Relationship Between Cerebral Vascularity and P32 Uptake

Mechanisms of postischemic brain edema: contribution of circulatory factors.

“…But at the same time the conditions of the present experiments did not allow study of ischemic cerebral edema which could develop in the regions remaining continuously ischemic, or edema reaching a maximum several hours or even days after the onset of ischemia. 6 ' '• 20 The present studies showed that brain edema does not develop during cerebral ischemia lasting 15 minutes and appears only in the postischemic period when the brain becomes hyperemic. However, the pre-edematous changes in the brain tissue which are crucial for the development of edema appear certainly during ischemia.…”

“…6 ' 7 Under local anesthesia (1% lidocaine), the crystal-tipped catheter was introduced into a brachial arterial incision and advanced to the origin of the right carotid artery. In addition, a standard fluid-filled catheter connected to a Statham P23Db strain gauge was advanced from a medial antecubital vein to the right heart for the purpose of obtaining right atrial pressures.…”

“…5 Blood-brain barrier permeability is increased during hypoxic-ischemic conditions, 6 but its changes are not parallel with the development of postischemic brain edema. 7 ' 8 It is obvious that the disturbance of water exchange between blood and cerebral tissue during postischemic edema development should be largely dependent on the circulatory parameters.…”

Mechanisms of postischemic brain edema: contribution of circulatory factors.

“…But at the same time the conditions of the present experiments did not allow study of ischemic cerebral edema which could develop in the regions remaining continuously ischemic, or edema reaching a maximum several hours or even days after the onset of ischemia. 6 ' '• 20 The present studies showed that brain edema does not develop during cerebral ischemia lasting 15 minutes and appears only in the postischemic period when the brain becomes hyperemic. However, the pre-edematous changes in the brain tissue which are crucial for the development of edema appear certainly during ischemia.…”

“…6 ' 7 Under local anesthesia (1% lidocaine), the crystal-tipped catheter was introduced into a brachial arterial incision and advanced to the origin of the right carotid artery. In addition, a standard fluid-filled catheter connected to a Statham P23Db strain gauge was advanced from a medial antecubital vein to the right heart for the purpose of obtaining right atrial pressures.…”

“…5 Blood-brain barrier permeability is increased during hypoxic-ischemic conditions, 6 but its changes are not parallel with the development of postischemic brain edema. 7 ' 8 It is obvious that the disturbance of water exchange between blood and cerebral tissue during postischemic edema development should be largely dependent on the circulatory parameters.…”

Mechanisms of postischemic brain edema: contribution of circulatory factors.

“…But at the same time the conditions of the present experiments did not allow study of ischemic cerebral edema which could develop in the regions remaining continuously ischemic, or edema reaching a maximum several hours or even days after the onset of ischemia. 6 ' '• 20 The present studies showed that brain edema does not develop during cerebral ischemia lasting 15 minutes and appears only in the postischemic period when the brain becomes hyperemic. However, the pre-edematous changes in the brain tissue which are crucial for the development of edema appear certainly during ischemia.…”

“…6 ' 7 Under local anesthesia (1% lidocaine), the crystal-tipped catheter was introduced into a brachial arterial incision and advanced to the origin of the right carotid artery. In addition, a standard fluid-filled catheter connected to a Statham P23Db strain gauge was advanced from a medial antecubital vein to the right heart for the purpose of obtaining right atrial pressures.…”

“…5 Blood-brain barrier permeability is increased during hypoxic-ischemic conditions, 6 but its changes are not parallel with the development of postischemic brain edema. 7 ' 8 It is obvious that the disturbance of water exchange between blood and cerebral tissue during postischemic edema development should be largely dependent on the circulatory parameters.…”

Mechanisms of postischemic brain edema: contribution of circulatory factors.

“…But at the same time the conditions of the present experiments did not allow study of ischemic cerebral edema which could develop in the regions remaining continuously ischemic, or edema reaching a maximum several hours or even days after the onset of ischemia. 6 ' '• 20 The present studies showed that brain edema does not develop during cerebral ischemia lasting 15 minutes and appears only in the postischemic period when the brain becomes hyperemic. However, the pre-edematous changes in the brain tissue which are crucial for the development of edema appear certainly during ischemia.…”

“…6 ' 7 Under local anesthesia (1% lidocaine), the crystal-tipped catheter was introduced into a brachial arterial incision and advanced to the origin of the right carotid artery. In addition, a standard fluid-filled catheter connected to a Statham P23Db strain gauge was advanced from a medial antecubital vein to the right heart for the purpose of obtaining right atrial pressures.…”

“…5 Blood-brain barrier permeability is increased during hypoxic-ischemic conditions, 6 but its changes are not parallel with the development of postischemic brain edema. 7 ' 8 It is obvious that the disturbance of water exchange between blood and cerebral tissue during postischemic edema development should be largely dependent on the circulatory parameters.…”