Relation between cardiovascular risk factors and nonrheumatic severe calcific aortic stenosis among patients with a three-cuspid aortic valve

Peltier, Marcel; Trojette, Faouzi; Sarano, Maurice E.; Grigioni, Francesco; Slama, Michel; Tribouilloy, Christophe

doi:10.1016/s0002-9149(02)03010-2

Cited by 101 publications

(50 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings have been confirmed in many other retrospective databases across the country. [5][6][7][8][9] These studies provide the basis that atherosclerotic risk factors play a role in the development of this disease process.…”

Section: Article P 2065mentioning

confidence: 98%

Calcific Aortic Stenosis

Rajamannan

2006

Circulation

View full text Add to dashboard Cite

Section: Article P 2065mentioning

confidence: 98%

Calcific Aortic Stenosis

Rajamannan

2006

Circulation

View full text Add to dashboard Cite

“…Several lines of evidence have demonstrated that degenerative AS is an active process in which inflammation plays a key role. As such, preventative approaches similar to those used in coronary artery disease (CAD) may be also applicable to AS (2,3,4,5,6). However, recent studies reported no reduction in later states of AS disease using statins, which significantly benefit patients with atherosclerosis (7,8).…”

Section: Degenerative Aortic Stenosis (As)mentioning

confidence: 99%

Modification of the Secretion Pattern of Proteases, Inflammatory Mediators, and Extracellular Matrix Proteins by Human Aortic Valve is Key in Severe Aortic Stenosis

Alvarez-Llamas

Martín-Rojas

Cuesta

et al. 2013

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

One of the major challenges in cardiovascular medicine is to identify candidate biomarker proteins. Secretome analysis is particularly relevant in this search as it focuses on a subset of proteins released by a cell or tissue under certain conditions. The sample can be considered as a plasma subproteome and it provides a more direct approximation to the in vivo situation. Degenerative aortic stenosis is the most common worldwide cause of valve replacement. Using a proteomic analysis of the secretome from aortic stenosis valves we could identify candidate markers related to this pathology, which may facilitate early diagnosis and treatment. For this purpose, we have designed a method to validate the origin of secreted proteins, demonstrating their synthesis and release by the tissue and ruling out blood origin. The nLC-MS/MS analysis showed the labeling of 61 proteins, 82% of which incorporated the label in only one group. Western blot and selective reaction monitoring differential analysis, revealed a notable role of the extracellular matrix. Variation in particular proteins such as PEDF, cystatin and clusterin emphasizes the link between aortic stenosis and atherosclerosis. In particular, certain proteins variation in secretome levels correlates well, not only with label incorporation trend (only labeled in aortic stenosis group) but, more importantly, with alterations found in plasma from an independent cohort of samples, pointing to specific candidate markers to follow up in diagnosis, prognosis, and therapeutic intervention. Molecular & Cellular Proteomics 12:

show abstract

“…Indeed, in a purely atherosclerotic hypothesis of calcification progression, 14 the fact that most patients with severe AS attributable to massive valve calcification present without obstructive CAD, 15,48,49 would be incomprehensible. AVC, after the initial atherosclerotic phase, grows independently of most risk factors.…”

Section: Avc and Subclinical Coronary Artery Atherosclerosismentioning

confidence: 99%