Relationship between ethanol preference and sensation/novelty seeking

Manzo, Lidia; Gómez, M. J. Martínez; Callejas-Aguilera, José E.; Donaire, Rocío; Sabariego, Marta; Fernández-Teruel, Alberto; Cañete, Antoni; Blázquez, Gloria; Papini, Mauricio R.; Torres, Carmen

doi:10.1016/j.physbeh.2014.05.003

Cited by 48 publications

(22 citation statements)

References 73 publications

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“…These results suggest that RHA-I rats are in tune with environmental events, whereas RLA-I rats are prone to react emotionally to changes in the environment. This is also shown in situations involving exploratory behavior, in which RHA-I rats are prone to explore and RLA-I rats tend to freeze (López-Aumatell, Vicens-Costa et al, 2009;Manzo, Gómez, Callejas-Aguilera, Donaire et al, 2014). We suggest here that these strain differences extend to the ability to profit from previous emotional learning, an ability that is suggested to be more salient for RLA-I rats than for RHA-I rats.…”

Section: Transfer Effects In Rha-i Ratssupporting

confidence: 55%

Transfer across reward devaluation tasks in inbred Roman rat strains

Cuenya

Sabariego

Donaire

et al. 2015

Learning and Motivation

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Section: Transfer Effects In Rha-i Ratssupporting

confidence: 55%

Transfer across reward devaluation tasks in inbred Roman rat strains

Cuenya

Sabariego

Donaire

et al. 2015

Learning and Motivation

Self Cite

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“…Rather than a high anxiety/ stress reactive and high drinking phenotype, the HDID-1 mice may instead show more similarity to novelty-seeking or sensation-seeking at-risk human drinkers. Both novelty seeking and sensation seeking have been demonstrated to be associated with risk for AUDs and excessive drinking (Lange, Kampov-Polevoy, & Garbutt, 2010; Manzo et al, 2014; Noël et al, 2011), and it would be interesting to test the HDID-1 mice on a measure of novelty seeking to determine whether this behavior is associated with binge-like drinking in these animals.…”

Section: Discussionmentioning

confidence: 99%

Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice

Barkley-Levenson

Crabbe

2015

Alcohol

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Alcohol use disorders (AUDs) and anxiety disorders are highly comorbid in humans. In rodent lines selected for alcohol drinking, differences in anxiety-like behavior have also been seen. The High Drinking in the Dark (HDID) lines of mice have been selectively bred for drinking to intoxication during limited access to alcohol, and these mice represent a genetic model of risk for binge-like drinking. The present studies sought to determine whether these selected lines differ in basal anxiety or in anxiolytic response to alcohol, and if so, whether these differences might contribute to the high drinking phenotype. We also assessed the genetic correlation between alcohol drinking in the dark (DID) and basal anxiety-like behavior using existing inbred strain data. Male and female mice of both HDID replicates (HDID-1 and HDID-2) were tested on an elevated zero maze (EZM) immediately following a DID test. HDID mice of both replicates and sexes showed more time spent in the open arms after drinking alcohol than HS mice, and open-arm time was significantly correlated with blood alcohol concentration. HDID-1 male mice also showed less anxiety-like behavior at baseline (water-drinking controls). In a separate experiment, HDID-1 and HS mice were tested for anxiolytic dose–response to acute alcohol injections. Both genotypes showed increasing time spent in the open arms with increasing alcohol doses, and HDID-1 and female mice had greater open-arm time across all doses. HDID-1 male saline-treated control animals showed lower baseline anxiety-like behavior than the HS control males. Inbred strain data analysis also showed no significant genetic relationship between alcohol DID and anxiety. These findings suggest that selection for drinking to intoxication has not produced systematic changes in anxiety-like behavior or sensitivity to alcohol-induced anxiolysis in the HDID animals, though there is a tendency in the male mice of the first replicate toward reduced basal anxiety-like behavior. Therefore, anxiety state and sensitivity to alcohol's anxiolytic effects do not appear to contribute significantly to the high drinking behavior of the HDID mice under these conditions.

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“…Zheng and colleagues demonstrated that the response to novelty in both juvenile and adult Sprague-Dawley rats determined the magnitude of morphine’s rewarding effects (Zheng et al, 2003). Finally, studies show a positive correlation between ethanol self-administration and novelty-seeking behavior (Nadal et al, 2002; Manzo et al, 2014). Pelloux and colleagues recently demonstrated that novelty seeking strongly predicted the amount of ethanol consumption among Wistar rats (Pelloux et al, 2015).…”

Section: Behavioral Connection Between Novelty Seeking and Addictionmentioning

confidence: 99%

“…In rodents, novelty seeking has been defined as a preference for novel objects or environments; high novelty-seeking rodents display enhanced exploratory behavior toward novel situations, objects, or stimuli (Piazza et al, 1989). In rats and mice, preference for novelty has been correlated with higher sensitivity to the reinforcing effects of many drugs of abuse, including amphetamine, cocaine, nicotine, and alcohol (Piazza et al, 1989; Hooks et al, 1991; Ambrosio et al, 1995; Suto et al, 2001; Nadal et al, 2002; Belin and Deroche-Gamonet, 2012; Manzo et al, 2014). Measuring novelty-seeking behavior in rodent models that mimic human psychiatric disorders including addiction will help to elucidate the neurobehavioral details of psychopathological conditions.…”

Section: Definition Of Novelty Seekingmentioning

confidence: 99%

“…In rodents, reactivity to novel stimuli correlates with drug self-administration and drug-seeking behaviors (Piazza et al, 1989; Blanchard et al, 2009; Flagel et al, 2010). After rats are categorized as high or low responders on the basis of behavioral reactivity to a novel environment, high-responder rats consistently self-administer drugs such as amphetamine, cocaine, nicotine, and alcohol at higher rates than do low responders (Piazza et al, 1989; Hooks et al, 1991; Ambrosio et al, 1995; Suto et al, 2001; Nadal et al, 2002; Belin and Deroche-Gamonet, 2012; Manzo et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

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Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules

Wingo

Nesil

Choi

et al. 2015

J Neuroimmune Pharmacol

129

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Global treatment of drug addiction costs society billions of dollars annually, but current psychopharmacological therapies have not been successful at desired rates. The increasing number of individuals suffering from substance abuse has turned attention to what makes some people more vulnerable to drug addiction than others. One personality trait that stands out as a contributing factor is novelty seeking. Novelty seeking, affected by both genetic and environmental factors, is defined as the tendency to desire novel stimuli and environments. It can be measured in humans through questionnaires and in rodents using behavioral tasks. On the behavioral level, both human and rodent studies demonstrate that high novelty seeking can predict the initiation of drug use and a transition to compulsive drug use and create a propensity to relapse. These predictions are valid for several drugs of abuse, such as alcohol, nicotine, cocaine, amphetamine, and opiates. On the molecular level, both novelty seeking and addiction are modulated by the central reward system in the brain. Dopamine is the primary neurotransmitter involved in the overlapping neural substrates of both parameters. In sum, the novelty-seeking trait can be valuable for predicting individual vulnerability to drug addiction and for generating successful treatment for patients with substance abuse disorders.

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Relationship between ethanol preference and sensation/novelty seeking

Cited by 48 publications

References 73 publications

Transfer across reward devaluation tasks in inbred Roman rat strains

Transfer across reward devaluation tasks in inbred Roman rat strains

Genotypic and sex differences in anxiety-like behavior and alcohol-induced anxiolysis in High Drinking in the Dark selected mice

Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules

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