Relations of Epicardial Adipose Tissue Measured by Multidetector Computed Tomography to Components of the Metabolic Syndrome Are Region-Specific and Independent of Anthropometric Indexes and Intraabdominal Visceral Fat

Wang, Tzung‐Dau; Lee, Wei-Jei; Shih, Fuh‐Yuan; Huang, Chien‐Hua; Chang, Yeun‐Chung; Chen, Wen‐Jone; Lee, Yuan‐Teh; Chen, Ming-Fong

doi:10.1210/jc.2008-0834

Cited by 120 publications

(114 citation statements)

References 29 publications

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“…In agreement with previous autopsy studies, or studies using Cardiac adiposity and heart function in obesity B Gaborit et al echography or computed tomography, EFV increases with age, BMI and waist circumference. 15,16,37,42 Surprisingly, EFV was not correlated with LV mass or EDV. Previous studies showed similar results.…”

Section: Discussionmentioning

confidence: 90%

“…The relative importance of VAT or EFV in the prediction of metabolic syndrome is a matter of debate. 16,31 Computed tomography measurement of EF thickness in the left atrioventricular groove was proposed as a more accurate assessment of metabolic risk than VAT. 16 A recent study by Iozzo et al 31 in 53 subjects, separated according to glucose tolerance, reported that pericardial fat and myocardial fat were independently related to plasma glucose levels, but the authors did not account for VAT.…”

Section: Discussionmentioning

confidence: 99%

“…16,31 Computed tomography measurement of EF thickness in the left atrioventricular groove was proposed as a more accurate assessment of metabolic risk than VAT. 16 A recent study by Iozzo et al 31 in 53 subjects, separated according to glucose tolerance, reported that pericardial fat and myocardial fat were independently related to plasma glucose levels, but the authors did not account for VAT. Here, it is clearly shown that the link between EFV, MTGC and markers of metabolic risk was dependent on the amount of VAT, as these correlations did not remain significant after adjustment for VAT.…”

Section: Discussionmentioning

confidence: 99%

“…8,9 It has been shown that this ectopic fat is associated with the development of atherosclerotic coronary artery disease. [8][9][10][11][12][13][14][15][16] Its anatomic location, without any barrier to the adjacent myocardium, enables local paracrine interaction between EF and the myocardium, suggesting that EF could also have a functional and mechanical role in obesity-related dilated cardiomyopathy. 17,18 Myocardial lipid deposition (that is, lipid accumulation in the myocyte cytoplasm) is also a marker of ectopic fat accumulation.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

et al. 2011

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Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Research design and methods: Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m À2 ) and 30 obese (BMI: 41.8 ± 6 kg m À2 ) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. Results: EFV and MTGC were positively correlated (r ¼ 0.52, Po0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141±18 versus 79±7 ml, P ¼ 0.0001; 1.0±0.1 versus 0.6±0.1%, P ¼ 0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213±34 versus 141±18 ml, P ¼ 0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (Po0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (b ¼ À0.38, P ¼ 0.01), suggesting an impact of cardiac steatosis in cardiac function. Conclusions: These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

et al. 2011

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“…13 Many studies have concluded that EAT is higher in the patients with diabetics, HT and obesity. [6][7][8][21][22][23] DM and HT are closely related with the metabolic syndrome and the two most frequently observed reasons of the increased cardiovascular risk in the general population and the ESRF patients. No study has been recorded yet which addresses uremic factors and its relationship with EAT in the dialysis patients without DM and HT.…”

Section: Discussionmentioning

confidence: 99%

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

2013

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Turkey AbstractPurpose: It has been found out that the epicardial adipose tissue (EAT) measured by echocardiography is related with various metabolic parameters. Being accepted as the new cardiovascular risk indicator, there have been few studies on EAT in relation to the patients with end-stage renal failure. In our study, we aim to evaluate EAT and carotid intima media thickness (CIMT) in non-diabetic, non-hypertensive hemodialysis (HD) patients. Methods: Our study recruited 47 non-diabetic, non-hypertensive HD patients (22 males, 25 females, median age 54 (44.3-60.8) years) and an age-gender matched control group consisting 41 healthy subjects (17 males, 24 females, median age 52 (48-56) years). In all patients, EAT was measured by echocardiography and CIMT by ultrasonography; and routine laboratory parameters were studied. Results: In our study, we obtained laboratory findings matching with the profiles of uremic patients among HD patients and CIMT values of HD patients are significantly higher than that of the control group

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Association of Epicardial Adipose Tissue With Cardiometabolic Risk and Metabolic Syndrome in Patients With Rheumatoid Arthritis

Ormseth

Lipson

Alexopoulos

et al. 2013

Arthritis Care & Research

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Objective Patients with rheumatoid arthritis (RA) have increased coronary atherosclerosis possibly related to increased prevalence of visceral adiposity, insulin resistance, and metabolic syndrome. Epicardial adipose tissue (EAT), a type of visceral fat, may contribute to cardiometabolic risk. The aim of this study was to measure EAT volume in patients with RA and determine its relationship with cardiometabolic risk markers and coronary artery calcium. Methods EAT volume and coronary artery calcium score were measured by non-contrast cardiac computed tomography and compared in RA patients (n=162) and controls (N=89). The relationships between EAT volume and markers of cardiometabolic risk in RA were examined with adjustment for age, race and sex. Results Among RA patients, EAT volume was positively associated with IL-6 (P=0.03), triglycerides (P=0.004), hypertension (P=0.01), homeostatic model of insulin resistance (HOMA) (P<0.001), smoking history (P=0.04), and homocysteine (P=0.001) and negatively associated with HDL (P=0.005). With further adjustment for waist circumference (a measure of visceral obesity), EAT remained independently associated with triglycerides, HOMA, current smoking and homocysteine (all P<0.05). EAT volume was not associated with corticosteroid use or coronary artery calcium score. Patients with metabolic syndrome had significantly greater EAT volume (P<0.001) and each increase in metabolic syndrome criteria was associated, on average, with a 20% increase (95% CI, 14–26%) in EAT volume (P<0.001). Conclusion EAT volume is associated with metabolic syndrome and cardiometabolic risk factors including insulin resistance, triglycerides, current smoking, and homocysteine levels, but not with coronary artery calcium in RA patients.

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Relations of Epicardial Adipose Tissue Measured by Multidetector Computed Tomography to Components of the Metabolic Syndrome Are Region-Specific and Independent of Anthropometric Indexes and Intraabdominal Visceral Fat

Abstract: A simple measurement of EAT thickness in the left atrioventricular groove may provide a more accurate assessment of metabolic risk associated with EAT, which could not be accounted for by anthropometric indexes and intraabdominal visceral fat.

Cited by 120 publications

References 29 publications

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat

Echocardiographic evaluation of epicardial adipose tissue in non-diabetic, non-hypertensive hemodialysis patients

Association of Epicardial Adipose Tissue With Cardiometabolic Risk and Metabolic Syndrome in Patients With Rheumatoid Arthritis

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