2005
DOI: 10.1038/nature03260
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Abstract: The decline of tissue regenerative potential is a hallmark of ageing and may be due to age-related changes in tissue-specific stem cells. A decline in skeletal muscle stem cell (satellite cell) activity due to a loss of Notch signalling results in impaired regeneration of aged muscle. The decline in hepatic progenitor cell proliferation owing to the formation of a complex involving cEBP-alpha and the chromatin remodelling factor brahma (Brm) inhibits the regenerative capacity of aged liver. To examine the infl… Show more

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Cited by 1,909 publications
(1,751 citation statements)
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References 25 publications
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“…in vitro systems have confirmed the exquisite sensitivity of stem cells to extrinsic mechanical and structural cues emanating from the surrounding microenvironment (Engler et al ., 2006; Gilbert et al ., 2010). In vivo studies investigating modulation of the microenvironment have similarly demonstrated effects on the proliferation, migration, and myogenicity of both endogenous (Conboy et al ., 2005; Brack et al ., 2007) and transplanted MuSCs (Palermo et al ., 2005; Gargioli et al ., 2008; Ambrosio et al ., 2009, 2010; Distefano et al ., 2013), effects that ultimately affect muscle regeneration and function (Ambrosio et al ., 2009; Distefano et al ., 2013). Still, little is known about how aging affects properties of the skeletal muscle ECM and how such alterations may affect MuSC fate.…”
Section: Introductionmentioning
confidence: 99%
“…in vitro systems have confirmed the exquisite sensitivity of stem cells to extrinsic mechanical and structural cues emanating from the surrounding microenvironment (Engler et al ., 2006; Gilbert et al ., 2010). In vivo studies investigating modulation of the microenvironment have similarly demonstrated effects on the proliferation, migration, and myogenicity of both endogenous (Conboy et al ., 2005; Brack et al ., 2007) and transplanted MuSCs (Palermo et al ., 2005; Gargioli et al ., 2008; Ambrosio et al ., 2009, 2010; Distefano et al ., 2013), effects that ultimately affect muscle regeneration and function (Ambrosio et al ., 2009; Distefano et al ., 2013). Still, little is known about how aging affects properties of the skeletal muscle ECM and how such alterations may affect MuSC fate.…”
Section: Introductionmentioning
confidence: 99%
“…Those observations indicated a role for the tissue environment extrinsic to muscle cells in regulating their regeneration. Similarly, heterochronic parabiosis experiments showed that exposure of aged satellite cells to a youthful environment could enhance the regenerative capacity of the skeletal muscle from old animals (Conboy et al, 2005). However, other investigators reported that transplanting old satellite cells into a young environment failed to restore the phenotype or myogenic capacity of satellite cells (Bernet et al, 2014; Cosgrove et al, 2014).…”
Section: Introductionmentioning
confidence: 99%
“…By applying this technique, Conboy et al. found that the muscle and liver from the aged partner of the heterochronic pairs exhibited youthful levels of regeneration (Conboy et al., 2005). A similar “rejuvenating” effect of young blood has been demonstrated in other organs, including the spinal cord (Ruckh et al., 2012), heart (Loffredo et al., 2013), brain (Katsimpardi et al., 2014) (Villeda et al., 2014), β‐cells (Salpeter et al., 2013), and hair follicles (Keyes et al., 2013).…”
Section: Introductionmentioning
confidence: 99%