Regulation of Vascular Endothelial Growth Factor by Oxygen in a Model of Retinopathy of Prematurity

Increased Angiogenic Factors Associated With Peripheral Avascular Retina and Intravitreous Neovascularization

“…However, we found that VEGF 164 expression increased with an almost 10-fold change between p0 and p14 in the 50/10 OIR model and this represented a 3-fold increase in expression compared to room air (Figure 3). This finding also contrasts with reports using the mouse oxygen-induced retinopathy model, in which VEGF expression was lower than room air during the phase of hyperoxia induced vaso-obliteration 15 .…”

Increased Angiogenic Factors Associated With Peripheral Avascular Retina and Intravitreous Neovascularization

“…However, we found that VEGF 164 expression increased with an almost 10-fold change between p0 and p14 in the 50/10 OIR model and this represented a 3-fold increase in expression compared to room air (Figure 3). This finding also contrasts with reports using the mouse oxygen-induced retinopathy model, in which VEGF expression was lower than room air during the phase of hyperoxia induced vaso-obliteration 15 .…”

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

“…Since DDAH2 can induce expression of vascular endothelial growth factor (VEGF) in cultured endothelial cell ( Hasegawa et al., 2006 ), which is well recognized for its pro-angiogenic role in OIR ( Aiello et al., 1995 ), we investigated retinal VEGF protein levels in DDAH2 -deficient mice during OIR. The concentration of VEGF protein was significantly raised in the retina during the hypoxic phase of OIR, a finding that is consistent with previous reports ( Pierce et al., 1996 ). We could recently show that VEGF is expressed in the ganglion cell layer, the inner nuclear layer and the retinal pigmented epithelium upon OIR induction ( Liyanage et al., 2016 ).…”

Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy

“…2, P10). These findings are in accordance with those of Pierce and colleagues (Pierce et al. 1996) and confirm the well‐described role of this growth factor in hypoxia‐driven, VEGF‐mediated retinal angiogenesis during physiological development.…”

Increased Angiogenic Factors Associated With Peripheral Avascular Retina and Intravitreous Neovascularization

“…However, we found that VEGF 164 expression increased with an almost 10-fold change between p0 and p14 in the 50/10 OIR model and this represented a 3-fold increase in expression compared to room air (Figure 3). This finding also contrasts with reports using the mouse oxygen-induced retinopathy model, in which VEGF expression was lower than room air during the phase of hyperoxia induced vaso-obliteration 15 .…”

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

“…Since DDAH2 can induce expression of vascular endothelial growth factor (VEGF) in cultured endothelial cell ( Hasegawa et al., 2006 ), which is well recognized for its pro-angiogenic role in OIR ( Aiello et al., 1995 ), we investigated retinal VEGF protein levels in DDAH2 -deficient mice during OIR. The concentration of VEGF protein was significantly raised in the retina during the hypoxic phase of OIR, a finding that is consistent with previous reports ( Pierce et al., 1996 ). We could recently show that VEGF is expressed in the ganglion cell layer, the inner nuclear layer and the retinal pigmented epithelium upon OIR induction ( Liyanage et al., 2016 ).…”

Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy

“…2, P10). These findings are in accordance with those of Pierce and colleagues (Pierce et al. 1996) and confirm the well‐described role of this growth factor in hypoxia‐driven, VEGF‐mediated retinal angiogenesis during physiological development.…”

Increased Angiogenic Factors Associated With Peripheral Avascular Retina and Intravitreous Neovascularization

“…However, we found that VEGF 164 expression increased with an almost 10-fold change between p0 and p14 in the 50/10 OIR model and this represented a 3-fold increase in expression compared to room air (Figure 3). This finding also contrasts with reports using the mouse oxygen-induced retinopathy model, in which VEGF expression was lower than room air during the phase of hyperoxia induced vaso-obliteration 15 .…”

Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis

“…Since DDAH2 can induce expression of vascular endothelial growth factor (VEGF) in cultured endothelial cell ( Hasegawa et al., 2006 ), which is well recognized for its pro-angiogenic role in OIR ( Aiello et al., 1995 ), we investigated retinal VEGF protein levels in DDAH2 -deficient mice during OIR. The concentration of VEGF protein was significantly raised in the retina during the hypoxic phase of OIR, a finding that is consistent with previous reports ( Pierce et al., 1996 ). We could recently show that VEGF is expressed in the ganglion cell layer, the inner nuclear layer and the retinal pigmented epithelium upon OIR induction ( Liyanage et al., 2016 ).…”

Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy

“…2, P10). These findings are in accordance with those of Pierce and colleagues (Pierce et al. 1996) and confirm the well‐described role of this growth factor in hypoxia‐driven, VEGF‐mediated retinal angiogenesis during physiological development.…”