Biochemical Pharmacology volume 78, issue 10, P1289-1297 2009 DOI: 10.1016/j.bcp.2009.06.028 View full text
Jillian H. Hurst, Shelley B. Hooks

Abstract: The regulator of G-protein signaling (RGS) family is a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). In recent years, GPCRs have been linked to the initiation and progression of multiple cancers; thus, regulators of GPCR signaling are also likely to be important to the pathophysiology of cancer. This review highlights recent studies detailing changes in RGS transcript expression during oncogenesis, single nucleotide polymorp…

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