2017
DOI: 10.1186/s13223-017-0194-9
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Abstract: BackgroundInterleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is expressed by a number of cell types, including epithelial cells, eosinophils, and activated monocytes and macrophages. To date, however, the regulation of Th2 responses by distinct cell types and tissues expressing IL-31RA has not been well studied.MethodsIn this study, Cry j 2, one of the major allerg… Show more

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Cited by 15 publications
(14 citation statements)
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“…12 The role of the IL-31 signaling pathway in immune regulation remains to be fully elucidated and might be tissue specific. [23][24][25][26] IL-31 also dysregulates the physical and functional properties of the skin barrier, whereas low levels stimulate expression of antimicrobial peptides. 14 Therefore blocking IL-31-mediated signaling can attenuate multiple pathogenic mechanisms in patients with AD, although complete inhibition might be undesirable.…”
Section: Discussionmentioning
confidence: 99%
“…12 The role of the IL-31 signaling pathway in immune regulation remains to be fully elucidated and might be tissue specific. [23][24][25][26] IL-31 also dysregulates the physical and functional properties of the skin barrier, whereas low levels stimulate expression of antimicrobial peptides. 14 Therefore blocking IL-31-mediated signaling can attenuate multiple pathogenic mechanisms in patients with AD, although complete inhibition might be undesirable.…”
Section: Discussionmentioning
confidence: 99%
“…In the Il31ra ‐deficient mice, T H 2‐dependent pulmonary granulomatous reaction induced by Schistosoma mansoni egg injection is significantly augmented in lung, suggesting an inhibitory role of IL‐31/IL‐31R in T H 2 immune response . Intraperitoneal injection of Cryj2 pollen antigen in Il31ra ‐deficient mice also shows a stronger T H 2 response compared to wild‐type mice . In contrast, intranasal application of Cryj2 significantly inhibits the T H 2 response in the Il31ra ‐deficient mice .…”
Section: Structure and Expression Of The Il‐31/il‐31r Systemmentioning
confidence: 92%
“…42 IL-31RA-deficient mice showed a lower T H 2 immune response after nasal allergen administration but a stronger response after intraperitoneal administration. 43 Variation of immune responses in different tissues of IL-31RA-deficient mice might be related to distribution of different IL-31RA isotypes or varied compensatory activity of OSMRb in different tissues.…”
Section: Animal Models Of Il-31 and Pruritusmentioning
confidence: 99%