Relation Between Herpes Simplex Viruses and Human Immunodeficiency Virus Infections

Severson, Jessica L.; Tyring, Stephen K.

doi:10.1001/archderm.135.11.1393

Cited by 64 publications

(43 citation statements)

References 56 publications

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“…En el paciente inmunocompetente las lesiones cutáneas se presentan en genitales externos, región perianal, cavidad oral y labios; son localizadas y están conformadas por lesiones que inician como vesículas pequeñas, dolorosas, agrupadas, con base eritematosa, que posteriormente se ulceran y resuelven en dos semanas sin tratamiento [5,8].…”

Section: Discussionunclassified

“…En los pacientes con deterioro en su sistema inmunológico, tal como son nuestros casos, las lesiones herpéticas ocurren con mayor frecuencia, son atípicas y poseen menor probabilidad de autolimitarse en comparación con las lesiones presentadas en pacientes inmunocompetentes [8]. En nuestro caso del paciente HIV negativo, con úlceras herpéticas perianales, el factor de inmunosupresión estaba dado por la leucopenia secundaria a la Leishmaniasis visceral, lo que nos demuestra que cualquier paciente inmunodeprimido es susceptible de padecer este tipo de lesiones y no sólo los casos vinculados al VIH.…”

Section: Discussionunclassified

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Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Domínguez¹,

Jara²,

Barboza³

et al. 2017

Our Dermatol Online

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Genital herpes is the most common cause of ulcers in sexually transmitted diseases (STDs). It is presented as a single or multiple, painful injury, accompanied by bilateral, also painful, lymphadenopathy. In immunocompromised patients, such as those affected by HIV, Herpes Simplex Virus (HSV) infections have a variety of clinical manifestations; they may be located, scattered or atypical. In addition, lesions may be more extensive and persistent than HIV-negative patients. We present two cases of immunocompromised patients with perianal herpetic ulcers, one HIV carrier, and the other with leukopenia caused by visceral Leishmaniasis.

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Section: Discussionunclassified

Perianal herpetic ulcers in immunosuppressed patients. Report of two cases

Domínguez¹,

Jara²,

Barboza³

et al. 2017

Our Dermatol Online

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“…In immunocompetent individuals, this can be painful and bothersome, but is rarely life threatening. Consequently, the dangers of herpes simplex are underestimated by most individuals, although HSV infections can become very prolonged and severe in patients with an impaired immune system or in neonates (4,5). Additionally, ocular diseases caused by herpes infections are one of the leading causes of blindness in the western world (6).…”

Section: Standard Treatment Of Herpes Simplex Virus Infectionsmentioning

confidence: 99%

“…Nonetheless, in recent years the incidence of genital herpes caused by HSV-1 has increased significantly in some developed countries (7), probably because a decreased likelihood of contracting HSV-1 infection during early childhood has led to increased chances of infection during sexual contact. This is particularly worrisome as genital herpes infections have been shown to at least double the risk of sexually-acquired HIV infections (5,8,9), with the prevalence of HSV-2 in HIV-infected individuals estimated to be as high as 90% in certain populations (10).…”

Section: Standard Treatment Of Herpes Simplex Virus Infectionsmentioning

confidence: 99%

Herpes simplex virus: Drug resistance and new treatment options using natural products (Review)

Mundinger

Efferth²

2008

Mol Med Rep

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Abstract. As herpes simplex infections are very common worldwide, new treatment options are of high importance, especially for immunosuppressed individuals. Although the standard treatment options have shown high effectiveness for decades, the risk that drug resistance will emerge remains significant. It is therefore important that new drug targets and new treatments are investigated, not just in preliminary tests, but also in vitro, in vivo and by clinical testing. One valuable source for new treatments is the abundance of molecules from natural products that have been shown to possess antiviral properties. Several potential candidates for the development of new anti-herpes drugs are discussed in this short review. Contents1. Standard treatment of herpes simplex virus infections 2. Natural products with anti-herpes simplex virus activity 3. Conclusions

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“…[1] HSV-2 infection is an independent risk factor for the acquisition and transmission of infection with human immunodeficiency virus 1(HIV-1). [2] Among co-infected persons, HIV-1 virions can be shed from herpetic lesions of the genital region. [2] This shedding may facilitate the spread of HIV through sexual contact.…”

Section: Introductionmentioning

confidence: 99%