volume 25, issue 2, P263-277 2011
DOI: 10.3233/jad-2011-102094
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Dang Thanh Nam, Madeleine Arseneault, Charles Ramassamy

Abstract: Lipid peroxidation leads to the formation of a number of by-products including acrolein. In brain from patients with Alzheimer's disease (AD), acrolein was found to be elevated in vulnerable regions. Astrocytes contribute to a variety of neuronal functions but the toxicity of acrolein in astroglial cells remains unknown. Using the rat primary astroglial cells, our results show that acrolein is toxic from 15 μM. Acrolein induced a biphasic effect on glutathione (GSH) levels with a depletion after 30 min of trea…

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