Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury

Cao, Qi; Wang, Ruifeng; Wang, Yiping; Niu, Zhiguo; Chen, Titi; Wang, Chengshi; Jin, Li; Huang, Qingsong; Li, Qing; Wang, Xin Maggie; Azmi, Farhana; Lee, Vincent; Wang, Yuan Min; Zheng, Guoping; Alexander, Stephen I.; Harris, David C.H.

doi:10.1016/j.kint.2019.07.019

Cited by 31 publications

(31 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They express some specific genes such as id2, id3, sox4, tgfbr1, tgfbr2, il2rb, and il2rg, and continue expressing specific cytokines such as IL-10 and TGF-b1 [4][5][6]. More studies had been demonstrated the important roles that this subpopulation cells played in different patients [7][8][9]14]. Our previous study results demonstrated deficient regulatory innate lymphoid cells and differential expression of miRNAs in acute myeloid leukemia [7].…”

Section: Discussionmentioning

confidence: 83%

See 1 more Smart Citation

Decreased bone marrow regulatory innate lymphoid cells show a distinctive miRNA profiling in aplastic anemia

Wan

Guo

et al. 2020

Hematology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 83%

“…These ILCregs express specific genes such as id2, id3, sox4, tgfbr1, tgfbr2, il2rb, and il2rg and express specific cytokines such as IL-10 and TGF-β1 [4][5][6]. After the identification of the ILCregs, new studies had been reported by different groups [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Decreased bone marrow regulatory innate lymphoid cells show a distinctive miRNA profiling in aplastic anemia

Wan

Guo

et al. 2020

Hematology

View full text Add to dashboard Cite

“…Here, we identified two subsets of ILC2s in islet graft and kidney of islet transplant mice treated with IL‐33, ILC2 10 , and non‐IL‐10 producing ILC2s (Fig 5A and B). The IL‐2/anti‐IL‐2 antibody complex (IL‐2C) has been found to directly induce expansion of ILC2 that express the high‐affinity IL‐2 receptor CD25 (Seehus et al , 2017; Cao et al , 2020). Using IL‐10 reporter mice, we further demonstrated that combined IL‐33 and IL‐2C treatment markedly enhanced the ILC2 10 expansion in the kidney when compared with IL‐33 treatment alone (Fig 5C).…”

Section: Resultsmentioning

confidence: 99%

IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival

Huang

Wang

et al. 2020

EMBO Mol Med

Self Cite

View full text Add to dashboard Cite

Type 2 innate lymphoid cells (ILC2s) are a subset of ILCs with critical roles in immunoregulation. However, the possible role of ILC2s as immunotherapy against allograft rejection remains unclear. Here, we show that IL‐33 significantly prolonged islet allograft survival. IL‐33‐treated mice had elevated numbers of ILC2s and regulatory T cells (Tregs). Depletion of Tregs partially abolished the protective effect of IL‐33 on allograft survival, and additional ILC2 depletion in Treg‐depleted DEREG mice completely abolished the protective effects of IL‐33, indicating that ILC2s play critical roles in IL‐33‐mediated islet graft protection. Two subsets of ILC2s were identified in islet allografts of IL‐33‐treated mice: IL‐10 producing ILC2s (ILC210) and non‐IL‐10 producing ILC2s (non‐ILC10). Intravenous transfer of ILC210 cells, but not non‐ILC10, prolonged islet allograft survival in an IL‐10‐dependent manner. Locally transferred ILC210 cells led to long‐term islet graft survival, suggesting that ILC210 cells are required within the allograft for maximal suppressive effect and graft protection. This study has uncovered a major protective role of ILC210 in islet transplantation which could be potentiated as a therapeutic strategy.

show abstract

“…These results demonstrated that regulatory innate lymphocytes inhibit the inflammation and ischemia / reperfusion injury of the kidney. 11 Another study has found that retinoic acid induced IL-10 secretion by human ILC2s but not type 2 cytokines. IL-10+ ILCregs, which were converted from ILC2s by means of retinoic acid stimulation, expressed a regulatory T cell-like signature with expression of IL-10, cytotoxic T lymphocyteassociated protein 4, and CD25, with down regulated effector type 2-related markers, such as chemoattractant receptor-homologous molecule on TH2 cells and ST2, and suppressed activation of CD41 T cells and ILC2s.…”

Section: Ilcregs: To Be or Not To Bementioning

confidence: 99%

Regulatory Innate Lymphoid Cells: A new subset of innate immune lymphocytes with more potential functions to be discovered in immune regulation

Cao

et al. 2020

J Current Med Res Opinion

View full text Add to dashboard Cite

Regulatory innate lymphoid cells (ILCregs) are a newly identified subset of innate immune lymphocytes. The discovery of this subset cell has revealed several inhibitory and stimulatory pathways that affect the regulatory functions of ILCregs, in addition to miRNA and other genetic molecular regulations. These pathways may play important roles in the pathogenesis and potential immunotherapy in patients with different kind of diseases, such as inflammation and ischemia / reperfusion injury of the kidney, acute myeloid leukemia, through immunomodulatory and anti-inflammatory pathway, as well as miRNA regulations. Further studies on ILCregs may be a potentially high interest in the near future.

show abstract

Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury

Cited by 31 publications

References 40 publications

Decreased bone marrow regulatory innate lymphoid cells show a distinctive miRNA profiling in aplastic anemia

Decreased bone marrow regulatory innate lymphoid cells show a distinctive miRNA profiling in aplastic anemia

IL ‐10 producing type 2 innate lymphoid cells prolong islet allograft survival

Regulatory Innate Lymphoid Cells: A new subset of innate immune lymphocytes with more potential functions to be discovered in immune regulation

Contact Info

Product

Resources

About