Relation Between Animal-Type Melanoma and Reduced Nuclear Expression of Glutathione S-Transferase π

Orlandi, Augusto; Costantini, Sara; Campione, Elena; Ferlosio, Amedeo; Amantea, A.; Bianchi, Luca; Chimenti, Sergio; Spagnoli, Luigi Giusto

doi:10.1001/archderm.145.1.55

Cited by 22 publications

(28 citation statements)

References 33 publications

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“…In conventional melanomas with similar thickness and no ulceration, 5-year survival rate was 70%. 6 The longest follow-up period (67 months) was reported by Mandal et al 7 All 26 patients were free of disease during the follow-up period. 7 Present case report is the first to describe a patient with animal-type melanoma who has had the lesion since birth and who is still living despite having the tumor for 38 years.…”

Section: Discussionmentioning

confidence: 91%

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Survival for 38 years with Animal-type malignant melanoma

et al. 2014

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Animal-type melanoma is a low-grade malignant tumor with a good prognosis. Although it is common in old grey horses, the tumor is exceedingly rare in humans. Only 173 cases have been reported till 2011. We report a case in a 38-year-old woman who had the neoplasm in the left labium majus since birth. The tumor was composed of heavily melanized polygonal tumor cells with mildly atypical nuclei proliferating diffusely and in nests in the dermis and subcutis with invasion of hair follicles and nerve bundles. Mitotic figures were not seen. Regional lymph nodes were not enlarged. Present case describes a patient with animal-type melanoma who has had the lesion since birth and who is still living despite having the tumor for 38 years. It attests to the fact that this tumor has indolent biologic behaviour despite being malignant. Mistaking this case for other highly pigmented melanocytic tumors, benign or malignant, is a potential diagnostic pitfall.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11599 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 685-687

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Section: Discussionmentioning

confidence: 91%

“…Even if it metastasizes, its prognosis is better than that of conventional malignant melanoma with the same depth of invasion. 5 In a review of 18 cases of animaltype melanoma by Orlandi et al 6 , 5-year survival rate was found to be 94%. In conventional melanomas with similar thickness and no ulceration, 5-year survival rate was 70%.…”

Section: Discussionmentioning

confidence: 99%

Survival for 38 years with Animal-type malignant melanoma

et al. 2014

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“…As células do melanoma tipo animal demonstram típica positividade para proteína S-100, vimentina, HMB-45 e Melan-A (7) . A utilização de substâncias descolorantes para remoção da melanima não é recomendada, pois pode prejudicar e mesmo causar a perda da marcação com anticorpos Melan-A e HMB-45 (6) .…”

Section: Discussionunclassified

“…A investigação da isoforma pi da glutationa S-transferase, família de enzimas envolvida na progressão tumoral, revelou que sua expressão nuclear está diminuída em melanomas do tipo animal quando comparada à expressão em melanomas em geral (7) . A expressão da subunidade reguladora 1alfa (R1alfa), codificada pelo gene PRKAR1A, está ausente na maioria dos melanomas tipo animal, mas não nos melanomas equinos e em outras lesões melanocíticas, como nevo azul celular, nevo azul maligno e outros tipos de melanoma.…”

Section: Discussionunclassified

nbsp; language=pt]Melanoma tipo animal: relato de dois casos

Marques

Yamashita²,

Marques³

et al. 2010

J. Bras. Patol. Med. Lab.

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Dificuldade potencial no diagnóstico histológico de melanomas é a dificuldade em reconhecer variantes pouco frequentes de melanoma. Entre elas, as mais desafiantes incluem exemplos de melanoma desmoplásico, melanoma nevoide, o chamado "melanoma de desvio mínimo", melanomas com proeminente síntese de pigmento ou "melanoma tipo animal" e o nevo azul maligno. Os autores descrevem dois casos de melanoma tipo animal e discute-se a importância do diagnóstico diferencial clinico-histopatológico nesses casos.

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“…Among the GST family, GST-π is widely expressed in various human epithelial tissues (37), and is common in ovarian tumors (38).…”

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confidence: 99%

Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways

Liu

Yang

et al. 2011

Mol Med Report

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Abstract. Cisplatin (CDDP) is a major chemotherapeutic drug used in the treatment of human ovarian cancer. Tubeimoside I (TBMS1) has also shown potent antitumor and antitumorpromoting effects, and may offer a promising new approach in the effective treatment of CDDP-resistant human ovarian cancers. This study aimed to investigate the effect of TBMS1 in sensitizing CDDP in CDDP-resistant human ovarian cancer cells (A2780/DDP). A variety of methods were employed to measure cell apoptosis, p38, ERK1/2 and glutathione S-transferase (GST)-π expressions. It was found that TBMS1 combined with CDDP promoted cell apoptosis, decreased proliferation activity and increased cytosolic Ca 2+ levels. Bcl-2 protein expression was down-regulated but Bax was up-regulated. Moreover, GST-π mRNA and protein expression were decreased. TBMS1 reduced the resistance of the cells to CDDP-induced cytotoxicity. Both the p38 inhibitor (SB203580) and the ERK1/2 inhibitor (PD98059) effectively blocked this effect. These results suggest that TBMS1 can effectively sensitize CDDP in CDDP-resistant human ovarian cancer cells through the down-regulation of the ERK1/2 and the up-regulation of the p38 signaling pathways.

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Relation Between Animal-Type Melanoma and Reduced Nuclear Expression of Glutathione S-Transferase π

Cited by 22 publications

References 33 publications

Survival for 38 years with Animal-type malignant melanoma

Survival for 38 years with Animal-type malignant melanoma

nbsp; language=pt]Melanoma tipo animal: relato de dois casos

Tubeimoside I sensitizes cisplatin in cisplatin-resistant human ovarian cancer cells (A2780/DDP) through down-regulation of ERK and up-regulation of p38 signaling pathways

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