Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients

Tretjakovs, Pēteris; Jurka, Antra; Bormane, Inga; Mackevics, Vitolds; Miķelsone, Indra; Balode, Liga; Reihmane, Dace; Stukena, Inga; Bahs, Guntis; Aivars, Juris Imants; Pīrāgs, Valdis

doi:10.1016/j.ejim.2009.08.004

Cited by 23 publications

(18 citation statements)

References 52 publications

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“…These data support the findings of other studies showing correlation of high circulating MCP-1 levels in obese individuals [23, 24] and in type 2 diabetes [25]. However, previous studies have shown that serum levels of MCP-1 are decreased after weight loss in obese healthy individuals [24, 25]. Due to the late presentation of pancreatic cancer, many patients may have already lost a considerable amount of weight by the time they have presented for surgical intervention.…”

Section: Discussionsupporting

confidence: 92%

Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

Sullivan

Gong

Hyslop

et al. 2011

Journal of Oncology

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Background/Aims. Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients. Methods. ELISA was used to analyze MCP-1 serum levels in PDA (n = 62) and intraductal papillary mucinous neoplasms (IPMN) (n = 27). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters. Results. Log MCP-1 values were significantly (P < 0.05) elevated in patients with BMI ≥ 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age. Conclusion. MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.

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Section: Discussionsupporting

confidence: 92%

Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

Sullivan

Gong

Hyslop

et al. 2011

Journal of Oncology

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“…However, the precise cellular mechanisms explaining the pathophysiology of adipose tissue and its association with the comorbid conditions of obesity are not entirely understood. It is postulated that a chronic state of low-grade inflammation, created by proinflammatory cytokines and peptides secreted by adipose tissue, mediates the link between obesity and both cardiovascular disease and insulin resistance [12,13]. C-reactive protein (CRP), an acute-phase reactant produced mainly in the liver in response to IL-6, is also a reliable marker of current inflammatory status [13,14].…”

mentioning

confidence: 99%

Early effects of gastric bypass on endothelial function, inflammation, and cardiovascular risk in obese patients

et al. 2011

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“…20 Moreover, hypoadiponectinemia independently correlates with CAD. 21 However, elevated adiponectin levels are associated with an increased risk for cardiovascular events in patients with CAD, 3 though the mechanisms mediating this association are not clear. Increased arterial stiffness as assessed by PWV has an independent prognostic value in patients with CAD.…”

Section: Discussionmentioning

confidence: 99%

Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease

Ikonomidis

Kadoglou

Tsiotra

et al. 2012

American Journal of Hypertension

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Increased mRNA and protein expression of adiponectin receptors is related with increased aortic stiffness, coronary and peripheral atherosclerosis in patients with CAD. The interrelation of AdipoR2 with inflammatory markers, PWV and IMT suggests a compensatory increase of these receptors to counteract the excess inflammatory and atherogenic process in CAD. Thus, adiponectin receptors may provide a potential therapeutic target of agents activating their beneficial action.American Journal of Hypertension 2012; doi:10.1038/ajh.2012.42.

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Relation of inflammatory chemokines to insulin resistance and hypoadiponectinemia in coronary artery disease patients

Cited by 23 publications

References 52 publications

Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

Early effects of gastric bypass on endothelial function, inflammation, and cardiovascular risk in obese patients

Arterial Stiffness Is Associated With Increased Monocyte Expression of Adiponectin Receptor mRNA and Protein in Patients With Coronary Artery Disease

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