Relation of Serum and Semen Malondialdehyde and Total Anti-Oxidants with Sperm Parameters in Infertile Men

Akbari-Asbagh,

doi:10.3844/ajisp.2010.43.49

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…Several studies have shown that lipid peroxidation impacts the sperm concentration, motility, morphology and associated with poor sperm quality ( 40 - 42 ) Patel et al observed ( 43 ) the negative correlation between the MDA levels and the normal sperm motility and morphology, so they suggested damaging effect of free radicals on sperm membrane integrity. Asbagh et al ( 44 ) showed that there was significant association between semen MDA and abnormal sperm morphology, and decrease semen TAC and weak sperm motility. Gholinezhad and Hosseinzadeh Colagar6 showed a negative correlation between MDA levels and the motility and morphology of spermatozoa and a positive correlation between the TAC reflected by motility and morphology of spermatozoa in asthenoteratospermic smokers and non-smokers in comparison with a control group.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Sperm Parameters With Semen Lipid Peroxidation and Total Antioxidants Levels in Astheno- and Oligoasheno- Teratospermic Men

Colagar¹,

Karimi²,

Jorsaraei³

2013

Iran Red Crescent Med J

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Background: Sperm dysfunction caused by reactive oxygen species (ROSs) is one of the major causes of infertility in men, which leads to, lipid peroxidation (LPO) and the formation of stable peroxidation products like Malondialdehyde (MDA) in seminal plasma. MDA is effective factor in reducing fertility. Objectives: The aim of this study is to determine two biochemical markers of oxidative stress; TAC and MDA, and them correlation to quality-quantity factors in Asthenoteratospermic and Oligoashenoteratospermic men. Patients and Methods: A total of 42 semen samples including: 15 samples normospermic as control group, 12 Asthenoteratospermic and 15 oligoasthenoteratospermic were collected from Babol IVF center; Iran. Semen analysis was performed according to WHO (1999) guidelines. Seminal plasma TAC and MDA levels in all patients were measured by TBARs and FRAP methods, respectively. Results: Seminal plasma TAC level in normospermic men was significantly higher than asthenoteratospermic men (P < 0.001) and oligasthenoteratospermic men (P < 0.001) and had posetive correlation with sperm count, motility and morphology. In contrast MDA levels in normospermic men were significantly lower than in asthenoteratospermic men (P = 0.049) and oligoasthenoteratospermic men (P = 0.001) and had negative correlation with sperm count, motility and morphology. Conclusions: These results suggest that lipid peroxidation and decreasing total antioxidant capacity lead to low motility; morphology and sperm count in spermatozoa of astheno-and oligoastheno-teratospermic men. Therefore, evaluation of oxidative status and antioxidant defenses system may be as a useful tool for diagnosis and treatment of male infertility especially in idiopathic male infertility. Keywords: Lipid Peroxidation; Malondialdehyde; Reactive Oxygen SpeciesImplication for health policy/practice/research/medical education: Lipid peroxidation and decreasing total antioxidant capacity lead to low motility, morphology and sperm count in spermatozoa of astheno -and oligoastheno -teratospermic men.

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Section: Discussionmentioning

confidence: 99%

Correlation of Sperm Parameters With Semen Lipid Peroxidation and Total Antioxidants Levels in Astheno- and Oligoasheno- Teratospermic Men

Colagar¹,

Karimi²,

Jorsaraei³

2013

Iran Red Crescent Med J

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“…However, they did not find any association between smoking and sperm parameters in infertile men (25).…”

Section: Discussionmentioning

confidence: 99%

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Fazeli¹,

Salimi²

2016

Avicenna J Med Biochem

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Background: Oxidative stress is the result of an imbalance between the production and scavenging of reactive oxygen species (ROS). Recently, oxidative stress has been introduced as a major cause of male infertility. Objectives: The aim of the present study was to determine the correlation between total antioxidant capacity (TAC) and malondialdehyde (MDA) as markers of oxidative stress in relation to idiopathic male infertility and sperm parameters. Patients and Methods: This case control study was conducted using 35 men with idiopathic infertility and 34 men with proven fertility. Seminal plasma TAC and MDA were measured by ferric reducing ability of plasma (FRAP) and thiobarbituric acid (TBA) reaction methods, respectively. Results: Seminal TAC levels were significantly lower and seminal MDA levels were significantly higher in men with idiopathic infertility than in fertile men (P < 0.0001 and P = 0.004, respectively). A positive correlation was shown between sperm motility, sperm morphology, and TAC levels in men with idiopathic infertility (P = 0.002 and P = 0.002, respectively). In addition, there was a correlation between sperm motility and TAC levels in fertile men (P = 0.005). There was no correlation between sperm count and TAC levels in either men with idiopathic infertility or in fertile men. Negative correlations were observed between MDA levels and sperm motility, morphology, and sperm count only in men with idiopathic infertility (P = 0.003, P = 0.001, and P = 0.006, respectively). Conclusions: Our results show that oxidative stress could play an important role in male infertility as well as in sperm motility and sperm morphology.

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“…Our study result was similar to the studies done by Colagar et al ., Fazeli and Salimi, and Hosen et al ., and Asbagh et al . [10151617] Excessive oxidative stress in the semen of men with abnormal semen parameters was the reason for higher MDA value.…”

Section: Discussionmentioning

confidence: 99%

Role of oxidative stress and antioxidants in male infertility: An interventional study

2019

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Aims:The study aims, in infertile men, (i) to assess oxidative stress parameters in semen plasma and (ii) to study the effect of antioxidants in those with abnormal semen parameters.Settings and Design:This was an interventional study.Population:Ninety men attending and infertility clinic in a tertiary center were enrolled in the study.Materials and Methods:The present study was conducted in the departments of obstetrics and gynecology and biochemistry in a tertiary center. Ethical approval was obtained from the institute ethics subcommittee, and the study was conducted between July 2014 and July 2016. The study was conducted on two groups of 45 men with normal semen parameters in group 1 and 45 men with abnormal semen parameters in group 2.Results:Malondialdehyde (MDA) value was higher in men with abnormal semen parameters, which was statistically significant. The total antioxidant assay was higher in men with abnormal semen parameters, which was not statistically significant. Oxidative stress index (OSI) value was higher in men with normal semen parameters, which was not statistically significant. After 90 days of antioxidants therapy to men with abnormal semen parameters, MDA value decreased, total antioxidant assay increased, and OSI value decreased, which were statistically significant. Semen parameters such as sperm concentration, motility, and normal morphology improved after 90 days of antioxidant therapy, which were statistically significant.Conclusions:Oxidative stress is increased in men with abnormal semen parameters. Antioxidant therapy improves sperm concentration and motility and decreases oxidative stress in the semen plasma.

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Relation of Serum and Semen Malondialdehyde and Total Anti-Oxidants with Sperm Parameters in Infertile Men

Cited by 7 publications

References 36 publications

Correlation of Sperm Parameters With Semen Lipid Peroxidation and Total Antioxidants Levels in Astheno- and Oligoasheno- Teratospermic Men

Correlation of Sperm Parameters With Semen Lipid Peroxidation and Total Antioxidants Levels in Astheno- and Oligoasheno- Teratospermic Men

Correlation of Seminal Plasma Total Antioxidant Capacity and Malondialdehyde Levels With Sperm Parameters in Men With Idiopathic Infertility

Role of oxidative stress and antioxidants in male infertility: An interventional study

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