Journal of Cell Biology volume 216, issue 6, P1689-1703 2017 DOI: 10.1083/jcb.201607045 View full text
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Cécile Leduc, Sandrine Etienne-Manneville

Abstract: Intermediate filaments (IFs) participate in directed cell migration, but how the IF network becomes polarized in motile cells is unclear. Leduc and Etienne-Manneville show that the turnover of IF mainly relies on actin-driven retrograde flow and microtubule-driven anterograde and retrograde transport. During cell migration, Cdc42-mediated polarity signaling inhibits dynein-dependent transport to promote the polarization of the IF network.