2015
DOI: 10.18632/oncotarget.3740
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Abstract: The 2014 year ended with celebration: Everolimus, a rapamycin analog, was shown to improve immunity in old humans, heralding ‘a turning point’ in research and new era in human quest for immortality. Yet, this turning point was predicted a decade ago. But what will cause human death, when aging will be abolished?

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Cited by 28 publications
(23 citation statements)
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References 130 publications
(64 reference statements)
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“…Inhibition of TOR signaling by rapamycin has been shown to extend lifespan in wild type populations of numerous species [16, 28], and in mouse and worm models of mitochondrial disease [12, 14, 29]. Results from our group and others support a role for rapamycin in metabolic reprogramming, rescuing energy deficits in mitochondrial disease.…”
Section: Discussionmentioning
confidence: 58%
“…Inhibition of TOR signaling by rapamycin has been shown to extend lifespan in wild type populations of numerous species [16, 28], and in mouse and worm models of mitochondrial disease [12, 14, 29]. Results from our group and others support a role for rapamycin in metabolic reprogramming, rescuing energy deficits in mitochondrial disease.…”
Section: Discussionmentioning
confidence: 58%
“…Rapamycin decreases obesity in mice and humans [8789]. As predicted [1], rapalogs rejuvenate immunity, improve immune response in aging mice [90] and humans [30, 91, 92]. Prevention of all age-related diseases by rapalogs was discussed in detail [1, 2, 13, 14, 17, 18, 24, 26, 29, 32 9395],…”
Section: Rapalogs: Rapamycin (Sirolimus/rapamune) and Everalimusmentioning
confidence: 98%
“…A major breakthrough occurred in 2009 when it was shown that rapamycin, which reduced mTOR signaling, increased the lifespan of mice (see review in [4]). In addition, rapamycin has been shown to reduce a variety of cancers in mice as well as atherosclerosis in mouse models fed high fat diets as well as improve immunity in elderly humans [5]. As regard to the human central nervous system, several studies have shown that inhibition of mTOR by rapamycin treatment improves cognition, slows brain aging, and impedes the progress of neurodegenerative disorders through pathways associated with autophagy, glucose metabolism and mitochondrial functions [6].…”
mentioning
confidence: 99%