Relação entre aterosclerose subclínica, pressão arterial e perfil lipídico em crianças e adolescentes obesos: uma revisão sistemática

Pizzi, J.R.; Silva, Larissa Rosa da; Moser, Deise Cristiane; Leite, Neiva

doi:10.1590/s0004-27302013000100001

Cited by 13 publications

(11 citation statements)

References 23 publications

(28 reference statements)

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“…Studies indicate that the process of atherosclerosis begins in childhood and is related to obesity and cardiovascular risk factors, such as hypertension, dyslipidemias and changes in glucose metabolism 10,11,27. In adolescents, carotid intima-media thickness, which is considered a subclinical marker of atherosclerosis, has been found to be positively correlated with parameters of metabolic syndrome, including LDL-C, low HDL-C, TG, subcutaneous abdominal fat volume, visceral fat volume and blood pressure 27,28.…”

Section: Discussionmentioning

confidence: 99%

“…In adolescents, carotid intima-media thickness, which is considered a subclinical marker of atherosclerosis, has been found to be positively correlated with parameters of metabolic syndrome, including LDL-C, low HDL-C, TG, subcutaneous abdominal fat volume, visceral fat volume and blood pressure 27,28. In the present study, changes in lipid metabolism were highly relevant, and the obese group exhibited higher means of total cholesterol, LDL-C, TG and TG/HDL-C compared with the overweight group.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Palhares¹,

Silva²,

Resende³

et al. 2017

Clinics

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OBJECTIVE:This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents.METHODS:The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels). The frequency of changes, odds ratios and correlations among markers were determined. Metabolic syndrome was assessed according to International Diabetes Federation criteria.RESULTS:A high frequency of acanthosis (51.6%); increased waist circumference (45.4%), systolic blood pressure / diastolic blood pressure (8.1% / 9.3%), glucose (10%), insulin (36.9%) and HOMA-IR (44.3%) values; and reduced high-density lipoprotein levels (47.2%) were observed. Leptin levels were increased in 95% of obese and in 66% of overweight subjects. Adiponectin was decreased in 29.5% of obese and in 34% of overweight subjects. An odd ratio analysis revealed a greater probability of increased waist circumference (9.0), systolic blood pressure (4.1), triglyceride (2.3) and insulin (2.9) levels and HOMA-IR (3.0) in the obese group than in the overweight group. The clinical and laboratory parameters and leptin levels exhibited significant correlations, whereas adiponectin was negatively correlated with systolic blood pressure. The occurrence rate of metabolic syndrome was 13.6%.CONCLUSIONS:The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Palhares¹,

Silva²,

Resende³

et al. 2017

Clinics

View full text Add to dashboard Cite

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“…According to the Household Budget Survey (HBS) 2008-2009, children between 5 and 9 years old, present a lower prevalence for malnutrition and higher for obesity, with a weight deficit diagnosed at 4.1% and overweight in 33.5% of Brazilian children 27 . The increase in body adiposity may contribute to changes in lipid profile and cardiovascular risk in adult life 28 .…”

Section: Discussionmentioning

confidence: 99%

Dislipidemia familiar e fatores associados a alterações no perfil lipídico em crianças

Souza

Vieira

Fonseca

et al. 2019

Ciênc. saúde coletiva

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Resumo O objetivo deste artigo é avaliar a prevalência de dislipidemia e os fatores associados em crianças de 4 a 7 anos de idade. Estudo transversal, realizado com 402 crianças de 4 a 7 anos de idade, acompanhadas por um Programa de Apoio a Lactação nos primeiros seis meses de vida. Foram dosados colesterol total, triglicerídeos e lipoproteínas de alta (HDL) e baixa densidades (LDL). Selecionou-se variáveis que poderiam estar associadas ao perfil lipídico, como o histórico familiar de dislipidemia, estado nutricional e o consumo alimentar das crianças. Realizou-se análise de Regressão de Poisson com variância robusta. O nível de significância adotado foi de p < 0,05. Observou-se valores aumentados da LDL em 46,8% (188), colesterol total em 37,6% (151), triglicerídeos em 10,4% (42) e HDL abaixo do desejável em 33,8% (136) das crianças. Houve associação estatisticamente significativa entre o histórico familiar de dislipidemia com colesterol total, LDL e triglicerídeos (p < 0,05 e p < 0,001, respectivamente); Desmame precoce com LDL (p < 0,05); Sedentarismo com LDL e triglicerídeos (p < 0,05 e p < 0,001, respectivamente); bem como HDL com o consumo de bala (p < 0,05). Houve importante prevalência de alterações no perfil lipídico das crianças. São necessárias atividades de educação nutricional e programas voltados para esse grupo.

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“…Arterial endothelium dysfunction is an early abnormality during atherogenesis and is an indication of arterial damage since it precedes the formation of atheromatous plaques (Pizzi et al, 2013). Endothelium-dependent vascular response analysis is clinically important for the study of endothelial function.…”

Section: Introductionmentioning

confidence: 99%

Research Article The <i>eNOS</i> T786C polymorphism is not related to atherosclerosis and cofactors in a Brazilian population

Oliveira¹,

Correa²,

Silva³

et al. 2019

Genet. Mol. Res.

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Relação entre aterosclerose subclínica, pressão arterial e perfil lipídico em crianças e adolescentes obesos: uma revisão sistemática

Cited by 13 publications

References 23 publications

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

Dislipidemia familiar e fatores associados a alterações no perfil lipídico em crianças

Research Article The <i>eNOS</i> T786C polymorphism is not related to atherosclerosis and cofactors in a Brazilian population

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