2013
DOI: 10.1002/oby.20432
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Abstract: Objective Increasing prevalence of childhood obesity and associated risks of adult type disease have led to worldwide concern. It remains unclear how genetic predisposition, environmental exposure to obesogenic food, and developmental programming interact to lead to overweight and obese children. The development of a nonhuman primate model of obesity, and particularly juvenile obesity, is an important step to elucidating the factors associated with obesity and evaluating intervention strategies. Design and M… Show more

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Cited by 19 publications
(14 citation statements)
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“…Both formula-feeding of human infants and early transition to solid foods are associated with higher growth velocities in infancy, though the relations of these variables to other potentially important variables, such as socioeconomic status can be extremely complex and difficult to decipher (Regnault et al, 2011; Wijlaars et al, 2011; May et al, 2012). While all the marmosets in our studies were breast-fed, we did find a positive relation between earlier occurrence of first observed solid food consumption and being classified as obese as juveniles – i.e., those animals that later became obese were observed eating solid food earlier (Tardif, unpublished observation; Ross et al, in press)…”
Section: Post-natal Growth In Mass and Its Relation To Litter Size Anmentioning
confidence: 65%
See 1 more Smart Citation
“…Both formula-feeding of human infants and early transition to solid foods are associated with higher growth velocities in infancy, though the relations of these variables to other potentially important variables, such as socioeconomic status can be extremely complex and difficult to decipher (Regnault et al, 2011; Wijlaars et al, 2011; May et al, 2012). While all the marmosets in our studies were breast-fed, we did find a positive relation between earlier occurrence of first observed solid food consumption and being classified as obese as juveniles – i.e., those animals that later became obese were observed eating solid food earlier (Tardif, unpublished observation; Ross et al, in press)…”
Section: Post-natal Growth In Mass and Its Relation To Litter Size Anmentioning
confidence: 65%
“…There was an association between higher fat food intake and adiposity at 6 months, with young that were classified as obese by 6 months consuming more, higher fat food. At 12 months, there was no longer an association of adiposity with higher fat food intake, but there was an association with overall food intake, with 12-month obese subjects consuming more food, overall (Ross et al, in press). …”
Section: Growth Rates In Relation To Obesity Developmentmentioning
confidence: 99%
“…Indeed, bonnet macaques that were exposed to a stressor postnatally show an increased prevalence of obesity (Kaufman et al, 2007). In addition, other experiential factors such as age at weaning are likely important, as data from marmoset monkeys indicate a earlier age at weaning predicts increased feeding behavior and an obese phenotype as juveniles (Ross et al, 2013). Because monkeys, like humans, have a relatively long gestation, more often have a single birth, and a protracted lactational period, they provide a unique opportunity to better define how maternal nutritional status affects offspring metabolic health…”
Section: Gaps In Understanding Feeding Behavior In Nonhuman Primatesmentioning
confidence: 99%
“…Most importantly, GB virus-B (GBV-B) belonging to the same family and genus as HCV causes an analogous disease to HCV in new world monkeys, including marmosets [3337]. In addition to their immunological similarity, marmosets have similar suites of body composition, alterations in glucose and lipid metabolism as observed in humans and other nonhuman primates [3841]. They are more prone to developing insulin resistance, diabetes mellitus, NAFLD and obesity and are used as models for the same conditions [3840].…”
Section: Introductionmentioning
confidence: 99%