Relationship between changes in platelet reactivity and changes in platelet receptor expression induced by physical exercise

Aurigemma, Cristina; Fattorossi, Andrea; Sestito, Alfonso; Sgueglia, Gregory A.; Farnetti, Sara; Buzzonetti, Alexia; Infusino, Fabio; Landolfi, Raffaele; Scambia, Giovanni; Crea, Filippo; Lanza, Gaetano Antonio

doi:10.1016/j.thromres.2007.01.009

Cited by 35 publications

(32 citation statements)

References 22 publications

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“…Accordingly, in several recent studies we have consistently shown decreased closure time with exercise using the PFA-100 method,11 12 18 19 which correlated with an increased expression of platelet membrane receptors (CD41 and P-selectin) 12. We also confirm these findings in the present study, in which we show an increased exercise-induced formation of MPA, which has also been suggested to be a sensitive marker of platelet activation29 and to predict coronary events in CAD patients 30…”

Section: Discussionmentioning

confidence: 75%

Brief low-workload myocardial ischaemia induces protection against exercise-related increase of platelet reactivity in patients with coronary artery disease

Scalone

Coviello

Barone

et al. 2009

Heart

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Section: Discussionmentioning

confidence: 75%

Brief low-workload myocardial ischaemia induces protection against exercise-related increase of platelet reactivity in patients with coronary artery disease

Scalone

Coviello

Barone

et al. 2009

Heart

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“…Moderate alcohol consumption, regular exercise and certain types of nutritional supplements such as omega-3 fatty acids and herbs such as garlic may decrease platelet reactivity [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Gender differences in platelet aggregation in healthy individuals

Otahbachi

Simoni

et al. 2009

J Thromb Thrombolysis

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This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22-36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5'-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen (P < 0.01). Among the ethnic groups, Caucasian women were most prone to platelet aggregation. Gender is a determinant of agonist effects on platelet aggregability in healthy subjects.

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“…In most studies a significant increase in reactivity is reported. Some studies show that platelet reactivity increases with exercise in patients with clinically stable coronary artery disease whereas there are no significant changes in controls [1,4,5].…”

Section: Discussionmentioning

confidence: 99%

“…However, after heavy exercise the levels of these 3 agents increases [1,5]. Intense exercise promotes shear stress and can induce platelet aggregation possibly by enhancing the activity of vWF, which is not, or little, changed by the usual coronary artery disease treatments.…”

Section: Discussionmentioning

confidence: 99%

Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications

Ormezzano

Polack

Vanzetto

et al. 2009

J Thromb Thrombolysis

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Exercise may induce platelet activation in spite of using antiplatelet treatment. We present a case where the initial acute coronary syndrome and the iterative stent thrombosis always occurred after intense and prolonged physical effort. For this patient the at rest response to platelet inhibition with antiplatelet treatments was assessed as adequate, but after exercise the patient developed platelet activation which could be the trigger of his stent thrombosis.

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Relationship between changes in platelet reactivity and changes in platelet receptor expression induced by physical exercise

Cited by 35 publications

References 22 publications

Brief low-workload myocardial ischaemia induces protection against exercise-related increase of platelet reactivity in patients with coronary artery disease

Brief low-workload myocardial ischaemia induces protection against exercise-related increase of platelet reactivity in patients with coronary artery disease

Gender differences in platelet aggregation in healthy individuals

Platelet hyperactivity during exercise leading to iterative coronary stent thrombosis: clinical implications

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