Reirradiation for patients with recurrence head and neck squamous cell carcinoma: A single-institution comparative study

Rudžianskas, Viktoras; Inčiūra, Arturas; Vaitkus, Saulius; Padervinskis, Evaldas; Rudžianskienė, Milda; Kupčinskaitė-Noreikienė, Rita; Saltonaitė, Lina; Noreika, A.; Statnickaitė, Akvilė; Juozaitytė, Elona

doi:10.1016/j.medici.2014.06.006

Cited by 22 publications

(19 citation statements)

References 25 publications

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“…Adjuvant treatment is rational and potentially useful after salvage surgery, and we administered this treatment via interstitial HDR IRT. This use is likely the most frequent perioperative use of IRT in head and neck oncology and was validated in international studies with very encouraging oncological results . We most often associated this treatment with reconstructive procedures (77%) because most of treated lesions were bulky and extensively involved the skin.…”

Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

“…A potentially curative dose may be delivered via brachytherapy in patients who are otherwise mostly candidates for palliation or best supportive care when radical resection is not considered feasible. [14][15][16][17][18][19][20][21] We recommend brachytherapy in these cases only if we see the perspective of a curative treatment, which can be obtained only with a complete coverage of the tumor volume, and at the same time a low-risk catheter placement. Strictly sticking to these selection criteria, only a few otherwise untreatable patients with cheek/buccal mucosa and floor of mouth recurrences were treated with exclusive interstitial IRT.…”

Section: Group I: Exclusive Interstitial Brachytherapy In Recurrencmentioning

confidence: 99%

“…This use is likely the most frequent perioperative use of IRT in head and neck oncology and was validated in international studies with very encouraging oncological results. 6,18,23 We most often associated this treatment with reconstructive procedures (77%) because most of treated lesions were bulky and extensively involved the skin. The pectoralis major flap remains the workhorse in this setting, 24 but we also successfully used free flaps.…”

Section: Group Iii: Perioperative Interstitial Irt For Neck Recurrementioning

confidence: 99%

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HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

et al. 2019

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Background Interventional radiotherapy (brachytherapy; IRT) reemerged in the last decades as a potentially useful tool in head and neck oncology after a set of clear technical improvements were developed. Methods Sixty‐one high dose ratio (HDR) IRT treatments were recommended and performed on 58 patients. We classified the cases into four relatively homogeneous groups based on the clinical needs that led to the recommended IRT. Also, we separately evaluated primary and recurrent cases. Results Disease‐specific survival was significantly different among the four treatment groups. The group with the best prognosis was the cohort treated locally by exclusive interstitial IRT for resectable midface malignancies (2‐year relapse‐free survival = 82%, disease‐specific survival = 89%). Conclusion HDR IRT is a valuable tool in well‐defined clinical situations and, in particular, in recurrences. In midface malignancies, it could become the preferred primary treatment.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Group I: Exclusive Interstitial Brachytherapy In Recurrencmentioning

confidence: 99%

Section: Group Iii: Perioperative Interstitial Irt For Neck Recurrementioning

confidence: 99%

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HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

et al. 2019

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“…External beam radiation therapy extends survival in patients diagnosed with head and neck cancer; however, occurring xerostomia, dysphagia, impaired ability to sense taste, postradiation caries worsens the quality of life [35]. It is likely that delivering repeated external beam radiation therapy in patients diagnosed with head and neck cancer relapse would lead to higher frequency of late reactions.…”

Section: Reirradiation With Proton Beam Therapymentioning

confidence: 99%

Re-irradiation for Recurrent Head and Neck Cancer

Rudžianskas¹,

Kupčinskaitė-Noreikienė²

2017

Radiotherapy

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After radical treatment of head and neck cancer about 20-50% of patients are diagnosed with the locoregional recurrence during first two years. The main treatment for recurrent disease is salvage surgery, but in most cases, surgery is not feasible due to the high risk of complications and morbidity, and only 20% of patients are suitable for surgical salvage. Reirradiation is an effective treatment method with acceptable toxicity, but this treatment method is limited to normal tissue tolerance to a total dose. When chemotherapy is administered for recurrence, the response rate is up to 40%, so with the advancement of technical measures, after introduction of intensity-modulated radiotherapy, fractionated stereotactic body radiation therapy, high-dose-rate brachytherapy, proton beam reirradiation, a reirradiation is increasingly more often used for head and neck cancer relapse treatment. In this chapter, we will discuss about reirradiation with curative intent using new different radiation techniques (intensity-modulated radiotherapy (IMRT), stereotactic body radiation therapy (SBRT), high-dose-rate brachytherapy (HDR-BRT) and proton beam reirradiation (PBRT) for previously irradiated head and neck cancer and present recommendations for retreatment of head and neck cancer relapse using reirradiation alone or with systemic chemotherapy/biologic therapy.

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Fractionation Concepts

Nieder¹,

Baumann²

2016

Re-Irradiation: New Frontiers

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Reirradiation for patients with recurrence head and neck squamous cell carcinoma: A single-institution comparative study

Abstract: Following our results, we concluded that HDR-BRT is a more effective and safer treatment approach for head and neck cancer recurrences than 3D-CRT.

Cited by 22 publications

References 25 publications

HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

Re-irradiation for Recurrent Head and Neck Cancer

Fractionation Concepts

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