. SUA correlated positively with IL-6, TNF-α and CRP and negatively with IL-1β (Spearman r: 0.04, 0.07, 0.20 and 0.05 in men, and 0.09, 0.13, 0.30 and 0.07 in women, respectively, P<0.05). In multivariable analyses, SUA was associated positively with CRP (β coefficient ± SE = 0.35±0.02, P<0.001), TNF-α (0.08±0.02, P<0.001) and IL-6 (0.10±0.03, P<0.001), and negatively with IL-1β (−0.07±0.03, P = 0.027). Upon further adjustment for body mass index, these associations were substantially attenuated.ConclusionsSUA was associated positively with IL-6, CRP and TNF-α and negatively with IL-1β, particularly in women. These results suggest that uric acid contributes to systemic inflammation in humans and are in line with experimental data showing that uric acid triggers sterile inflammation.

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Relationship between hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men

Cited by 18 publications

References 14 publications

Fructose metabolism and metabolic disease

Fructose metabolism and metabolic disease

Metabolic Syndrome and Renal Injury

Elevated Serum Uric Acid Is Associated with High Circulating Inflammatory Cytokines in the Population-Based Colaus Study

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