Regulation of transcriptional network system during bone and cartilage development

Nishimura, Riko; Hata, Kenji; Ikeda, Fumiyo; Matsubara, Takuma; Amano, Katsuhiko; Ono, Kazuhisa; Takigawa, Yoko; Takashima, Rikako; Yoshida, Michiko; Nakamura, Eriko; Yoneda, Toshiyuki

doi:10.1016/j.job.2015.06.001

Cited by 2 publications

(2 citation statements)

References 91 publications

(119 reference statements)

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“…Extracellular matrix composition is similar in bone and teeth, so they share many of the same genes and hormones for their development. For example, signaling pathways involving WNT, fibroblast growth factors (FGFs), bone morphogenetic protein (BMP), sonic hedgehog (SHH) and ectodysplasin (EDA) are required for both tooth and endochondral bone development, and share transcription factors such as Pax9 and Runx2 [ [21] , [22] , [23] , [24] , [25] ]. Parathyroid hormone (PTH), PTH-related protein (PTHrP) and PTH-1 receptor (PTH1R) are known for their importance in root formation and eruption [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum

Yagasaki,

Chiba,

Kurimoto

et al. 2024

Regenerative Therapy

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Section: Discussionmentioning

confidence: 99%

The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum

Yagasaki,

Chiba,

Kurimoto

et al. 2024

Regenerative Therapy

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“…H3K4me3 and histone 3 lysine 27 acetylation (H3K27ac) are enriched in highly expressed genes, while H3K27me3 shows a greater enrichment in genes with low expression levels in different developmental stages of chondrocyte. Histone modifications around the enhancer and promoter of the key chondrocyte marker genes SOX9 and collagen type II (COL2A1) switch from repression in human MSCs to transcriptionally active in differentiated chondrocytes (Wang et al, 2012;Nishimura et al, 2013;Cheung et al, 2020). Therefore, a comprehensive understanding of the histone modifications associated with cartilage development and…”

Section: Introductionmentioning

confidence: 99%

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

Wan

Zhang

Yao

et al. 2021

Front. Cell Dev. Biol.

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The involvement of histone modifications in cartilage development, pathology and regeneration is becoming increasingly evident. Understanding the molecular mechanisms and consequences of histone modification enzymes in cartilage development, homeostasis and pathology provides fundamental and precise perspectives to interpret the biological behavior of chondrocytes during skeletal development and the pathogenesis of various cartilage related diseases. Candidate molecules or drugs that target histone modifying proteins have shown promising therapeutic potential in the treatment of cartilage lesions associated with joint degeneration and other chondropathies. In this review, we summarized the advances in the understanding of histone modifications in the regulation of chondrocyte fate, cartilage development and pathology, particularly the molecular writers, erasers and readers involved. In addition, we have highlighted recent studies on the use of small molecules and drugs to manipulate histone signals to regulate chondrocyte functions or treat cartilage lesions, in particular osteoarthritis (OA), and discussed their potential therapeutic benefits and limitations in preventing articular cartilage degeneration or promoting its repair or regeneration.

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Regulation of transcriptional network system during bone and cartilage development

Cited by 2 publications

References 91 publications

The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum

The essential role of Mkx in periodontal ligament on the metabolism of alveolar bone and cementum

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic Implications

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