Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid

Abstract

This is the author's final version of the contribution published as:

Development of bullous pemphigoid during nivolumab therapy

“…B regs express high levels of PD-L1 and can suppress humoral immune responses in a PD-1–dependent fashion 7 . B regs inhibit T-follicular helper cells and activate immunosuppressive T regulatory cells, 7 T-cell populations that seem to play a role in BP pathogenesis 8, 9…”

T regulatory cells and related immunoregulatory factors in polymorphic light eruption following ultraviolet A1 challenge

“…The disease occurs at all degrees of latitude, particularly affects the young female population and can significantly influence quality of life. [8][9][10][11][12][13][14] On the basis of the autoimmune-mediated pathogenesis of PLE proposed above, we aimed to investigate for the first time Tregs and related immunoregulatory factors in PLE lesions and controls. A delayed-type hypersensitivity reaction has been suggested in the pathogenesis of PLE, in which the normal UV-induced local immunosuppression appears to be absent.…”

A gene network bioinformatics analysis for pemphigoid autoimmune blistering diseases

“…Among the remaining interleukins, IL-10 was a potent antiinflammatory cytokine, able to inhibit the synthesis of several cytokines (IFNG, TNF, IL-3) and which, as reported in a previous study investigating different models of cellmediated immunity [35], might provide an interesting clue for a new therapeutic approach in the management of pemphigoid [36]. The presence of IL-17, able to differentiate naïve T-cells into respective effector helper T-cells (Th17), in the blister fluid, sera and conjunctiva of patients with ocular or bullous pemphigoid was verified [28,37]; moreover, the presence in the skin of IL-17 producing cells during exacerbation and their disappearance during remission was a strong indication of the pathogenic role played by the present interleukin [38].…”