Relation between physical capacity, nutritional status and systemic inflammation in COPD

Hallin, Runa; Janson, Christer; Arnardóttir, Ragnheiður Harpa; Olsson, Roger; Emtner, Margareta; Branth, Stefan; Boman, Gunnar; Slinde, Frode

doi:10.1111/j.1752-699x.2010.00208.x

Cited by 29 publications

(31 citation statements)

References 31 publications

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“…It associates with important clinical variables (FEV 1 % predicted, exacerbation frequency and mMRC grade)19 and strongly correlates with the St George’s Respiratory Questionnaire 20. The most plausible explanation for the association of CRP with CAT scores is its implication in the systemic inflammatory process in COPD, and particularly its association with physical capacity5,21,22 and depression symptoms 23…”

Section: Discussionmentioning

confidence: 99%

Serum C-reactive protein level in COPD patients stratified according to GOLD 2011 grading classification

Lin

Wang

et al. 2016

Pak J Med Sci

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Background and Objective:The Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2011 grading classification has been used to evaluate the severity of patients with chronic obstructive pulmonary disease (COPD). However, little is known about the relationship between the systemic inflammation and this classification. We aimed to study the relationship between serum CRP and the components of the GOLD 2011 grading classification.Methods:C-reactive protein (CRP) levels were measured in 391 clinically stable COPD patients and in 50 controls from June 2, 2015 to October 31, 2015 in the First Affiliated Hospital of Xiamen University. The association between CRP levels and the components of the GOLD 2011 grading classification were assessed.Results:Correlation was found with the following variables: GOLD 2011 group (0.240), age (0.227), pack year (0.136), forced expiratory volume in one second % predicted (FEV1%; -0.267), forced vital capacity % predicted (-0.210), number of acute exacerbations in the past year (0.265), number of hospitalized exacerbations in the past year (0.165), British medical Research Council dyspnoea scale (0.121), COPD assessment test score (CAT, 0.233). Using multivariate analysis, FEV1% and CAT score manifested the strongest negative association with CRP levels.Conclusions:CRP levels differ in COPD patients among groups A-D based on GOLD 2011 grading classification. CRP levels are associated with several important clinical variables, of which FEV1% and CAT score manifested the strongest negative correlation.

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Section: Discussionmentioning

confidence: 99%

Serum C-reactive protein level in COPD patients stratified according to GOLD 2011 grading classification

Lin

Wang

et al. 2016

Pak J Med Sci

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“…A BMI <21 kg·m −2 is associated with significantly worse clinical outcomes [39]. Muscle or fat-free mass measurements may be even better predictors of clinical outcomes [223,224]. Acute involuntary weight loss is also important.…”

Section: Nutritionmentioning

confidence: 99%

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

et al. 2015

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this official American Thoracic Society (ATS)/European Respiratory Society (ERS) research statement is to describe evidence related to diagnosis, assessment and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management.Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarised, and then salient knowledge gaps were identified.Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus.Great strides have been made in the diagnosis, assessment and management of COPD, as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ ERS research statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centred outcomes. @ERSpublications ATS/ERS statement: which types of research will have the greatest future impact on patientcentred outcomes in COPD? http://ow.ly/I54Hb

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“…This is in accordance with our findings, which also revealed significant difference between the coursed distance by the patients with COPD and the predicted distance in ISWT. These physical ability results have been considered to be essentially important to express the functional capacity of patients with COPD, according to literature 7,13,14 .…”

Section: Discussionmentioning

confidence: 99%

Assessment of body composition, functional capacity and pulmonary function in patients with Chronic Obstructive Pulmonary Disease

et al. 2014

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Chronic obstructive pulmonary disease (COPD) is related to a low body mass index (BMI), reduced functional capacity and reduced bone density, thus justifying the importance of evaluating all of these parameters in the patients with the disease. This is a cross-sectional study, with sample consisting of 20 patients who performed measurement of body composition by bioelectrical impedance, evaluation of functional capacity by the distance traveled in the Incremental Shuttle Walk Test (ISWT) and assessment of severity of obstruction by spirometry. Significant differences were found between the travelled and scheduled distance in the ISWT (p<0.01), positive correlations between muscle mass and distance walked in ISWT (r=0.54 with p=0.01), with FEV1 (r=0.488 with p=0.02), FEV1 and bone mass (r=0.497 with p=0.02) and distance traveled with FEV1 (r=0,541 with p=0.01). The correlations found in this study, besides confirming the hypothesis that the severity of the obstruction presented by the change in the lung parenchyma in patients with COPD is related to changes in body composition and functional capacity reduction, also highlight the correlation with bone mass.

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Relation between physical capacity, nutritional status and systemic inflammation in COPD

Cited by 29 publications

References 31 publications

Serum C-reactive protein level in COPD patients stratified according to GOLD 2011 grading classification

Serum C-reactive protein level in COPD patients stratified according to GOLD 2011 grading classification

An official American Thoracic Society/European Respiratory Society statement: research questions in COPD

Assessment of body composition, functional capacity and pulmonary function in patients with Chronic Obstructive Pulmonary Disease

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