Relationship between CNS and Immunology: Correlation with Psychology

Ashraf, Ghulam Md; Azhar, Asim; Zia, Qamar; Ali, Ashraf; Rehan, Mohd; Owais, Mohammad; Alexiou, Athanasios; Rauf, Ahmar; Ganash, Magdah; Kamal, Mohammad Amjad; Rajeh, Nisreen

doi:10.2174/1389200219666180129142534

Cited by 6 publications

(4 citation statements)

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“…The strategies the patients employ to cope with the disease are important for adapting to this situation (Spendelow, Eli Joubert, Lee, & Fairhurst, 2018), and influence the health-related quality of life, including in particular the mental condition and mood (Cheng et al, 2012;Nipp et al, 2017), and thus the effect on the immune system, which influences the healing process (cf. Ashraf et al, 2018;D'Acquisto, 2017).…”

Section: Introductionmentioning

confidence: 99%

Personal resources and flexibility in coping with stress depending on perceived stress in a group of cancer patients

Basińska¹,

Sołtys²

2020

Health Psychology Report

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health psychology report • volume 8(2),  original article background Cancer is a highly stressful life event. It requires the employment of new coping skills and strategies. Flexibility in coping with stress plays an important role in this case. The aim of the study was to assess the role of personal resources in shaping the flexibility in coping with stress among cancer patients depending on the level of perceived stress. participants and procedure One hundred eight patients suffering from cancer were surveyed. The following methods were employed: the Resiliency Measurement Scale by Ogińska-Bulik and Juczyński, the Adult Hope Scale by Snyder, the Spirituality Index of Well-Being by Daaleman and Frey, the Flexibility in Coping with Stress Questionnaire by Basińska and team and the Global Measure of Perceived Stress by Cohen, Kamarck and Mermelstein. results The results demonstrated a positive correlation between all considered personal resources and flexibility in coping. Both resiliency and spiritual well-being enable one to predict 23% of variability of flexibility in coping. Cluster analysis revealed that the group of patients with a generally higher level of personal resources was characterised by greater flexibility in all its dimensions. However, stress levels did not modify the relationships between personal resources and flexibility in coping. conclusions The results encourage the planning of psychological interventions aimed at the development of personal resources among cancer patients, and warrant further research.

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Section: Introductionmentioning

confidence: 99%

Personal resources and flexibility in coping with stress depending on perceived stress in a group of cancer patients

Basińska¹,

Sołtys²

2020

Health Psychology Report

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“…Furthermore, the nature of clients is too sensitive in this sector as patients and their attendants feel stressed and any poor dealing can further intensify the issue, which may induce them to misbehave with the staff and create disturbance for all. Stress can negatively affect the health of healthcare professionals and the quality of care for patients (Ashraf et al, 2018). Consistently providing high-quality care is the backbone of an efficient healthcare system.…”

Section: Literature Reviewmentioning

confidence: 99%

Mediating Mechanism of Burnout in the Effect of Stress on Turnover Intention and Service Quality of Employees

Shakil

2023

JDSS

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This study was conducted to examine the effect of stress on turnover intention and service quality of employees. The study further probed the mediating role of burnout in the hypothesized effects. The researchers took a sample of nursing and administrative staff from AJ&K. The study applied a dyadic approach and collected time lagged data to avoid common method biases. Data of stress, burnout and turnover intention were collected from health workers while of service quality from patients and attendants. For analysis, the study used AMOS and SPSS. The hypothesized direct effects were checked by applying SEM. PROCESS macro of Hayes ( 2013) was then applied for probing the mediating mechanism. The results show a positive (negative) effect of stress on turnover intention (service quality) of the employees. This effect was mediated by burnout. The study suggested interventions to manage the issue of stress for better service quality and retention of employees.

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“…There is a growing evidence that innate immune plays an important role in AD’s etiology, although the central nervous system (CNS) has long been considered an immune-privileged site ( Guillot-Sestier and Town, 2013 ; Webers et al, 2020 ). Furthermore, the new insights on the pathogenesis and therapy of AD also indicated the adaptive immune response contributing to the deposition of Aβ in the brain and misfolded tau proteins ( Ashraf et al, 2018 ; Uddin et al, 2020b ), which might open new perspectives in the treatments for AD with active and passive anti-Aβ immunotherapies clearing brain Aβ deposits ( Ciccocioppo et al, 2020 ). Recently, anti-Aβ monoclonal antibodies (mabs) as the immune therapeutic approaches have been investigated as a treatment for AD, including aducanumab, bapineuzumab, gantenerumab, solanezumab, and lecanemab.…”

Section: Introductionmentioning

confidence: 99%

Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer’s Disease: A Focus on Aducanumab and Lecanemab

Shi

Chu

Zhu

et al. 2022

Front. Aging Neurosci.

151

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Alzheimer’s disease (AD) is the most prevalent form of age-related dementia in the world, and its main pathological features consist of amyloid-β (Aβ) plaque deposits and neurofibrillary tangles formed by hyperphosphorylated tau protein. So far, only a few AD treatments approved have been applied in the clinic, but the effects of these drugs are limited only for partial symptomatic relief to patients with AD and are unable to alter AD progression. Later, all efforts for AD treatments with targeting the pathogenic factors were unsuccessful over the past decades, which suggested that the pathogenesis of AD is complex. Recently, disease-modifying therapies (DMTs) that can change the underlying pathophysiology of AD, with anti-Aβ monoclonal antibodies (mabs) (e.g., aducanumab, bapineuzumab, gantenerumab, solanezumab, and lecanemab) have been developed successively and conducted in clinical trials based on the theory that a systemic failure of cell-mediated Aβ clearance contributes to AD occurrence and progression. In the review, we summarized recent studies on the therapeutic effects and clinical trial results of these mabs in patients with AD. Specifically, we focused on the discussion of the impact of aducanumab and lecanemab on AD pathology and clinical profiles. The review provides a possible evidence for applying immunotherapy with anti-Aβ mabs in AD and analyzes lessons learned from these clinical trials in order to further study the therapeutic and adverse effects of these anti-Aβ mabs on AD.

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Relationship between CNS and Immunology: Correlation with Psychology

Abstract: Our manuscript concludes a close relationship between emotion and psychology to diseases and immunology, proclaiming the need of providing enhanced attention on mechanistic aspect of psychoneuroimmunological disorders.

Cited by 6 publications

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Personal resources and flexibility in coping with stress depending on perceived stress in a group of cancer patients

Personal resources and flexibility in coping with stress depending on perceived stress in a group of cancer patients

Mediating Mechanism of Burnout in the Effect of Stress on Turnover Intention and Service Quality of Employees

Impact of Anti-amyloid-β Monoclonal Antibodies on the Pathology and Clinical Profile of Alzheimer’s Disease: A Focus on Aducanumab and Lecanemab

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