Relation between shock-related myocardial injury and defibrillation efficacy of monophasic and biphasic shocks in a canine model

Resuscitation After Prolonged Ventricular Fibrillation With Use of Monophasic and Biphasic Waveform Pulses for External Defibrillation

“…12 Similarly, less harmful effects on mitochondrial function and oxidative metabolism have been documented after epicardial defibrillation with BP countershocks than after energy-matched MP countershocks. 19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF.…”

“…19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF. In the present study, BP defibrillation resulted in less severe functional consequences than did MP defibrillation.…”

Resuscitation After Prolonged Ventricular Fibrillation With Use of Monophasic and Biphasic Waveform Pulses for External Defibrillation

“…12 Similarly, less harmful effects on mitochondrial function and oxidative metabolism have been documented after epicardial defibrillation with BP countershocks than after energy-matched MP countershocks. 19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF.…”

“…19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF. In the present study, BP defibrillation resulted in less severe functional consequences than did MP defibrillation.…”

Ventricular fibrillation and defibrillation

“…Other studies of biphasic waveforms, of equal or lower energy doses, in adults,62 dogs61 and pigs69 have confirmed their beneficial effects in terms of post-shock myocardial oxidative metabolism,61 myocardial function69 and fewer skins burns 70…”

Comparison of Outcomes After Use of Biphasic or Monophasic Defibrillators Among Out-of-Hospital Cardiac Arrest Patients

“…To date, it has been indicated that biphasic waveform shock is superior to monophasic waveform shock with respect to safety and efficacy under controlled laboratory and in-hospital conditions. [3][4][5][6] An observational study of subjects with OHCA indicated that biphasic waveform shock afforded a higher probability of terminating VF than monophasic waveform shock. [7][8][9] With regard to the long-term outcome, no significant difference was observed between the 2 types of waveform for defibrillation in any of the 4 randomized trials.…”

Resuscitation After Prolonged Ventricular Fibrillation With Use of Monophasic and Biphasic Waveform Pulses for External Defibrillation

“…12 Similarly, less harmful effects on mitochondrial function and oxidative metabolism have been documented after epicardial defibrillation with BP countershocks than after energy-matched MP countershocks. 19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF.…”

“…19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF. In the present study, BP defibrillation resulted in less severe functional consequences than did MP defibrillation.…”

Ventricular fibrillation and defibrillation

“…Other studies of biphasic waveforms, of equal or lower energy doses, in adults,62 dogs61 and pigs69 have confirmed their beneficial effects in terms of post-shock myocardial oxidative metabolism,61 myocardial function69 and fewer skins burns 70…”

Comparison of Outcomes After Use of Biphasic or Monophasic Defibrillators Among Out-of-Hospital Cardiac Arrest Patients

“…To date, it has been indicated that biphasic waveform shock is superior to monophasic waveform shock with respect to safety and efficacy under controlled laboratory and in-hospital conditions. [3][4][5][6] An observational study of subjects with OHCA indicated that biphasic waveform shock afforded a higher probability of terminating VF than monophasic waveform shock. [7][8][9] With regard to the long-term outcome, no significant difference was observed between the 2 types of waveform for defibrillation in any of the 4 randomized trials.…”

Resuscitation After Prolonged Ventricular Fibrillation With Use of Monophasic and Biphasic Waveform Pulses for External Defibrillation

“…12 Similarly, less harmful effects on mitochondrial function and oxidative metabolism have been documented after epicardial defibrillation with BP countershocks than after energy-matched MP countershocks. 19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF.…”

“…19 In spite of these findings, differential effects on actual myocardial function by particular electrical waveforms have not previously been described. 19,20 Countershocks delivered in sinus rhythm had inconsequential effects on myocardial function; however, significant effects were apparent after countershock termination of brief VF. In the present study, BP defibrillation resulted in less severe functional consequences than did MP defibrillation.…”

Ventricular fibrillation and defibrillation

“…Other studies of biphasic waveforms, of equal or lower energy doses, in adults,62 dogs61 and pigs69 have confirmed their beneficial effects in terms of post-shock myocardial oxidative metabolism,61 myocardial function69 and fewer skins burns 70…”

Comparison of Outcomes After Use of Biphasic or Monophasic Defibrillators Among Out-of-Hospital Cardiac Arrest Patients

“…To date, it has been indicated that biphasic waveform shock is superior to monophasic waveform shock with respect to safety and efficacy under controlled laboratory and in-hospital conditions. [3][4][5][6] An observational study of subjects with OHCA indicated that biphasic waveform shock afforded a higher probability of terminating VF than monophasic waveform shock. [7][8][9] With regard to the long-term outcome, no significant difference was observed between the 2 types of waveform for defibrillation in any of the 4 randomized trials.…”