2018
DOI: 10.18632/aging.101485
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Abstract: Dysregulation of mRNA splicing has been observed in certain cellular senescence process. However, the common splicing alterations on the whole transcriptome shared by various types of senescence are poorly understood. In order to systematically identify senescence-associated transcriptomic changes in genome-wide scale, we collected RNA sequencing datasets of different human cell types with a variety of senescence-inducing methods from public databases and performed meta-analysis. First, we discovered that a gr… Show more

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Cited by 9 publications
(7 citation statements)
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References 57 publications
(75 reference statements)
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“…Many lncRNAs can regulate the expression of downstream target genes by forming complexes with RNA‐binding proteins, then acts as an oncogene or a suppressor oncogene . In this study, we found that knockdown of MAPKAPK5‐AS1 in CRC cells could lead to changes in related downstream genes, including p15 , p21 , p27 , p57 , KLF2 , and Trail .…”
Section: Discussionmentioning
confidence: 64%
See 1 more Smart Citation
“…Many lncRNAs can regulate the expression of downstream target genes by forming complexes with RNA‐binding proteins, then acts as an oncogene or a suppressor oncogene . In this study, we found that knockdown of MAPKAPK5‐AS1 in CRC cells could lead to changes in related downstream genes, including p15 , p21 , p27 , p57 , KLF2 , and Trail .…”
Section: Discussionmentioning
confidence: 64%
“…26 Therefore, the discovery of new CRC-related lncRNAs is of great significance for further understanding the molecular mechanisms of CRC progression and providing clinical therapeutic targets. In this study, we analyzed 2 sources Many lncRNAs can regulate the expression of downstream target genes by forming complexes with RNA-binding proteins, [27][28][29][30] then acts as an oncogene or a suppressor oncogene. [31][32][33][34][35] In this study, we found that knockdown of MAPKAPK5-AS1 in CRC cells could lead to changes in related downstream genes, including p15, p21, p27, p57, KLF2, and Trail.…”
Section: Discussionmentioning
confidence: 99%
“…Altered senescence‐induced expression patterns of key SF families suggested a loss of AS regulation complexity with senescence (Holly et al, 2013). Moreover, numerous RNA‐binding proteins are downregulated upon senescence induction, and multiple differentially spliced events were shared between distinct pathways that induce senescence in human cells (Dong et al, 2018). Interestingly, many of the AS events occurred in genes associated with RNA splicing or the spliceosome itself.…”
Section: Hallmarks Of Aging and Splicingmentioning
confidence: 99%
“…Interestingly, many of the AS events occurred in genes associated with RNA splicing or the spliceosome itself. Combining differential gene expression data and binding motif data surrounding the differentially spliced genes, SFs SRSF1 , SRSF7 , QKI , RBFOX2 , PTBP1 , HNRNPK , HNRNPM , and HNRNPUL1 , were predicted as key regulators of senescence‐associated AS events (Dong et al, 2018). Similarly, senescent neuroblastoma cells were shown to suppress expression of SRSF7 (Kadota et al, 2020).…”
Section: Hallmarks Of Aging and Splicingmentioning
confidence: 99%
“…Knowledge about the binding profiles of nucleic acid-binding proteins (NBPs) is a vital prerequisite to detecting potential NBP binding targets (i.e. RNAs and DNAs) in the cell, and understanding gene regulation and evolution ( Dong et al , 2018 ; Tak Leung et al , 2019 ; Yang et al , 2011 ). Currently, the binding profiles are mainly determined computationally ( Lambert et al , 2018 ; Pan et al , 2019 ) from high-throughput experimental data such as protein-binding microarray (PBM) ( Berger et al , 2006 ; Weirauch et al , 2014 ) or chromatin immunoprecipitation (ChIP)-seq ( Barski and Zhao, 2009 ; Park, 2009 ) for transcription factors (TFs), and RNAcompete assay ( Ray et al , 2009 , 2013 ) or crosslinking immunoprecipitation (CLIP) ( Konig et al , 2012 ; Wang et al , 2015 ) for RNA-binding proteins (RBPs).…”
Section: Introductionmentioning
confidence: 99%