Relationship Between Dietary Fiber and Vitamin C Intake and Oral Cancer

Abstract

BackgroundDietary fiber and vitamin C has been reported to play a possible role in tumorigenesis. However, few studies have estimated their association with oral cancer risk. In this project, we investigated the relationship between dietary fiber and vitamin C and oral cancer risk in adults in Southern China.Methods382 patients newly diagnosed with oral cancer were matched to 382 hospital derived controls by frequency matching in age and sex. Pre-diagnostic consumption of dietary fiber and vitamin C intake were measured through food frequency questionnaire. Association between nutrients intake and oral cancer risk were evaluated by logistic regression. OR value and 95% confidence interval was calculated.ResultsIntake of dietary fiber and vitamin C was significantly lower in oral cancer patients (8.15 g/day) than in control participants (8.88 g/day). Increased dietary fiber or vitamin C intake was linked to a decreased incidence of OC after adjustment of age, marital status, residence, BMI, occupation, education, tobacco smoking, alcohol consumption and family history of cancer Ptrend< 0.001). Compared with the lowest tertile, the adjusted OR of the top tertile of dietary fiber was 0.47 (95 % CI 0.32, 0.68). While the adjusted OR of the highest tertile was 0.60 (95 % CI 0.42, 0.87) compared with the lowest tertile of vitamin C.ConclusionsDietary intake of fiber and vitamin C were lower in oral cancer patients than in control participants. Dietary fiber and vitamin C were inversely related to risk of oral cancer risk.

Oxidative Stress in the Pathogenesis of Oral Cancer

“…Following a similar trajectory, a case–control examination conducted in southeastern China, with 382 oral cancer patients and 382 matched controls, revealed a significant association between dietary fiber, vitamin C intake, and oral cancer risk. Individuals with higher intakes of dietary fiber and vitamin C had substantially lower odds of developing oral cancer, with a 53% and 40% reduction in risk, respectively ( Table 1 ) [ 62 ]. Healthcare providers may consider the integration of biomarker testing into OSCC screening and monitoring protocols.…”

Let food be your medicine – dietary fiber

“…139 Interestingly, numerous studies have also demonstrated that human dietary intake of DF reduces the incidence of several other cancers, including oral, prostate, liver, and breast. [140][141][142][143] Many studies suggest that the gut microbiota may act as transmitters of DF-inhibiting cancer signals. Mushroom polysaccharides (MP) may fulfill colon cancer preventive and therapeutic functions by dynamically regulating host immune responses.…”

“…139 Interestingly, numerous studies have also demonstrated that human dietary intake of DF reduces the incidence of several other cancers, including oral, prostate, liver, and breast. 140–143…”

Interaction of Dietary Fiber, Genetic Variants and Diseases: Systematic Review

“…Posa ve C vitamini alımının, ağız kanseri hastalarında (8,15 g/gün) kontrol grubuna (8,88 g/gün) göre önemli ölçüde daha düşük olduğu sonucuna varılmıştır. 14 Uzun süre yetersiz diyet posası alımının, inflamasyon için önemli bir risk faktörü olduğu bilinmektedir. Yetersiz posa alımı, sağlıklı bağırsak mikrobiyotasının gelişimini engellemesi sonucunda bütirat dâhil olmak üzere KZYA'ların üretimini azaltmaktadır.…”