J. Biochem. Mol. Toxicol.
 1998
DOI: 10.1002/(sici)1099-0461(1998)12:1<3::aid-jbt2>3.0.co;2-p
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Regulatory DNA elements of phenobarbital-responsive cytochrome P450 CYP2B genes

Paavo Honkakoski
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Masahiko Negishi
2
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Cited by 69 publications

(35 citation statements)
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“…None of the enzymes induced in the liver (CYP3A9, EPHX1, UGT2B1, or MRP3) were modulated by PB in the OM. This finding could be due to the absence of CAR expression in this tissue, because it is well known that CAR regulates the gene expression of the enzymes induced by PB (Honkakoski and Negishi, 1998). These observations are in keeping with previous reports that showed low effects of PB in the OM (Longo et al, 1988).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…None of the enzymes induced in the liver (CYP3A9, EPHX1, UGT2B1, or MRP3) were modulated by PB in the OM. This finding could be due to the absence of CAR expression in this tissue, because it is well known that CAR regulates the gene expression of the enzymes induced by PB (Honkakoski and Negishi, 1998). These observations are in keeping with previous reports that showed low effects of PB in the OM (Longo et al, 1988).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The most logical explanation for the lack of increased CYP2B10 would be that CAR-mediated signaling is altered in the absence of PPAR␤/␦ expression, because it is known that CYP2B10 is regulated by CAR. 49,50 However, administration of a CAR ligand caused up-regulation of CYP2B10 in both wild-type and PPAR␤/␦-null mice, and expression of mRNA encoding CAR is also not different between genotypes (data not shown). Furthermore, administration of a PPAR␤/␦ ligand does not increase CYP2B10 expression in liver, indicating that CYP2B10 is not directly regulated by PPAR␤/␦.…”
Section: Discussionmentioning
confidence: 90%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A related CYP2B gene, the mouse Cyp2b9 gene, is not PB inducible. The sequence of this gene corresponding to PBREM had diverged, resulting in a nonfunctional PBREM element (8,9). Moreover, the mutated NR1 sequence (NR1*) of the Cyp2b9 gene did not compete with the functional NR1 for binding to nuclear proteins.…”
Section: Resultsmentioning
confidence: 99%
“…PB alone can induce the genes encoding CYP, NADPH-CYP reductase, and different transferases involved in conjugation reactions, in addition to many other genes (9,24). We have now identified the nuclear orphan receptors CAR and RXR as factors regulating the transcription of the PBinducible Cyp2b10 genes.…”
Section: Discussionmentioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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