“…The keen reader will definitely study the chart for her-or himself, however, suffice to emphasize that there are the biological pathways or cellular functions on which receptors PXR/RXR and LXR/RXR exert powerful biological impacts: metabolism in general, cell proliferation, lipogenesis, lipolysis, cholesterol metabolism, carbohydrate metabolism, steroid metabolism, feedback inhibition of T3 and T4, muscle contraction, coagulation, thermogenesis, cell communication, sperm function, exocytosis, cell cycle regulation, and CNS function [14]. On the right-hand figure, the reader can observe that the PI3K-AKT signalling pathway, used by both osteoblasts or fibroblasts/HUVEC/VIC cell phenotypes to ensure or block the development of mineralizing properties [1], or described as modulators of GSK3, Bcl-2, RXRα and NFκB, and the FOXO-family of transcription factors, which are involved in biological phenomena summarized as glycolysis/gluconeogenesis, cell cycle, apoptosis, and NFκB/p53-signalling, of which all of them can and should be construed as adaptors of cell 'lifetime' = survival and 'phenotype' = functional stabilization [14].…”