Relationship between higher serum selenium level and adverse blood lipid profile

Wen, Jianping; Ji, Mei; Li, Xia; Li, Zhe; Wu, Guanrui; Fu, Xiuwei; Yang, Xiaomei; Gao, Xibao

doi:10.1016/j.clnu.2017.08.025

Cited by 54 publications

(33 citation statements)

References 39 publications

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“…The association between selenium and other components of MetS beyond hyperglycemia has been less studied. Consistent with our findings that higher selenium was associated with higher odds of 7 Oxidative Medicine and Cellular Longevity hypertriglyceridemia and lower odds of low HDL-C, a recent study also revealed positive associations of selenium with triglyceride and HDL-C [27]. However, our findings that the inverse association between selenium and low HDL-C was significantly stronger in men than in women was contrary to a previous study that revealed that selenium was inversely related with HDL-C only in women [28].…”

Section: Discussionsupporting

confidence: 92%

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Zhou

Luo

Yin

et al. 2020

Oxidative Medicine and Cellular Longevity

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The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine the associations of plasma selenium concentrations and selenoprotein P rs7579 polymorphism with MetS, a case-control study of 1279 MetS cases and 1279 sex- and age- (±2 years) matched controls was conducted based on the baseline data of the Tongji-Ezhou Cohort study. Plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry. MetS was defined using the definition of the Joint Interim Statement, adjusted for the Chinese population. In addition, the rs7579 polymorphism was genotyped by the Agena MassARRAY System. Plasma selenium concentrations in the MetS group were higher than in the control group (93.88 μg/L (83.17-107.41) vs. 92.66 μg/L (82.36-103.53), P<0.05). Compared with quartile 4 (≥103.53 μg/L), the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) associated with MetS were 0.79 (0.59-1.06) for quartile 1 (<82.36 μg/L), 0.75 (0.56-1.01) for quartile 2 (82.37-92.66 μg/L), and 0.61 (0.45-0.83) for quartile 3 (92.67-103.52 μg/L). The cubic spline analyses revealed a U-shaped association between plasma selenium and MetS, with the lowest risk at around 93.69 μg/L. Moreover, in cubic spline analyses, plasma selenium showed U-shaped associations with central obesity and high blood pressure, positive associations with hypertriglyceridemia and hyperglycemia, and a negative association with low high-density lipoprotein cholesterol. Additionally, both the GA and GA+AA genotype carriers were associated with increased ORs of MetS comparing with the GG genotype carriers. Our findings suggested a U-shaped association between plasma selenium and MetS and diverse associations between plasma selenium and components of MetS. Furthermore, our study found that the A allele of rs7579 was associated with higher odds of MetS. Further studies are needed to confirm our findings and elucidate the underlying mechanisms.

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Section: Discussionsupporting

confidence: 92%

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Zhou

Luo

Yin

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…fied analyses, the authors found that the higher serum selenium increased odds ratio for dyslipidemia of 2.76 among the postmenopausal women and odds ratio of 9.4 in the subjects with diabetes [41]. A double-blinded randomized clinical trial which lasted for 3 months revealed that the selenium consumption was not effective in changing the lipid profile of hemodialysis patients [42].…”

Section: Lipid Profilementioning

confidence: 99%

Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis

et al. 2018

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Selenium is an essential mineral that plays a key role in plenty of major metabolic processes. A growing body of literature has shown that selenium deficiency leads to an increase in plasma TC and TG levels. This study explores the effect of selenium supplementation on serum level of lipid profile [total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), very low density lipoprotein (VLDL)]. We systematically searched PubMed/MEDLINE, ISI/WOS, and Scopus (from their commencements to Jan 2016) to identify the papers investigating the association between the intake of selenium and lipid profile. Data extracted from the relevant studies were screened. The pooled standardized mean difference was estimated using the random or fixed effects model. Heterogeneity among the studies was assessed using Q-test. Of the potentially relevant articles screened, 11 articles including 1221 participants were included in this meta-analysis. Results of meta-analysis showed that intake of selenium resulted in a statistically significant improvement in TC, [(SMD): –0.13, 95% CI: (–0.24, –0.02)], TG [(SMD): –0.19, 95% CI: (–0.38, –0.01)] and VLDL [(SMD): –0.34, 95% CI: (–0.63, –0.05)]. The selenium supplementation did not significantly improve lipid profile such as LDL [(SMD): –0.08, 95% CI: (–0.036, 0.19)], HDL [(SMD): 0.01, 95% CI: (–0.164, 0.18)], HDL/TC ratio [(SMD): 0.025, 95% CI: (–0.11, 0.16)], non-HDL-C [(SMD): 0.018, 95% CI: (–0.13, 0.16)]. This meta-analysis suggests that the effect of selenium supplementation on the serum levels of TG and VLDL is marginally significant. However, the supplementation has no effect on other serum lipids. Moreover, the study shows that the effect of selenium supplementation on lipid profile is negative.

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“…The trace element also stands out for its participation in immunological competence, particularly in cell-mediated immunity, cognitive function, and protection against cardiovascular diseases (CVDs) [5,6].…”

Section: Introductionmentioning

confidence: 99%

Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

Andrade

Souza

Fonseca

et al. 2021

Orphanet J Rare Dis

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Introduction Ataxia-Telangiectasia (A-T) is a multi-system disorder that may be associated with endocrine changes, oxidative stress in addition to inflammation. Studies suggest that selenium is a trace element related to protection against damage caused by oxidative stress. Objective To describe the plasma levels of selenium and erythrocyte glutathione peroxidase activity in A-T patients and to relate them to oxidative stress and lipid status biomarkers. Methods This is a cross-sectional and controlled study evaluating 22 A-T patients (age median, 12.2 years old) matched by gender and age with 18 healthy controls. We evaluated: nutritional status, food intake, plasma selenium levels, erythrocyte glutathione peroxidase activity, lipid status, inflammation and oxidative stress biomarkers. Results Adequate levels of selenium were observed in 24/36 (66.7%) in this evaluated population. There was no statistically significant difference between the groups in selenium levels [47.6 μg/L (43.2–57.0) vs 54.6 (45.2–62.6) μg/dL, p = 0.242]. Nine of A-T patients (41%) had selenium levels below the reference value. The A-T group presented higher levels of LDL-c, non-HDL-c, oxidized LDL, Apo B, Apo-B/Apo-A-I1, LDL-c/HDL-c ratio, malondialdehyde [3.8 µg/L vs 2.8 µg/L, p = 0.029] and lower Apo-A-I1/HDL-c and glutathione peroxidase activity [7300 U/L vs 8686 U/L, p = 0.005]. Selenium levels were influenced, in both groups, independently, by the concentrations of oxidized LDL, malonaldehyde and non-HDL-c. The oxidized LDL (AUC = 0.849) and ALT (AUC = 0.854) were the variables that showed the greatest discriminatory power between groups. Conclusion In conclusion, we observed the presence of selenium below the reference value in nearly 40% and low GPx activity in A-T patients. There was a significant, inverse and independent association between selenium concentrations and oxidative stress biomarkers. Those data reinforce the importance of assessing the nutritional status of selenium in those patients.

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Relationship between higher serum selenium level and adverse blood lipid profile

Cited by 54 publications

References 39 publications

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene Polymorphism with Metabolic Syndrome and Its Components

Effect of Selenium Supplementation on Lipid Profile: A Systematic Review and Meta-Analysis

Selenium levels and glutathione peroxidase activity in patients with ataxia-telangiectasia: association with oxidative stress and lipid status biomarkers

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