Regulation of the Immune Response in Neonatal Piglets by Maternal Antibody

Muscoplat, Charles C; Setcavage, Thomas M.; Kim, Yoon B.

doi:10.1159/000231820

Cited by 16 publications

(6 citation statements)

References 12 publications

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“…The suppression of IgE responsiveness is noteworthy (Bednar-Tantscher et al, 2001;Jarret and Hall, 1979;Roberts and Turner, 1983), which might explain the delayed onset of atopy among breastfed infants (Halpern et al, 1973). Suppression in newborn artiodactyls has also been shown (Hammerberg et al, 1989;Hoerlein, 1957;Husband and Lascelles, 1975;Klobasa et al, 1981Klobasa et al, , 1986Logan et al, 1974;Muscoplat et al, 1977). In piglets reared in an autosow, ingestion of 3.5 g purified IgG suppresses de novo synthesis of IgG and IgA to the same extent as colostrum .…”

Section: Immunomodulation By Passive Igs and Antibodiesmentioning

confidence: 99%

The Mammary Gland in Mucosal and Regional Immunity

et al. 2015

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Section: Immunomodulation By Passive Igs and Antibodiesmentioning

confidence: 99%

The Mammary Gland in Mucosal and Regional Immunity

et al. 2015

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“…Maternal antibodies do not only confer passive protection, but may in addition influence the developing immune system of the newborn in such a way that antigen‐induced immune responses may seemingly be suppressed or can be enhanced. Since the 1940s until present, it has been reported that antibody responses at an early age in the offspring of immunized mothers are suppressed and that this suppression is mediated by passively acquired maternal antibodies [ 30–36]. However, this suppression is transient in nature and affects apparently mainly the antibody response [ 31, 33, 37], while for instance the generation of delayed type hypersensitivity (DTH) effector cells and memory cells is not impaired, thus enabling normal secondary responses [ 38].…”

Section: Maternal Immunization Confers More Than Passive Protection Onlymentioning

confidence: 99%

“…Since the 1940s until present, it has been reported that antibody responses at an early age in the offspring of immunized mothers are suppressed and that this suppression is mediated by passively acquired maternal antibodies [ 30–36]. However, this suppression is transient in nature and affects apparently mainly the antibody response [ 31, 33, 37], while for instance the generation of delayed type hypersensitivity (DTH) effector cells and memory cells is not impaired, thus enabling normal secondary responses [ 38]. Consequently, this misleading suppression mediated by the maternal antibodies can be overcome by a second immunization [ 39] or by increasing the antigen dose of the primary vaccination [ 40].…”

Section: Maternal Immunization Confers More Than Passive Protection Onlymentioning

confidence: 99%

Is There a Maternally Induced Immunological Imprinting Phase à la Konrad Lorenz?

Lemke

Lange

1999

Scand J Immunol

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Lemke H, Lange H. Is There a Maternally Induced Immunological Imprinting a Á la Konrad Lorenz? Scand J Immunol 1999;50:348±354 In mammals, IgG antibodies are transferred from mothers to the offspring. Since these maternal antibodies result mainly from thymus-dependent immune responses which have undergone immune maturation through somatic hypermutations, they represent the highest quality of the collective maternal immunological experience. Maternal antibodies not only confer passive immunity as long as the newborn's immune system has not fully developed, but also exert an active stimulation as indicated by their regulatory in¯uence on isotype expression, long-term idiotypic alterations, determination of the adult B and T cell repertoire, induction of antigen reactive IgM as well as an af®nity enhancement of a proportion of early primary antibodies. The fact that several of these features can only be induced during limited sensitive periods shortly after birth is reminiscent of the behavioural imprinting as de®ned by Konrad Lorenz. We therefore propose that during early ontogeny there is an immunological imprinting phase with characteristics analogous to behavioural imprinting: (i) the internal imprinting effect is induced by external signals, (ii) in contrast to normal learning, immunological imprinting is also only possible during certain development phases and (iii) it is characterised by an (almost) irreversible result. Hence, if particular immunological experiences are only possible during such sensitive phases, maternal immunoglobulins and consequently the mother's immunological experience is of prime importance for the start of the ontogenetic development of the immune system. On the whole, IgG antibodies are the products of thymusdependent immune responses and as such they mirror the successful interaction of the immune system with the world of external antigens. This process is characterized by an immune maturation which is brought about by somatic hypermutation in the immunoglobulin variable regions and in this way improves the quality of these humoral effector molecules. In mammals, IgG antibodies are transferred from the mother to the offspring either before birth via the placenta and/or after birth with the colostrum and the milk [1], and even in birds [2,3] and ®shes [4] antibodies are transferred to the next generation with the egg yolk. In mammals as well as in birds, there is overwhelming support for the view that these maternal antibodies provide passive protection to the newborns as long as their own immune system has not fully developed. Hence, maternal immunization can be utilized to increase the neonatal antibody titers which protect the offspring against environmental pathogens such as bacterial infections [19]. Moreover, even tumor immunity can be transferred from immunized female mice to the offspring [20±22]. Collectively, these observations provide the basis for a maternal vaccination which is already widely practiced in veterinary medicine [23,24], and also in humans, mothers may...

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“…In the fishery test, the serum physiological and biochemical indexes of fish can reflect the permeability of tissue cells, metabolism and immune function to some extent (Caruso et al, 2005). Erythrocytes are immune and participate in the immune regulation of the body and contain a variety of immune‐related substances (Muscoplat et al, 1977). Leucocytes play an important role in phagocytosis of foreign bodies, antibody production, resistance to pathogenic invasion and immunity (Muscoplat et al, 1977).…”

Section: Discussionmentioning

confidence: 99%

Effects ofBacillus methylotrophicusWM‐1 on water quality dynamics and cultural fish in grass carp culture system

Jiang

Zhang

Luo

et al. 2021

Aquaculture Research

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Microbial agents have been widely used in the Chinese aquaculture industry due to their advantages of enhancing the immunity of aquatic animal, improving disease resistance and improving the aquaculture environment. In previous studies, we found a highly antagonistic Aeromonas hydrophila strain, Bacillus methylotrophicus WM‐1, isolated from grass carp (Ctenopharyngodon idella) culture systems. The purpose of this study was to investigate the impact of WM‐1 on cultured water and fish. Strain WM‐1 was mixed into the feed and fed to the grass carp for 30 days, set control group (CG, 0 CFU/g feed), low concentration group (LG, 103 CFU/g feed), medium concentration group (MG, 105 CFU/g feed) and high concentration group (HG, 107 CFU/g feed). Water quality and physiological indicators of grass carp were tested. Compared with CG, the concentrations of total phosphorus (TP) and soluble reactive phosphorus (SRP) were significantly increased in the MG in the early stage (before day 18, p < 0.05), whereas decreased in the long stage. After the 12th day, treatment groups showed a significant decrease in chemical oxygen demand (COD) (p < 0.05). Total nitrogen (TN), ammonia nitrogen (NH4+‐N), nitrite (NO2‐‐N) and nitrate (NO3‐‐N) had no significant difference (p > 0.05). In grass carp serum, GPT activity in MG and HG was significantly reduced, SOD activity was significantly increased, and POD in MG was significantly higher than LG and HG (p < 0.05). In the liver, the GPT activity of the LG was significantly increased (p < 0.05). Other indicators (the specific growth rate and condition factor of grass carp, serum GOT, AKP and POD activity, total liver protein content, liver SOD, POD, AKP and GPT activity, haemocyte counts) have no significant difference between CG and treatment groups (p > 0.05). The results show that WM‐1 is safe for water quality and culture objects, and has the effects of improving water quality and the immunity of grass carp. The corrent results combined with WM‐1 effectively inhibit A. hydrophila shown that WM‐1 can be applied to aquaculture production as a probiotics.

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Regulation of the Immune Response in Neonatal Piglets by Maternal Antibody

Cited by 16 publications

References 12 publications

The Mammary Gland in Mucosal and Regional Immunity

The Mammary Gland in Mucosal and Regional Immunity

Is There a Maternally Induced Immunological Imprinting Phase à la Konrad Lorenz?

Effects ofBacillus methylotrophicusWM‐1 on water quality dynamics and cultural fish in grass carp culture system

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