Journal of Cell Biology volume 216, issue 11, P3453-3462 2017 DOI: 10.1083/jcb.201705168 View full text
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Chih-Chia Chang, Tzu-Lun Huang, Yuta Shimamoto, Su-Yi Tsai, Kuo-Chiang Hsia

Abstract: NuMA has been suggested to function as a Ran-regulated spindle assembly factor that modulates spindle pole assembly. Chang et al. provide structural and biochemical evidence showing that NuMA contains an Importin-β–regulated microtubule-binding region, which allows Ran to regulate the NuMA functions required for the assembly of higher-order microtubule structures.