Relating isobolograms to response surfaces

An isobole-based statistical model and test for synergism/antagonism in binary mixture toxicity experiments

“…This is contrary to most other approaches where the additivity line is based only on data from the pure chemicals Berenbaum (1985Berenbaum ( , 1989; Carter (1995); Gessner (1995). The rationale for our approach is that if there is Concentration Addition, then all mixtures contain information about the ed 50 -values, δ 1 and δ 2 , for the pure chemical parameters.…”

An isobole-based statistical model and test for synergism/antagonism in binary mixture toxicity experiments

“…This is contrary to most other approaches where the additivity line is based only on data from the pure chemicals Berenbaum (1985Berenbaum ( , 1989; Carter (1995); Gessner (1995). The rationale for our approach is that if there is Concentration Addition, then all mixtures contain information about the ed 50 -values, δ 1 and δ 2 , for the pure chemical parameters.…”

Tobramycin and bicarbonate synergise to kill planktonic Pseudomonas aeruginosa, but antagonise to promote biofilm survival

“…Isobolograms are a standard and widely used approach to examine drug interactions. 28 Although they offer valuable insights, they do have limitations: The actual MIC value of an agent or combination of agents may be overestimated when testing using serial dilutions. This results in an underestimation of synergy.…”

A Random Effects Model for Binary Mixture Toxicity Experiments

“…, d C ) is a mixture concentration yielding 50% effect. A generalization of either (3.2) or (3.3) would also be possible (Jonker et al 2005;Carter 1995). [Published Online September 2010.…”

An isobole-based statistical model and test for synergism/antagonism in binary mixture toxicity experiments

“…This is contrary to most other approaches where the additivity line is based only on data from the pure chemicals Berenbaum (1985Berenbaum ( , 1989; Carter (1995); Gessner (1995). The rationale for our approach is that if there is Concentration Addition, then all mixtures contain information about the ed 50 -values, δ 1 and δ 2 , for the pure chemical parameters.…”

Tobramycin and bicarbonate synergise to kill planktonic Pseudomonas aeruginosa, but antagonise to promote biofilm survival

“…Isobolograms are a standard and widely used approach to examine drug interactions. 28 Although they offer valuable insights, they do have limitations: The actual MIC value of an agent or combination of agents may be overestimated when testing using serial dilutions. This results in an underestimation of synergy.…”

A Random Effects Model for Binary Mixture Toxicity Experiments

“…, d C ) is a mixture concentration yielding 50% effect. A generalization of either (3.2) or (3.3) would also be possible (Jonker et al 2005;Carter 1995). [Published Online September 2010.…”

An isobole-based statistical model and test for synergism/antagonism in binary mixture toxicity experiments

“…This is contrary to most other approaches where the additivity line is based only on data from the pure chemicals Berenbaum (1985Berenbaum ( , 1989; Carter (1995); Gessner (1995). The rationale for our approach is that if there is Concentration Addition, then all mixtures contain information about the ed 50 -values, δ 1 and δ 2 , for the pure chemical parameters.…”

Tobramycin and bicarbonate synergise to kill planktonic Pseudomonas aeruginosa, but antagonise to promote biofilm survival

“…Isobolograms are a standard and widely used approach to examine drug interactions. 28 Although they offer valuable insights, they do have limitations: The actual MIC value of an agent or combination of agents may be overestimated when testing using serial dilutions. This results in an underestimation of synergy.…”

A Random Effects Model for Binary Mixture Toxicity Experiments

“…, d C ) is a mixture concentration yielding 50% effect. A generalization of either (3.2) or (3.3) would also be possible (Jonker et al 2005;Carter 1995). [Published Online September 2010.…”