Relation between Helicobacter pylori infection and gastrointestinal symptoms and syndromes

Rosenstock, Steffen Jais; Kay, Lise; Rosenstock, C.; Andersen, Leif Percival; Bonnevie, O; Jørgensen, Torben

doi:10.1136/gut.41.2.169

Cited by 80 publications

(58 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…18 Some reports have described that dyspeptic symptoms were more frequent among H. pylori-positive patients. 19,20 Although changes in gastric acid secretion by H. pylori infection or functional abnormalities in gastric movement might contribute to dyspepsia, the relationship between them has not been fully clarified. Few reports have described the prevalence of H pylori with dyspepsia in a hospital setting.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in dyspeptic patients in Iran

Shokrzadeh

Baghaei

Yamaoka

et al. 2012

Gastroenterol Insights

View full text Add to dashboard Cite

Although Helicobacter pylori (H. pylori) infection has been known to be associated with several upper gastrointestinal disorders such as peptic ulcer and gastric cancer, the relationship between H. pylori infection and dyspeptic symptoms remains controversial. Furthermore, it is still not clear which factors are associated with H. pylori infection in the Iranian population. We investigated the prevalence of H. pylori infection in dyspeptic patients and factors associated with H. pylori infection in the Iranian population. In this cross-sectional study, 303 patients with dyspeptic symptoms underwent endoscopy. Clinical data and a questionnaire about gastrointestinal symptoms were collected from each patient. H. pylori status was evaluated by histological examination. Among the 303 patients, 263 (86.8%) were found to be positive for H. pylori. The prevalence of H. pylori infection decreased significantly with age. There was no difference in the prevalence of H. pylori infection between the patients with and those without a family history of gastroduodenal diseases. Among 250 patients with abdominal pain, 219 (87.6%) were infected with H. pylori. Among 211 patients with epigastric abdominal pain, 185 (87.7%) were infected with H. pylori. It was observed that belching was significantly associated with H. pylori infection (P = 0.03). Dyspepsia triggered by the consumption of tea was higher in H. pylori-positive patients than in H. pylori-negative patients (P=0.03). The prevalence of H. pylori infection in dyspeptic patients was quite high in Iran. Belching and dyspepsia triggered by tea consumption was related with H. pylori infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in dyspeptic patients in Iran

Shokrzadeh

Baghaei

Yamaoka

et al. 2012

Gastroenterol Insights

View full text Add to dashboard Cite

show abstract

“…Individuals with peptic ulcer disease whose symptoms are eliminated with treatment will not be diagnosed in hospital and could therefore be included as dyspepsia patients in this study. Dyspepsia patients are liable to self-medication [14], and Danish patients can buy smaller quantities of H 2 -receptor antagonists without a prescription. Therefore, it is possible that some respondents in the sample consumed H 2 -receptor antagonists or bismuth-containing compounds.…”

Section: Discussionmentioning

confidence: 99%

“…A Helicobacter pylori test is used to determine whether treatment should further include a course of two antibiotics (triple therapy) [5,8]. In scientific research, NSAIDs [3,9], exercise [1], peptic ulcer [3], age [3,[9][10][11][12][13], sex [1,[9][10][11]14,15], smoking [9,16], marital status [10], depression [9,11,13,17,18], sleep [1], BMI, and hypertension [9] have all been associated with dyspepsia. Psychological stress has been investigated as a risk factor for dyspepsia, with contradictory results.…”

Section: Introductionmentioning

confidence: 99%

Perceived stress as a risk factor for dyspepsia: a register-based cohort study

Deding

Torp‐Pedersen

Bøggild

2017

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

Objective Dyspepsia is a common condition and has a huge impact on quality of life and working capacity, but its causes are not well understood. An association between stress and dyspepsia has been debated for decades, but the issue has not been resolved. We examined the 3-year risk of redeeming a proton-pump inhibitor or an H2-receptor antagonist as a proxy of dyspepsia according to the level of perceived stress. Participants and methods Perceived stress was measured in a general health survey of 16 124 Danes aged older than 16 years of age in 2010 using Cohen’s Perceived Stress Scale. Data were linked individually to national registries, including the Danish National Prescription Registry. The risk of redeeming a proton-pump inhibitor or an H2-receptor antagonist for quintiles of stress level was estimated using Cox proportional hazard regression. Results In total, 2703 redeemed one of these drugs during the 33 months of follow-up. The cumulative incidence proportion of dyspepsia increased gradually, from 11.6 to 24.9%, with quintiles of stress. After full model adjustment, the four highest stress quintiles had a statistically significantly increased risk of redeeming a drug compared with the lowest stress quintile. The hazard ratios were 1.16 [95% confidence interval (CI): 1.00–1.34] for the second quintile, 1.21 (95% CI: 1.06–1.39) for the third quintile, 1.20 (95% CI: 1.05–1.38) for the fourth quintile, and 1.30 (95% CI: 1.12–1.50) for the fifth quintile. Conclusion Higher levels of self-reported perceived everyday life stress increased the risk of redeeming a drug for dyspepsia significantly during 33 months of follow-up.

show abstract

“…There is some evidence that a small proportion of subjects with H. pylori infection will develop symptoms in the future [32]and it is assumed that among patients with FD, a small number (probably candidates for developing peptic ulcer disease) may benefit from eradication therapy [33]. The meta-analysis of all randomized controlled studies showed a marginal 9% benefit of eradication therapy in FD patients [34].…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori Eradication or of Ranitidine plus Metoclopramide on Helicobacter pylori-Positive Functional Dyspepsia

et al. 2002

View full text Add to dashboard Cite

Background: A definitive treatment for functional dyspepsia (FD), and the role of Helicobacter pylori eradication on the course of this disease are controversial. Aim: To investigate the effect of a combination of acid-suppressing and prokinetic drugs or eradication therapy on the course of H. pylori-positive FD. Method: A total of 157 patients with endoscopically-proven H. pylori-positive FD and no response to 4 weeks of antacid therapy were randomly divided into 2 groups. 84 were placed on bismuth subnitrate plus metronidazole and amoxicillin (group A) and 73 received ranitidine and metoclopramide for 4 weeks (group B). The severity of symptoms (7 items) were assessed on a 6-point categorical scale. Group B patients who failed to respond to their medication underwent eradication therapy after 3 months. All patients were followed and assessed for 9 months after the end of therapy by the same clinicians who initiated the therapy. Results: At the end of the medication period, symptom’s score decreased significantly, and to the same extent. At 3-month follow-up moderate or complete response was achieved in 27.4% (group A) and 19.2% (group B) by intention-to-treat analysis. 34 patients of group B, not responding to treatment, underwent eradication therapy and followed as group A. Eradication of H. pylori was successful in 60 of 110 controlled patients (54%). After 9-month follow-up, complete or moderate response was observed in only 30% of 60 patients in whom H. pylori had been eradicated (intention-to-treat analysis), compared to 38% in 50 noneradicated cases (p > 0.05, 95% CI: 19–43 vs. 24–52). Conclusion: Eradication therapy with bismuth compound is effective as ranitidine plus metoclopramide in a subgroup of patients with FD not responding to antacid therapy. There is no difference in improvement between patients cured or not cured from H. pylori infection. This suggests that bismuth compounds were effective in FD when used in the eradication regimen. Combination therapy with acid-suppressing drugs plus prokinetic and bismuth seems to hold promise for FD.

show abstract

Relation between Helicobacter pylori infection and gastrointestinal symptoms and syndromes

Cited by 80 publications

References 42 publications

Prevalence of Helicobacter pylori infection in dyspeptic patients in Iran

Prevalence of Helicobacter pylori infection in dyspeptic patients in Iran

Perceived stress as a risk factor for dyspepsia: a register-based cohort study

Effect of <i>Helicobacter pylori</i> Eradication or of Ranitidine plus Metoclopramide on <i>Helicobacter pylori</i>-Positive Functional Dyspepsia

Contact Info

Product

Resources

About