Biochemical Pharmacology volume 77, issue 1, P101-113 2009 DOI: 10.1016/j.bcp.2008.09.021 View full text
Rajakrishnan Veluthakal, Suresh Vasu Madathilparambil, Phillip McDonald, Lawrence Karl Olson, Anjaneyulu Kowluru

Abstract: AbstractUsing various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion [GSIS]. However, little is understood with respect to localization of, and regulation by, specific regulatory factors of Rac1 in GSIS. Herein, we investigated regulatory roles for Tiam1, a specific nucleotide exchange factor [GEF] for Rac1, in GSIS in pancreatic β-cells. Western blot analysis indicated that Tiam…

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