Relapsing Polychondritis and Malignant Lymphoma

Yanagi, Teruki; Matsumura, Tomohiro; Kamekura, Ryuta; Sasaki, Noriko; Hashino, Satoshi

doi:10.1001/archderm.143.1.89

Cited by 36 publications

(20 citation statements)

References 7 publications

(2 reference statements)

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“…Nevertheless, our review showed only one case associated with nonspecific colitis [13], unlike our case.…”

Section: Check For Updatescontrasting

confidence: 67%

“…Other hematological malignancies have been reported in association with RP: leukemia has been found 11 cases [4,[8][9][10], nonHodgkin lymphoma in 6 cases [8,[11][12][13][14], multiple myeloma [6,15,16], myeloproliferative disorders and Hodgkin disease [14,17,18] in respectively 3, 3 and 2 cases (Table 1).…”

Section: Check For Updatesmentioning

confidence: 99%

“…There is probably a common trigger that links the two diseases. The autoimmune basis is more and more raised, but it part in the pathogenesis of paraneoplastic RP has not yet been obvious [13,[31][32][33][34]. Of note, treatment may induce remission of the two diseases.…”

Section: Check For Updatesmentioning

confidence: 99%

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Untitled

2016

J Dermatol Res Ther

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Some case reports and series presumed a link between malignancy and relapsing polychondritis. The most frequent described neoplasms have been hematological disorders especially myelodysplastic syndromes. Less commonly have also been reported solid neoplasms as colorectal cancer like our patient. We suggest that patients with RP should be monitored more carefully even in remission for early detection of cancer.On admission to our department, physical examination revealed thickening of both external ears with erythema of the auricles with a saddle-nose. Fine rales over both lower lung fields were heard. Ophtalmological examination revealed bilateral anterior uveitis.Computed tomography of the chest disclosed stenosis of the trachea, swelling of cartilages and bilateral main bronchus (Figure 1).All the laboratory data was with the normal range. Antinuclear antibody was negative. Auricle biopsy showed a lymphocytic infiltration around the blood vessels, which is compatible with RP. Given that our patient has recurrent chondritis of auricles, nasal cartilage and the upper respiratory tract, recurrent uveitis, the diagnosis of RP was made and the patient was treated with Prednisone: 30 mg/day for 3 weeks and the dose of prednisone was tapered with no relapse.He was admitted 3 years after for acute rectal bleeding. The pulse rate was 110 per minute, and his blood pressure was 110/70 mmHg. He stated that he lost 10 Kg in weight 2 months before. Besides, he complained of lower abdominal pain and bloody diarrhea.Laboratory studies revealed anemia at 6.9 g/dl, the leukocyte count: 5690/mm 3 , the platelets count: 423000/mm 3 . Serum electrolytes, creatinine and liver tests were with the normal range. The stool culture was negative.Tumor markers were checked: PSA were normal but he had marked elevation of CEA, CA19-9 markers of up to 325 ng/ml. The patient was transfused. Abdominal computed tomography revealed a thickness of the descending colon wall, a liver mass on the right lobe and a necrotic adenopathy (Figure 2). Colonoscopy revealed an ulcer formation and bleeding from the sigmoid colon. Colic tumor specimen showed undifferentiated adenocarcinoma. An extended right colectomy was performed. A subsequent chemotherapy was administrated. He was discharged and still receiving Prednisone: 10 mg/day without flare-up of RP.

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“…Nevertheless, our review showed only one case associated with nonspecific colitis [13], unlike our case.…”

Section: Check For Updatescontrasting

confidence: 67%

Section: Check For Updatesmentioning

confidence: 99%

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Untitled

2016

J Dermatol Res Ther

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“…Twenty-two out of 200 patients with relapsing polychondritis had an associated myelodysplastic syndrome in one study [50]. Cases of relapsing polychondritis-associated with lymphoma have also been reported [51].…”

Section: Other Paraneoplastic Rheumatic Syndromesmentioning

confidence: 99%

Paraneoplastic rheumatologic syndromes

Azar

Khasnis

2013

Current Opinion in Rheumatology

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“…There has been an association with various underlying neoplastic disorders including tumors of the bladder, breast, bronchus, colon, lung pancreas, rectum and vocal cords [38]. Perhaps the most frequent association is in the context of underlying lymphoreticular and myeloid dyscrasia [39]. If there are concomitant mouth and genital ulcers, the syndromic complex falls under the designation of MAGIC (i.e.…”

Section: Relapsing Polychondritismentioning

confidence: 99%

Angiocentric Lesions of the Head and Neck

Magro

Dyrsen

2008

Head and Neck Pathol

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Angiocentric lesions of the head and neck encompass a variety of benign and malignant lesions. Not unexpectedly the sequelae of an angiocentric process independent of its benign or malignant nature is one of tissue ischemia with a potential for either breakdown or reparative fibrosis. Therefore, the clinical presentations can be very similar despite a varied pathogenesis. Among the benign reactive infiltrates that will be considered are angiocentric eosinophilic fibrosis, Wegener's granulomatosis, microscopic polyangiitis and cocaine associated mid line facial destruction. We will discuss other conditions which enter into the differential diagnosis either clinically or histologically including Erdheim Chester disease and mid line facial undermining unrelated to an angiocentric event specifically in the context of trigeminal trophic ulcer and relapsing polychondritis. The two main neoplastic conditions exhibiting angiocentricity are in the context of lymphomatoid granulomatosis and NK/T cell lymphoma; hence these two particular hematologic dyscrasias will be discussed in some detail in this review.

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Relapsing Polychondritis and Malignant Lymphoma

Cited by 36 publications

References 7 publications

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Paraneoplastic rheumatologic syndromes

Angiocentric Lesions of the Head and Neck

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