Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production

Poveda-Reyes, Sara; Mellera-Oglialoro, Leonardo Rubén; Martinez-Haya, R.; Gamboa-Martínez, Tatiana C.; Ribelles, J.L. Gómez; Ferrer, Gloria Gallego

doi:10.1002/mame.201500033

Cited by 24 publications

(23 citation statements)

References 61 publications

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“…Despite very good biological properties of gelatin, neat gelatin hydrogel cannot be used in biomedical applications without chemical cross‐linking due to its instability under physiological conditions and also poor mechanical properties. For this reason, some cross‐linking strategies have been introduced to construct gelatin hydrogel networks, so far . To the best of our knowledge, fabrication of a gelatin‐based dynamic hydrogel using a benzaldehyde derivative has not been reported yet.…”

Section: Introductionmentioning

confidence: 99%

Self‐Healing, Injectable Gelatin Hydrogels Cross‐Linked by Dynamic Schiff Base Linkages Support Cell Adhesion and Sustained Release of Antibacterial Drugs

Vahedi

Barzin

Shokrolahi

et al. 2018

Macro Materials & Eng

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A new class of dynamic hydrogels made through Schiff base bonds based on gelatin (type A and B) and polyethylene glycol dibenzaldehyde (diBA‐PEG, 2000 and 4000 g mol−1) is developed. Hydrogels form in situ by mixing aqueous solutions of gelatin and diBA‐PEG at a carefully adjusted pH. Compression test shows that the samples based on gelatin A are able to withstand at least ten cyclic loading/unloading without crack formation and significant permanent deformation. Self‐healing behavior of the hydrogel is proved by rheological measurements and also visual method. This hydrogel is proven to be injectable and nontoxic. Performance of the hydrogel in loading and delivery of clindamycin hydrochloride, as an antibacterial model drug, is evaluated against Staphylococcus aureus via antibacterial activity test. In vitro release of clindamycin hydrochloride is studied through an innovative method and it becomes clear that the release of clindamycin hydrochloride from this hydrogel follows a zero‐order kinetics.

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Section: Introductionmentioning

confidence: 99%

Self‐Healing, Injectable Gelatin Hydrogels Cross‐Linked by Dynamic Schiff Base Linkages Support Cell Adhesion and Sustained Release of Antibacterial Drugs

Vahedi

Barzin

Shokrolahi

et al. 2018

Macro Materials & Eng

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“…Equilibrium water content (EWC), mechanical properties, and the way the cells interact with these hydrogels are very different from those of injectable hydrogels. 24 Therefore, the results obtained on MSC differentiation in noninjectable hydrogels cannot be extrapolated to injectable hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Protein–Glycosaminoglycan Hydrogels Promote Chondrogenic Stem Cell Differentiation

et al. 2017

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Gelatin–hyaluronic acid (Gel–HA) hybrid hydrogels have been proposed as matrices for tissue engineering because of their ability to mimic the architecture of the extracellular matrix. Our aim was to explore whether tyramine conjugates of Gel and HA, producing injectable hydrogels, are able to induce a particular phenotype of encapsulated human mesenchymal stem cells without the need for growth factors. While pure Gel allowed good cell adhesion without remarkable differentiation and pure HA triggered chondrogenic differentiation without cell spreading, the hybrids, especially those rich in HA, promoted chondrogenic differentiation as well as cell proliferation and adhesion. Secretion of chondrogenic markers such as aggrecan, SOX-9, collagen type II, and glycosaminoglycans was observed, whereas osteogenic, myogenic, and adipogenic markers (RUNX2, sarcomeric myosin, and lipoproteinlipase, respectively) were not present after 2 weeks in the growth medium. The most promising matrix for chondrogenesis seems to be a mixture containing 70% HA and 30% Gel as it is the material with the best mechanical properties from all compositions tested here, and at the same time, it provides an environment suitable for balanced cell adhesion and chondrogenic differentiation. Thus, it represents a system that has a high potential to be used as the injectable material for cartilage regeneration therapies.

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“…As a result, a plethora of NC gels have been proposed to address challenges in tissue engineering and drug delivery, 8,13 -15 for instance for antimicrobial applications (with metal NPs), 16 controlled drug release, 17 regenerative medicine 9 (in particular with ceramic fillers, such as calcium phosphate), carbon-based nanomaterials 18 and biopolymers as the gel matrix. 8,19 Increasing activity has also been focused on 'smart' materials, and we show in this review that NC gels provide an ideal platform to impart responsiveness to soft materials.…”

Section: Introductionmentioning

confidence: 99%

Soft nanocomposites: nanoparticles to tune gel properties

Silva

Dreiss

2015

Polymer International

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The demand for new, soft materials with bespoke physical and biological characteristics and functionality has fuelled the research into nanocomposite hydrogels. 'Soft' nanocomposites -nanoparticles within a hydrated, polymeric gel matrix -offer a simple, yet versatile, platform for the design of materials with specific -and tunable -properties. Indeed, the 'soft' properties of the matrix can be combined with the inherent functionality of the nanoparticles (drug loading, antimicrobial, light refraction etc.) or give rise to altogether new characteristics (toughness, optical properties, self-healing etc.) evolved from the synergistic interaction of the polymer chains with the particles. In this review, we report the evolution and achievements of nanocomposite gels, with a focus on mechanisms and structure. The review is therefore structured around the properties resulting from the gel/nanoparticle association, rather than a classification based on applications or specific types of polymer or nanoparticles. How can nanoparticles tune mechanical, optical, biological properties or impart stimuli-responsiveness to a polymer gel matrix − and how is this behaviour linked to the underlying structure?

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Reinforcing an Injectable Gelatin Hydrogel with PLLA Microfibers: Two Routes for Short Fiber Production

Cited by 24 publications

References 61 publications

Self‐Healing, Injectable Gelatin Hydrogels Cross‐Linked by Dynamic Schiff Base Linkages Support Cell Adhesion and Sustained Release of Antibacterial Drugs

Self‐Healing, Injectable Gelatin Hydrogels Cross‐Linked by Dynamic Schiff Base Linkages Support Cell Adhesion and Sustained Release of Antibacterial Drugs

Hybrid Protein–Glycosaminoglycan Hydrogels Promote Chondrogenic Stem Cell Differentiation

Soft nanocomposites: nanoparticles to tune gel properties

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