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Cited by 2 publications
(4 citation statements)
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References 111 publications
(162 reference statements)
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“…The keen reader will definitely study the chart for her-or himself, however, suffice to emphasize that there are the biological pathways or cellular functions on which receptors PXR/RXR and LXR/RXR exert powerful biological impacts: metabolism in general, cell proliferation, lipogenesis, lipolysis, cholesterol metabolism, carbohydrate metabolism, steroid metabolism, feedback inhibition of T3 and T4, muscle contraction, coagulation, thermogenesis, cell communication, sperm function, exocytosis, cell cycle regulation, and CNS function [14]. On the right-hand figure, the reader can observe that the PI3K-AKT signalling pathway, used by both osteoblasts or fibroblasts/HUVEC/VIC cell phenotypes to ensure or block the development of mineralizing properties [1], or described as modulators of GSK3, Bcl-2, RXRα and NFκB, and the FOXO-family of transcription factors, which are involved in biological phenomena summarized as glycolysis/gluconeogenesis, cell cycle, apoptosis, and NFκB/p53-signalling, of which all of them can and should be construed as adaptors of cell 'lifetime' = survival and 'phenotype' = functional stabilization [14].…”
Section: Vitamin K2 -Vital For Health and Wellbeingmentioning
confidence: 99%
See 1 more Smart Citation
“…The keen reader will definitely study the chart for her-or himself, however, suffice to emphasize that there are the biological pathways or cellular functions on which receptors PXR/RXR and LXR/RXR exert powerful biological impacts: metabolism in general, cell proliferation, lipogenesis, lipolysis, cholesterol metabolism, carbohydrate metabolism, steroid metabolism, feedback inhibition of T3 and T4, muscle contraction, coagulation, thermogenesis, cell communication, sperm function, exocytosis, cell cycle regulation, and CNS function [14]. On the right-hand figure, the reader can observe that the PI3K-AKT signalling pathway, used by both osteoblasts or fibroblasts/HUVEC/VIC cell phenotypes to ensure or block the development of mineralizing properties [1], or described as modulators of GSK3, Bcl-2, RXRα and NFκB, and the FOXO-family of transcription factors, which are involved in biological phenomena summarized as glycolysis/gluconeogenesis, cell cycle, apoptosis, and NFκB/p53-signalling, of which all of them can and should be construed as adaptors of cell 'lifetime' = survival and 'phenotype' = functional stabilization [14].…”
Section: Vitamin K2 -Vital For Health and Wellbeingmentioning
confidence: 99%
“…A short and non-exhaustive summary (for details, see above) of the potential biological impact exerted by MK-7 is quite impressive, and encompasses phenomena like the regulation of: protein synthesis, the cell cycle, cell survival, cell adhesion, nuclear transport, DNA replication and repair, cell phenotype regulation and stabilization via impact on histone deacetylases (HDACs), as well as inflammatory processes [1]. As seen from the few genes described above, it may be asserted that vitamin K2 is also able to influence bodily phenomena like energy (lipid and glucose) metabolism, due to a balance between the amount of bodily distribution of white and brown/beige adipocyte phenotypes.…”
Section: )mentioning
confidence: 99%
“…It is well known that the osteoblast and odontoblast phenotypes are "determined" and "stabilized" by the RUNX-and SP-families of transcription factors (upregulated), as well as the microRNA-species 149, 328, and 339 (downregulated). Recently, it was shown [58] that mir-760 is involved in the effect of vitamin K2, since it associates with the transcription factor NR1/2 = SXR = PXR [65].…”
Section: Major Findingsmentioning
confidence: 99%
“…Recently, studies have shown that Osterix (Osx), serving as an important transcriptional factor, along with Runx1, Runx2, SP1, and SP3 [58], all participating in osteogenesis and odontogenesis, is thought to play a vital role underlying the mechanisms that determine the developmental differences between the root and the crown. During tooth development, Osx, particularly in odontoblasts and cementoblasts, promote and sustain their differentiation as well as and mineralization.…”
Section: +mentioning
confidence: 99%