Relation of Gender-Specific Risk of Ischemic Stroke in Patients With Atrial Fibrillation to Differences in Warfarin Anticoagulation Control (from AFFIRM)

Sullivan, Renee M.; Zhang, Jingyang; Zamba, Gideon; Lip, Gregory Y.H.; Olshansky, Brian

doi:10.1016/j.amjcard.2012.08.014

Cited by 88 publications

(56 citation statements)

References 13 publications

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“…При этом больные нашего исследова-ния не являются искусственно отобранной ко-гортой, а представляют собой традиционных пациентов врача-кардиолога. При сравнении с данными других исследований и регистров, посвященных рутинной практике [6][7][8][9][10], па-циенты нашей выборки моложе, но в большин-стве своем тяжелее. Их средний возраст соста-вил 64,6 года, число пациентов старше 75 лет -лишь 12%, но при этом средняя сумма баллов по шкале CHA 2 DS 2 -VASc составила 3,2 ± 1,76.…”

Section: Discussionunclassified

“…Несмотря на меньшую частоту инсультов в группе варфарина, продемонстрированную в клинических исследованиях [11][12][13], когорт-ные исследования и регистры, выполненные в реальной клинической практике, демонстри-руют схожую с нашими данными частоту со-бытий при длительном наблюдении [8,10,[15][16][17]. Так, в исследовании [16], включавшем па-циентов с ФП, подвергнутых плановым чре-скожным коронарным вмешательствам, часто-та ИИ составила 2,6% в год, что согласуется с нашими данными.…”

Section: Discussionunclassified

“…Больные высокого риска, имею-щие ≥ 4 баллов по шкале CHA 2 DS 2 -VASc, имели наихудший прогноз по сравнению с другими больными, что согласуется с данными иссле-дований [6,8,16,22]. Ранее нами было показа-но [23], что количество баллов по шкале CHADS 2 ≥ 3 у больных с ФП явилось предикто-ром развития комбинированной конечной то-чки (ИИ/ТИА, сердечно-сосудистая смерть, острый коронарный синдром).…”

Section: Discussionunclassified

See 2 more Smart Citations

THE EFFICACY OF LONG-TERM WARFARIN THERAPY: THE IMPACT ON THE INCIDENCE OF ISCHEMIC CEREBROVASCULAR DISORDERS AND CLINICAL PREDICTORS OF DEVELOPING SUCH DISORDERS. (Results of a prospective 10-year follow-up study)

et al. 2017

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Section: Discussionunclassified

See 1 more Smart Citation

THE EFFICACY OF LONG-TERM WARFARIN THERAPY: THE IMPACT ON THE INCIDENCE OF ISCHEMIC CEREBROVASCULAR DISORDERS AND CLINICAL PREDICTORS OF DEVELOPING SUCH DISORDERS. (Results of a prospective 10-year follow-up study)

et al. 2017

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“…Bu yüzden kadınlarda daha agresif ve yeni tedavilere ihtiyaç duyulduğu belirtilmektedir (5,6). Diğer bir düşünce tarzı ise erkeklere nazaran kadınlarda belki de daha yüksek bir INR düzeyinin gerektiğidir (1,7). Tedaviye daha az uyum, erkeklerde yüksek mortalite nedeniyle hayatta uzun süre kalıp inme geçirememeleri, yaşlı kadın hastaların tek başına yaşamaları nedeniyle hastaneye çok sık başvuramamaları, hormonal ve genetik nedenler gibi sebepler diğer spekülatif durumlar arasında sayılabilir (3,8).…”

Section: Discussionunclassified

Women Sex Importance in Stroke Patients with Atrial Fibrillation

Mısırli¹,

Domaç²,

Özkan³

et al. 2014

Türk Beyin Damar Hast Derg

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ÖZETAMAÇ: Atriyal fibrilasyonlu inme hastalarının kadın ve erkek cinsiyeti, yaş, risk faktörleri ve tedavi açısından farklılık gösterip göstermediğine bakıldı. GEREÇ ve YÖNTEM: Son 2 yıllık sürede kliniğimize yatırılan atriyal fibrilasyonlu iskemik inme hastaları başlıca 75 yaş altı ve üstü 2 gruba ayrılarak CHADS2 ve CHA2DS2VASc skorları ile değerlendirildi ve kadın-erkek cinsiyet farklılıklarına bakıldı. BULGULAR: Cinsiyete göre inme oranları özellikle 75 yaş üstünde kadınlarda istatistiksel olarak anlamlı bulundu. Risk faktörlerine de yaşlı kadınlarda daha fazla rastlandı ve CHA2DS2VASc skorları erkeklerden yüksek olduğundan antikoagülan tedaviye daha çok başlandı. Lone atriyal fibrilasyon cinsiyet farkı göstermedi ve hastalara antikoagülan başlanmadı. SONUÇ: Yetmişbeş yaş üstü atriyal fibrilasyonlu kadınlarda risk faktörleri, inme oranı ve antikoagülan başlama oranı yüksek idi . Anahtar Sözcükler: Atriyal fibrilasyon, stroke, kadın, CHADS2, CHA2DS2VASc, risk faktörleri, yaş. WOMEN SEX IMPORTANCE IN STROKE PATIENTS WITH ATRIAL FIBRILLATION ABSTRACTOBJECTIVE: It was shown the differences in age, risk factors and treatment between women and men in stroke patients with atrial fibrillation. MATERIAL and METHODS: The stroke patients with atrial fibrillation who were hospitalized in our department at the last 2 years were seperated into 2 groups of aged above 75 and below 75, investigated with CHADS2 and CHA2DS2VASc scores and looked at the sex differences of women and men. RESULTS: Stroke ratio according to sex was statistically meaningful especially in women above the age of 75. Risc factors also were founded in elderly women and CHA2DS2VASc scores were higher in women than men so more anticoagulan treatment were begun. No differences were shown between sexes at lone atrial fibrillation and no treatment were begun. CONCLUSION: Women with atrial fibrillation had more risk factors, higher stroke rate and higher anticoagulation treatment. Key Words: Atrial fibrillation, stroke, women, CHADS2, CHA2DS2VASc, risk factors, age. GİRİŞAtriyal fibrilasyonun (AF) hakim olduğu kardiak aritmiler ciddi inmelere neden olarak tüm dünyada mortalite ve morbiditede önemli sonuçlar yaratırlar. Tüm yaş gruplarında AF insidansının erkeklerde daha yüksek olmasına rağmen AF'li kadınlar hala bilinmeyen nedenlerle daha yüksek oranlarda inme riski ile karşı karşıyadır ve önlenmesinde AF tedavisi kadınlarda daha özel _____________________________________________________________________________________________________________________________

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“…In a recently published study, females taking warfarin spent more time outside the therapeutic range than males, and more time below the therapeutic range, putting them at higher risk for ischemic stroke compared with males. 23 Unfortunately, we do not have data about time in the therapeutic range (TTR) with PT-INR in the patients taking warfarin. However, in this study, control of PT-INR was likely to be marginally lower in female than male patients, especially in those aged ≥70 years.…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Differences in the Clinical Events of Patients With Atrial Fibrillation　― The Fushimi AF Registry ―

Ogawa

Hamatani

Doi

et al. 2017

Circ J

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ies have reported conflicting results. 12, 13 In Japanese patients with AF, the J-RHYTHM registry concluded that female sex was not an independent risk factor for thromboembolic events and that male sex was a risk factor for major bleeding and all-cause death. 14 In addition, they validated that the 'CHA2DS2-VA score', excluding female sex, was performed similarly for risk stratification for thromboembolic events. 15 However, a Taiwanese study indicated that females had a higher rate of ischemic stroke than males among patients with AF who were not taking anticoagulants and aged <65 years. 16 In a Chinese AF A trial fibrillation (AF) is the most common cardiac arrhythmia and increases the risk of ischemic stroke and death. 1,2 Previous studies have indicated sex-related differences in the clinical characteristics and outcomes of AF patients. 3-6 Female sex is considered an increased risk for thromboembolism in patients with AF, albeit with an age-dependency (being relevant at age ≥65 or with other risk factors) and is included in the CHA2DS2-VASc score for stroke risk stratification. 7-10 A recent Swedish study also demonstrated that female AF patients aged ≥75 years are at higher risk of ischemic stroke, 11 but other stud- Background: Female sex is considered a risk factor for thromboembolism in patients with atrial fibrillation (AF), and is included in the risk stratification scheme, CHA2DS2-VASc score. The purpose of the present study was to investigate the clinical outcomes of female Japanese AF patients.

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Relation of Gender-Specific Risk of Ischemic Stroke in Patients With Atrial Fibrillation to Differences in Warfarin Anticoagulation Control (from AFFIRM)

Cited by 88 publications

References 13 publications

THE EFFICACY OF LONG-TERM WARFARIN THERAPY: THE IMPACT ON THE INCIDENCE OF ISCHEMIC CEREBROVASCULAR DISORDERS AND CLINICAL PREDICTORS OF DEVELOPING SUCH DISORDERS. (Results of a prospective 10-year follow-up study)

THE EFFICACY OF LONG-TERM WARFARIN THERAPY: THE IMPACT ON THE INCIDENCE OF ISCHEMIC CEREBROVASCULAR DISORDERS AND CLINICAL PREDICTORS OF DEVELOPING SUCH DISORDERS. (Results of a prospective 10-year follow-up study)

Women Sex Importance in Stroke Patients with Atrial Fibrillation

Sex-Related Differences in the Clinical Events of Patients With Atrial Fibrillation　― The Fushimi AF Registry ―

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Relation of Gender-Specific Risk of Ischemic Stroke in Patients With Atrial Fibrillation to Differences in Warfarin Anticoagulation Control (from AFFIRM)

Cited by 88 publications

References 13 publications

THE EFFICACY OF LONG-TERM WARFARIN THERAPY: THE IMPACT ON THE INCIDENCE OF ISCHEMIC CEREBROVASCULAR DISORDERS AND CLINICAL PREDICTORS OF DEVELOPING SUCH DISORDERS. (Results of a prospective 10-year follow-up study)

THE EFFICACY OF LONG-TERM WARFARIN THERAPY: THE IMPACT ON THE INCIDENCE OF ISCHEMIC CEREBROVASCULAR DISORDERS AND CLINICAL PREDICTORS OF DEVELOPING SUCH DISORDERS. (Results of a prospective 10-year follow-up study)

Women Sex Importance in Stroke Patients with Atrial Fibrillation

Sex-Related Differences in the Clinical Events of Patients With Atrial Fibrillation ― The Fushimi AF Registry ―

Contact Info

Product

Resources

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Sex-Related Differences in the Clinical Events of Patients With Atrial Fibrillation　― The Fushimi AF Registry ―