Regulation of progenitor cell survival by a novel chromatin remodeling factor during neural tube development
Noriaki Sasai,
Shogo Tada,
Jumi Ohshiro
et al.
Abstract:During development, progenitor cell survival is essential for proper tissue functions, but the underlying mechanisms are not fully understood. Here we show that ERCC6L2, a member of the Snf2 family of helicase‐like proteins, plays an essential role in the survival of developing chick neural cells. ERCC6L2 expression is induced by the Sonic Hedgehog (Shh) signaling molecule by a mechanism similar to that of the known Shh target genes Ptch1 and Gli1. ERCC6L2 blocks programmed cell death induced by Shh inhibition… Show more
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