Relationship Between CHA2DS2-VASc Score and Right Ventricular Dysfunction in Patients With Acute Pulmonary Thromboembolism

Gök, Murat; Kurtul, Alparslan; Harman, Murat; Kara, Meryem; Süleymanoğlu, Muhammed; Örnek, Ender

doi:10.1177/1076029618785771

Cited by 8 publications

(15 citation statements)

References 27 publications

(29 reference statements)

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“…Age is an obvious risk factor for patients with CAD and AF (31,33), and elderly individuals are more likely to have coexisting CAD and AF, thus the risk of death in elderly patients with CAD and AF is higher. In addition to the assessment of thromboembolic risk in patients with AF, the CHA 2 DS 2 -VASc score has been shown to predict the adverse outcomes for other cardiovascular conditions, such as chest pain (25), ACS (21,22), AMI (24), HF (20), pulmonary emboli (23), and ACS undergoing percutaneous coronary intervention (PCI) (26). Therefore, we believe that the CHA 2 DS 2 -VASc score is a feasible predictor of prognosis in elderly patients with CAD and AF.…”

Section: Discussionmentioning

confidence: 99%

“…The CHA 2 DS 2 -VASc score [congestive heart failure, hypertension, age ≥75 years (doubled), diabetes, stroke/transient ischemic attack/thromboembolism (doubled), vascular disease (prior myocardial infarction, peripheral artery disease, or aortic plaque), age 65-74 years, sex category (female)] has been used for the assessment of thromboembolic (TE) risk and the guidance of antithrombotic treatment in patients with AF (20). In addition, this simple and well-established scoring system has been shown to predict the risk for other conditions beyond its original designations (20)(21)(22)(23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the CHA2DS2-VASc Score for the Prediction of Death in Elderly Patients With Coronary Artery Disease and Atrial Fibrillation

Wang

Dong

et al. 2021

Front. Cardiovasc. Med.

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Purpose: Coronary artery disease (CAD) and atrial fibrillation (AF) often coexist and lead to a much higher risk of mortality in the elderly population. The aim of this study was to investigate whether the CHA2DS2-VASc score could predict the risk of death in elderly patients with CAD and AF.Methods: Hospitalized patients aged ≥65 years with a diagnosis of CAD and AF were recruited consecutively. Patients were divided into 5 groups according to the CHA2DS2-VASc score (≤2, =3, =4, =5, and ≥6). At least a 1-year follow-up was carried out for the assessment of all-cause death.Results: A total of 1,579 eligible patients were recruited, with 582 all-cause deaths (6.86 per 100 patient-years) occurring during a follow-up of at least 1 year. With the increase in the CHA2DS2-VASc score, the 1-year and 5-year survival rate decreased (96.4% vs. 95.7% vs. 94.0% vs. 86.5% vs. 85.7%, respectively, P < 0.001; 78.4% vs. 68.9% vs. 64.6% vs. 55.5% vs. 50.0%, respectively, P < 0.001). Compared with the patients with CHA2DS2-VASc score <5, for patients with CHA2DS2-VASc score ≥5, the adjusted hazard ratio for death was 1.78 (95% CI: 1.45–2.18, P < 0.001). The predictive values of the CHA2DS2-VASc score ≥5 for in-hospital (C-index = 0.66, 95% CI: 0.62–0.69, P < 0.001), 1-year (C-index = 0.65, 95% CI: 0.63–0.67, P < 0.001) and 5-year (C-index = 0.60, 95% CI: 0.59–0.61, P < 0.001) death were in comparable.Conclusion: In elderly patients with concomitant CAD and AF, the CHA2DS2-VASc score can be used to predict death with moderate accuracy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of the CHA2DS2-VASc Score for the Prediction of Death in Elderly Patients With Coronary Artery Disease and Atrial Fibrillation

Wang

Dong

et al. 2021

Front. Cardiovasc. Med.

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“…In spite of the advances in medical therapies, APE is still a major cause of morbidity and mortality worldwide. Previously, several studies revealed that patient-related clinical factors-such as advanced age and hypotension 2,14 or other some laboratory biomarkers-such as brain-type natriuretic peptide, creatinine kinase-myocardial band and high sensitive troponin I, etc-were found to be useful for the prediction of early mortality in patients with APE. 5,6 The plasma osmolality is a combination of sodium, plasma glucose and BUN.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of plasma osmolality for in‐hospital mortality in patients with acute pulmonary embolism

Öztaş¹,

Çınar²,

Hayıroğlu³

et al. 2019

Clinical Respiratory J

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Introduction and Objectives Prior studies demonstrated that plasma osmolality may have a predictive value for in‐hospital mortality in patients with heart failure and acute coronary syndrome. In addition, plasma glucose and blood urea nitrogen (BUN) levels, the components of plasma osmolality, have been shown to be an important contributor for in‐hospital mortality in acute pulmonary embolism (APE) patients. Hence, the objective of the current study is to evaluate the effect of plasma osmolality upon admission with in‐hospital mortality in patients with APE. Methods A total of 245 consecutive intermediate or high risk APE patients were enrolled into the study. The study population was divided into three tertile groups (T1, T2 and T3) based on the increased plasma osmolality. The in‐hospital mortality was the primary end‐point. Results After adjusting for all risk factors, in‐hospital mortality was significantly higher in the T3 group compared to T1 and T2 groups (OR: 3.6, 95% CI: 1.3 to 18.8, P < .001). In addition, the incidence of asystolia, hypotension and cardiogenic shock were significantly higher in the T3 group. An area under the receiver operating characteristic curve value of plasma osmolality for the in‐hospital mortality was 0.76 with sensitivity 67.2% and specificity 74.1% 95% CI: (0.66‐0.87, P < .001). Conclusion This is the first study to demonstrate that elevated levels of plasma osmolality may have a predictive value for in‐hospital mortality in APE patients. Our findings are novel and deserve further studies whether the treatment of higher plasma osmolality may reduce the risk of in‐hospital mortality in APE patients.

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“…The components of these two scores are associated with atherosclerosis, vascular spasm, and microvascular dysfunction, which overlap the risk factors of NRP [7]. Several recent studies have also shown that the CHA 2 DS 2 -VASc scores are associated with the severity of coronary artery disease, its prognosis, and NRP in patients with acute MI, contrast-induced nephropathy after PPCI for acute coronary syndrome, in-stent restenosis, acute stent thrombosis, mechanical mitral valve thrombosis, and right ventricular dysfunction [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 96%

New CHA2DS2-VASc-HSF score predicts the no-reflow phenomenon after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

Zhang

Sun

2020

BMC Cardiovasc Disord

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Background: The no-reflow phenomenon (NRP) is a serious complication of primary percutaneous coronary intervention (PPCI) and is an independent predictor of poor prognosis. We aimed to find a simple but effective risk stratification method for the prediction of NRP. Methods: This retrospective single-center study included 454 consecutive patients diagnosed with acute STsegment elevation myocardial infarction (STEMI) and treated by PPCI, who were admitted to our emergency department between January 2017 and March 2019. The patients were divided according to the post-PPCI thrombolysis in the myocardial infarction flow rate: the NRP group and the control group. The CHADS 2 , CHA 2 DS 2-VASc, and CHA 2 DS 2-VASc-HSF scores were calculated for all the patients in this study, and multivariable regression and receiver operating characteristic curve analyses were conducted to determine the independent predictors of NRP and the predictive value of the three scores. Results: A total of 454 patients were analyzed in this study: 80 in the no-reflow group and 374 in the control group. The incidence of NRP was 17.6%. Creatine kinase-myocardial band, Killip class, stent length, and multivessel disease also independently predicted NRP. The CHA 2 DS 2-VASc-HSF score had a higher predictive value than the other two scores, and a CHA 2 DS 2-VASc-HSF score of ≥4 predicted NRP with a sensitivity of 72.5% and specificity of 66.5% (area under the curve: 0.755, 95% confidence interval [0.702-0.808]). Conclusion: Although the CHADS 2 , CHA 2 DS 2-VASc, and CHA 2 DS 2-VASc-HSF scores can all be used as simple tools to predict NRP, our findings show that the CHA 2 DS 2-VASc-HSF score had the highest predictive value. Thus, the CHA 2 DS 2-VASc-HSF score may be an optimal tool for predicting high-risk patients.

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Relationship Between CHA2DS2-VASc Score and Right Ventricular Dysfunction in Patients With Acute Pulmonary Thromboembolism

Cited by 8 publications

References 27 publications

Assessment of the CHA2DS2-VASc Score for the Prediction of Death in Elderly Patients With Coronary Artery Disease and Atrial Fibrillation

Assessment of the CHA2DS2-VASc Score for the Prediction of Death in Elderly Patients With Coronary Artery Disease and Atrial Fibrillation

The predictive value of plasma osmolality for in‐hospital mortality in patients with acute pulmonary embolism

New CHA2DS2-VASc-HSF score predicts the no-reflow phenomenon after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction

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