Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review

Alizamini, Mirmohammadali Mirramezani; Fattahi, Mojdeh; Sayehmiri, Fatemeh; Haghparast, Abbas; Liang, Jing

doi:10.1007/s10571-022-01289-2

Cited by 3 publications

(2 citation statements)

References 78 publications

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“… 50 In addition, GCs upregulate CRH in the amygdala, frontal cortex, and bed nucleus of the stria terminalis, while downregulating CRH in the hypothalamus, leading to differential expression of cortisol and CRH and consequently to different anxiety symptoms. 51 CRH has been shown to be associated with the encoding of anxiety and emotional memory, 52 , 53 emphasizing the critical role of CRH in the stress response, while neuronal circuits of CRH in the central amygdala can interact with the 5-HT and noradrenergic systems, both of which are closely associated with anxiety and depression disorders. 52 …”

Section: The Hpa Axis In Endocrine Factorsmentioning

confidence: 99%

New Insights into the Mutual Promotion of Rosacea, Anxiety, and Depression from Neuroendocrine Immune Aspects

Yang¹,

Cai²

2023

CCID

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Rosacea is a common chronic inflammatory skin disease with a complex etiology and undefined pathogenesis, and there is still a lack of targeted clinical treatment. Patients with rosacea are at a higher risk of anxiety and depression compared to the healthy population. Compared to skin conditions such as acne and psoriasis, rosacea has been much less studied in relation to multiple-etiology psychiatric disorders such as anxiety and depression. In contrast to the mainstream belief that the causal association between rosacea and psychiatric disorders is that rosacea increases the psychological burden of patients and thus triggers psychiatric disorders simply by altering their facial appearance, this review outlines the possible common mechanisms between rosacea and anxiety and depression disorders, starting from the pathophysiological mechanisms of transient receptor potential family cation channels, HPA axis, and Th1/Th17 cell polarization. It envisages the possibility of the neuroendocrine-immune interplay between rosacea and anxiety and depression, and new ideas on the complex causal relationship between rosacea and psychiatric disorders, offering more orientations to open up new therapeutic approaches for rosacea.

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Section: The Hpa Axis In Endocrine Factorsmentioning

confidence: 99%

New Insights into the Mutual Promotion of Rosacea, Anxiety, and Depression from Neuroendocrine Immune Aspects

Yang¹,

Cai²

2023

CCID

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“…(12) Algunos de estos estudios relatan que tres meses antes de los exámenes, los sujetos ya empezaron a notar ciertos síntomas psicosomáticos (dolor de estómago, sensación general de cansancio…) y se produjo un incremento en el consumo de tranquilizantes y somníferos. (13) El fin de semana previo, la sintomatología psicosomática aumenta de sobremanera en magnitud, y variabilidad e incluso algunos estudiantes cayeron enfermos, debido probablemente a un estado de mayor vulnerabilidad. Por último, la mañana en que comenzaban los exámenes, la mayoría de los estudiantes dijo sufrir dolor de estómago, diarrea e intolerancia al desayuno.…”

Section: Introductionunclassified

Academic stress in first year students in the career of Medical Surgeon of the Facultad de Estudios Superiores Zaragoza. UNAM, 2022

Arellano,

Arlen Pineda,

Luisa

et al. 2023

Seminars in Medical Writing and Education

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Introduction: A descriptive and exploratory non-experimental study was carried out with the purpose of knowing the characteristics of academic stress generated in Medicine students in the fourth module of the first year in the 2022 generation of the degree in Medical Surgeon of the Facultad de Estudios Superiores (FES) Zaragoza, to determine which are the most relevant factors of academic stress. Methods: The sample consisted of 200 students of the FES Zaragoza (UNAM). The Systematic Inventory of Academic Stress (SISCO) was used to obtain the data. Results: It was found that the environmental stimuli most frequently identified as stressors were work overload, teacher evaluations, as well as the character and personality of the teachers. The most frequent stress indicators are sleep disorders, chronic fatigue, and drowsiness. Being thus the most frequently used coping strategies, assertive ability, elaboration of a plan and execution of their tasks as well as self-praise. Conclusions: It can be concluded that there are differences in the frequency of presentation of the characteristics of academic stress, the importance of these is highlighted, since this will allow implementing some solutions such as the design and implementation of workshops or programs for better stress management in the academic environment with this type of population.

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Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained, sex-specific changes in behavioral plasticity and the transcriptomic profile of the amygdala

Martz,

Shelton,

Langen

et al. 2024

Preprint

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Peripuberty is a significant period of neurodevelopment with long-lasting effects on the brain and behavior. Blocking type 1 corticotropin-releasing factor receptors (CRFR1) in neonatal and peripubertal rats attenuates detrimental effects of early-life stress on neural plasticity, behavior, and stress hormone action, long after exposure to the drug has ended. CRFR1 antagonism can also impact neural and behavioral development in the absence of stressful stimuli, suggesting sustained alterations under baseline conditions. To investigate this further, we administered a CRFR1 antagonist (CRFR1a), R121919, to young adolescent male and female rats across 4 days. Following each treatment, rats were tested for locomotion, social behavior, mechanical allodynia, or PPI of the acoustic startle reflex. Acute CRFR1 blockade immediately reduced PPI in peripubertal males, but not females. In adulthood, each assay was repeated without CRFR1a exposure to test for long-term effects of the adolescent treatment, with males continuing to experience deficits in PPI, while females displayed altered locomotion, PPI, and social behavior. The amygdala was collected to measure long-term effects on gene expression in pathways related to neural plasticity and neurodevelopmental disorders. Relative expression of cannabinoid type 1 receptors (CB1R), which mediate sensorimotor and HPA function, was also measured. In the adult amygdala, peripubertal CRFR1a induced alterations in pathways related to neural plasticity and stress in males and lower expression of CB1R protein in females. Understanding how acute exposure to neuropharmacological agents can have sustained impacts on brain and behavior, in the absence of further exposures, has important clinical implications for adolescent psychiatric treatment protocols.

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Regulatory Role of PFC Corticotropin-Releasing Factor System in Stress-Associated Depression Disorders: A Systematic Review

Cited by 3 publications

References 78 publications

New Insights into the Mutual Promotion of Rosacea, Anxiety, and Depression from Neuroendocrine Immune Aspects

New Insights into the Mutual Promotion of Rosacea, Anxiety, and Depression from Neuroendocrine Immune Aspects

Academic stress in first year students in the career of Medical Surgeon of the Facultad de Estudios Superiores Zaragoza. UNAM, 2022

Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained, sex-specific changes in behavioral plasticity and the transcriptomic profile of the amygdala

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