Relationship between brachial flow-mediated dilation and carotid intima-media thickness in patients with coronary artery disease

Toyoda, Shigeru; Tokoi, Seiko; Takekawa, Hidehiro; Matsumoto, Hisae; Inami, Shu; Sakuma, Masashi; Arikawa, Takuo; Abe, Shichiro; Nakajima, Toshiaki; Hirata, Koichi; Inoue, Teruo

doi:10.23736/s0392-9590.20.04315-1

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…In this study, FMD <5% was used as a cutoff value to distinguish whether there was endothelial dysfunction. FMD values defining vascular endothelial dysfunction have been reported differently in different studies, ranging from 3.7%-11.3% (22)(23)(24)(25)(26)(27)(28)(29). However, in clinical work, 5% (28) and 6% (29) are considered to be more appropriate cutoff values for people with potential endothelial dysfunction and are also the most widely used in screening large samples of people.…”

Section: Discussionmentioning

confidence: 99%

Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China

Yang

et al. 2023

Front. Cardiovasc. Med.

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Sedentary behavior is a risk factor for several diseases, and previous studies have mostly reported the effects of acute sedentary behavior on vascular endothelial function. Data on the relationship between sedentary lifestyle habits and vascular function in large sample populations are lacking. Therefore, the aim of this study was to assess the correlation between self-reported sedentary behavior and peripheral vascular function in a check-up population from real-world data.MethodsWe recruited 13,220 participants from two health management centers of general tertiary hospitals located in northern and southern China between 2017 and 2021. All participants had undergone both questionnaires and brachial artery flow-mediated dilation (FMD) measurements.ResultsIn total, 3,205 participants with FMD ≤ 5.0% were identified to have endothelial dysfunction. In a multivariable regression model including lifestyle habits such as sedentary behavior and cardiovascular risk factors, taking leisure sedentary time <2 h/day as a reference, the risk of vascular endothelial dysfunction gradually increased with time: 2–4 h/day (OR = 1.182, 95% CI: 1.058–1.321, P = 0.003), 4–6 h/day (OR = 1.248, 95% CI: 1.100–1.414, P = 0.001) and >6 h/day (OR = 1.618, 95% CI: 1.403–1.866, P < 0.001).ConclusionLonger leisure sedentary time is associated with a higher prevalence of vascular endothelial dysfunction. These findings suggest that leisure sedentary behavior is a risk factor for the occurrence of vascular endothelial dysfunction in the Chinese check-up population.

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Section: Discussionmentioning

confidence: 99%

Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China

Yang

et al. 2023

Front. Cardiovasc. Med.

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“…Например, в небольших клинических работах (50-150 человек) у больных ишемической болезнью сердца (ИБС) [4] и при сочетании ИБС с сахарным диабетом 2 типа [5] показана обратная связь ПЗВД с ТИМК сонных или бедренных артерий. В другом исследовании среди больных с ИБС достоверной связи ПЗВД с ТИМК не выявлено [6]. В группе 75 больных с мозговым инсультом выявлена обратная связь ПЗВД с наличием каротидных атеросклеротических бляшек и сте пенью стеноза [7].…”

Section: Relationships and Activitiesunclassified

“…В недавней работе Toyoda S, et al (2020) была отмечена тенденция к связи между изучаемыми показателями: r=-0,149, p=0,061 [6]. В выборку во шли лица с подтвержденной ишемической болезнью сердца (n=159 человек), средний возраст пациентов составил 67±8 лет, был ближе к нашему возрастному диапазону, для которого мы показали, что у женщин младше 78 лет наличие ЭД ассоциировалось с увеличением ТИМК.…”

Section: заключениеunclassified

Endothelial function and structural markers of atherosclerosis: relationship in old and senile age

et al. 2021

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Endothelial dysfunction (ED), intima-media thickness (IMT), and atherosclerotic plaques (ASPs) of the carotid arteries (CAs) are considered mutually associated markers of subclinical and clinical atherosclerosis. How true this statement is for older age groups remains unclear.Aim. To study the relationship of flow-dependent vasodilation (FDV) with CA IMT and ASPs in a population sample over 58 years old.Material and methods. The study was carried out in a population sample of men and women aged 58-82 years (Novosibirsk, HAPIEE project, n=788, 424 women). CA ultrasound was performed to assess IMT and ASPs. Endothelial function was assessed by postocclusive hyperemia ultrasound test; an increase in brachial artery initial diameter (FDV%) <10% was regarded as ED.Results. The average IMT in men was 0,95 mm (SD 0,18) and was significantly higher than in women: 0,88 mm (SD 0,17), p<0,001. The average FDV% values in men were 2,7% (SD 7,32), while in women — 3,2% (SD 7,19) and did not differ significantly by sex. The incidence of ED was 88,2% in men and 85,8% in women. There was no a significant linear relationship between FDV and IMT neither in men (β=-1,76, SD 2,25, p=0,436), nor in women (β=-2,19, SD 2,15, p=0,309). Also, there were no differences in average IMT and ASP frequency in the groups with and without ED among men and women. When divided into age groups, ED was associated with an increase in IMT only in women aged <78 versus women without ED (p=0,047).Conclusion. In the population sample of 58-82 years old, mutual associations of subclinical markers of atherosclerosis (ED, IMT, ASP of CAs) have not been confirmed. Only in women aged <78 years, ED was associated with an increase in IMT. The results obtained indicate that the treatment approaches proposed for young and middle-aged people may be less effective in old and senile age.

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Relationship between brachial flow-mediated dilation and carotid intima-media thickness in patients with coronary artery disease

Cited by 2 publications

References 36 publications

Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China

Relationship between sedentary behavior and endothelial dysfunction in a cross-sectional study in China

Endothelial function and structural markers of atherosclerosis: relationship in old and senile age

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