2010
DOI: 10.1111/j.1600-0897.2010.00821.x
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Abstract: Citation Leber A, Teles A, Zenclussen AC. Regulatory T cells and their role in pregnancy. Am J Reprod Immunol 2010Regulatory T cells emerge in the last years as key players in allowing fetal survival within the maternal uterus. They were shown to be a unique subpopulation of T cells expanding during human and murine pregnancy. The importance of Treg for a normal pregnancy situation was proven by studies showing that their absence impairs murine pregnancy while the adoptive transfer of Treg prevents fetal rejec… Show more

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Cited by 144 publications
(122 citation statements)
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“…20 Since 1980, some groups have tried to identify expression of progesterone receptors during pregnancy, although with contradictory results. 21,22 Nevertheless, the gathering of scientific effort has enabled not only the presence of lymphocytic progesterone receptors 23 to be verified, but also validation of the existence of progesterone-induced blocking factor and its role in pregnancy.…”
Section: Discussionmentioning
confidence: 99%
“…20 Since 1980, some groups have tried to identify expression of progesterone receptors during pregnancy, although with contradictory results. 21,22 Nevertheless, the gathering of scientific effort has enabled not only the presence of lymphocytic progesterone receptors 23 to be verified, but also validation of the existence of progesterone-induced blocking factor and its role in pregnancy.…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence supports the concept that regulatory T cells (Tregs) play important roles in establishing and maintaining active immune tolerance during pregnancy (3,(5)(6)(7)(8). Tregs expand in the periphery and especially at the maternal-fetal interface in human and murine pregnancy (8). The proportion of systemic and decidual Tregs (dTregs) was significantly lower in specimens from women with recurrent miscarriages compared with that in specimens from women with a normal pregnancy (8).…”
mentioning
confidence: 93%
“…In addition, immunoregulatory molecules, including IDO, IL-10, and TGF-b, are expressed at high levels at the maternal-fetal interface. Accumulating evidence supports the concept that regulatory T cells (Tregs) play important roles in establishing and maintaining active immune tolerance during pregnancy (3,(5)(6)(7)(8). Tregs expand in the periphery and especially at the maternal-fetal interface in human and murine pregnancy (8).…”
mentioning
confidence: 96%
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“…Theoretically, one could consider T reg induction in the treatment of autoimmunity (Kim et al, 2007), to establish tolerance to a transplanted organ (Boros and Bromberg, 2009), or in the treatment of spontaneous abortions (Leber et al, 2010). In this case, potential side effects could include increased risk of infection or cancer associated with impaired immunosurveillance.…”
Section: Implications Of T Reg Therapy In the Treatment Of Immunologimentioning
confidence: 99%