“…Knowledge about the binding profiles of nucleic acid-binding proteins (NBPs) is a vital prerequisite to detecting potential NBP binding targets (i.e. RNAs and DNAs) in the cell, and understanding gene regulation and evolution ( Dong et al , 2018 ; Tak Leung et al , 2019 ; Yang et al , 2011 ). Currently, the binding profiles are mainly determined computationally ( Lambert et al , 2018 ; Pan et al , 2019 ) from high-throughput experimental data such as protein-binding microarray (PBM) ( Berger et al , 2006 ; Weirauch et al , 2014 ) or chromatin immunoprecipitation (ChIP)-seq ( Barski and Zhao, 2009 ; Park, 2009 ) for transcription factors (TFs), and RNAcompete assay ( Ray et al , 2009 , 2013 ) or crosslinking immunoprecipitation (CLIP) ( Konig et al , 2012 ; Wang et al , 2015 ) for RNA-binding proteins (RBPs).…”