Relation Between Electroencephalographic and Histologic Changes Following the Application of Graded Force to the Cortex

Abstract

THE electroencephalographic effects of trauma to the brain have been studied by a number of investigators. Williams and Denny\x=req-\ Brown,1 among others, have shown that a pathologic condition is indicated by the presence of slow waves of increased amplitude following a blow on the skull. These effects were produced experimentally on cats.The pathologic changes in the various cytologic elements following injury to the brain have also been studied by a number of investigators.The recent work of Rand and Courville describes in detail such his-From the

Neurometabolic Changes in the Acute Phase after Sports Concussions Correlate with Symptom Severity

“…However, when the brain is injured, in this case by a concussive blow, that metabolic balance is shifted. Concurrent with the initial spike and subsequent decrease in cerebral blood flow (Nilsson and Nordstrom, 1977a; Yuan et al, 1988), concussive injuries also cause a hyperexcited brain state via a mechanically-elicited neuronal discharge resulting in excitatory activity (Nilsson and Nordstrom, 1977b; Zimmerman and Putnam, 1947), that is not restricted to mechanoreceptors (Hu and Lewin, 2006; Morris, 1990; Sachs, 1991). This hyperexcited state puts a high metabolic demand on restoring the resting state, a key aspect of which is the production of ATP, resulting in a decrease of NAA.…”

Neurometabolic Changes in the Acute Phase after Sports Concussions Correlate with Symptom Severity

“…However, when the brain is injured, in this case by a concussive blow, that metabolic balance is shifted. Concurrent with the initial spike and subsequent decrease in cerebral blood flow (Nilsson and Nordstrom, 1977a; Yuan et al, 1988), concussive injuries also cause a hyperexcited brain state via a mechanically-elicited neuronal discharge resulting in excitatory activity (Nilsson and Nordstrom, 1977b; Zimmerman and Putnam, 1947), that is not restricted to mechanoreceptors (Hu and Lewin, 2006; Morris, 1990; Sachs, 1991). This hyperexcited state puts a high metabolic demand on restoring the resting state, a key aspect of which is the production of ATP, resulting in a decrease of NAA.…”

Neurometabolic Changes in the Acute Phase after Sports Concussions Correlate with Symptom Severity

“…However, when the brain is injured, in this case by a concussive blow, that metabolic balance is shifted. Concurrent with the initial spike and subsequent decrease in cerebral blood flow (Nilsson and Nordstrom, 1977a; Yuan et al, 1988), concussive injuries also cause a hyperexcited brain state via a mechanically-elicited neuronal discharge resulting in excitatory activity (Nilsson and Nordstrom, 1977b; Zimmerman and Putnam, 1947), that is not restricted to mechanoreceptors (Hu and Lewin, 2006; Morris, 1990; Sachs, 1991). This hyperexcited state puts a high metabolic demand on restoring the resting state, a key aspect of which is the production of ATP, resulting in a decrease of NAA.…”

Neurometabolic Changes in the Acute Phase after Sports Concussions Correlate with Symptom Severity

“…However, when the brain is injured, in this case by a concussive blow, that metabolic balance is shifted. Concurrent with the initial spike and subsequent decrease in cerebral blood flow (Nilsson and Nordstrom, 1977a; Yuan et al, 1988), concussive injuries also cause a hyperexcited brain state via a mechanically-elicited neuronal discharge resulting in excitatory activity (Nilsson and Nordstrom, 1977b; Zimmerman and Putnam, 1947), that is not restricted to mechanoreceptors (Hu and Lewin, 2006; Morris, 1990; Sachs, 1991). This hyperexcited state puts a high metabolic demand on restoring the resting state, a key aspect of which is the production of ATP, resulting in a decrease of NAA.…”